公开(公告)号：US20140039375A1

公开(公告)日：2014-02-06

申请号：US13982642

申请日：2012-02-01

Applicant: Jorge H. Jimenez ,  Ajit P. Yoganathan ,  Seth West ,  Vinod Thourani

Inventor： Jorge H. Jimenez ,  Ajit P. Yoganathan ,  Seth West ,  Vinod Thourani

IPC: A61M27/00 ,  A61B17/02 ,  A61F2/06

CPC classification number: A61B17/3423 ,  A61B17/00234 ,  A61B17/0218 ,  A61B2017/00252 ,  A61B2017/3425 ,  A61F2/064 ,  A61M1/1008 ,  A61M1/3659 ,  A61M27/002

Abstract: Various embodiments of the present invention provide a conduit system including an outer lumen (810), an inner lumen (805), and an attaching device (820). In other embodiments, a multiple access port device adapted for communication with at least one of an outer lumen, an inner lumen, or an attaching device of a conduit system is provided. In yet other embodiments, a system including an inner lumen that is collapsible is provided. Means for closing a conduit system are also provided, including a plug for insertion through an attaching device and a variable radius coiled member associated with an attaching device.

Abstract translation: 本发明的各种实施例提供一种包括外腔（810），内腔（805）和附接装置（820）的导管系统。 在其他实施例中，提供了适于与管道系统的外腔，内腔或附接装置中的至少一个通信的多通道端口装置。 在其他实施例中，提供了包括可折叠的内腔的系统。 还提供了用于封闭导管系统的装置，包括用于插入通过附接装置的插头和与附接装置相关联的可变半径盘绕构件。

公开(公告)号：US20080021368A1

公开(公告)日：2008-01-24

申请号：US10593855

申请日：2005-03-23

Applicant: Lakshmi Prasad Dasi ,  Kerem Pekkan ,  Diane De Julien De Zelicourt ,  Ajit P. Yoganathan ,  Dennis Dam Soerensen

Inventor： Lakshmi Prasad Dasi ,  Kerem Pekkan ,  Diane De Julien De Zelicourt ,  Ajit P. Yoganathan ,  Dennis Dam Soerensen

IPC: A61M5/00

CPC classification number: A61F2/06 ,  A61F2002/068 ,  A61F2230/0054 ,  A61F2230/0056 ,  A61F2230/0058 ,  Y10T137/87249

Abstract: A device for use in the total cavopulmonary connection (TCPC) in order to optimize its hemodynamics. Although the current procedure of choice for single ventricle heart repairs, the TCPC has reduced the post-operative mortality to the level of simpler types of congenital heart disease repairs, Fontan patients are still subjected to serious long-term complications. The TCPC procedure, which restores the vital separation between oxygenated and deoxygenated blood, also leads to an increased workload for the remaining single ventricle, as it is now responsible for pumping the blood through both the systemic and pulmonary circulation. The present device reduces this workload by altering the surgically created design of the TCPC. Improved fluid mechanics and reduced energy dissipation at the connection site translates into less work for the single ventricle and improved transport of deoxygenated blood to the lungs, which may in turn contribute to improved post-operative results and quality of life.

Abstract translation: 用于全肺静脉连接（TCPC）的装置，以优化其血流动力学。 虽然目前的单心室心脏修复方案是选择，但TCPC已经将术后死亡率降低到更简单类型的先天性心脏病修复水平，Fontan患者仍然遭受严重的长期并发症。 恢复氧合和脱氧血液之间重要分离的TCPC程序也导致剩余的单个心室的工作量增加，因为它现在负责通过全身和肺循环泵送血液。 本设备通过更改手术创建的TCPC设计来减少此工作负载。 改善的流体力学和减少的连接部位的能量消耗转化为较少的单一心室的工作和改善的脱氧血液转运到肺部，这可能反过来有助于改善术后结果和生活质量。

公开(公告)号：US10463341B2

公开(公告)日：2019-11-05

申请号：US13991551

申请日：2011-12-15

Applicant: Qifeng Wei ,  Karl E. Thiele ,  Ajit P. Yoganathan ,  Choon-Hwai Yap

Inventor： Qifeng Wei ,  Karl E. Thiele ,  Ajit P. Yoganathan ,  Choon-Hwai Yap

IPC: A61B8/06 ,  A61B8/14 ,  A61B8/00 ,  A61B8/08

Abstract: An ultrasonic diagnostic imaging system is described which quantifies regurgitant flow through a plurality of pinhole leaks or a slit leak of a mitral valve. A plurality of orifice locations of a leaking valve are identified and Doppler values obtained from a flow velocity field proximal each orifice. The Doppler values of each flow velocity field vectorially relating to the orifice location are processed to produce a measure of flow through the orifice. The flow measurements for a plurality of such orifices are summed to produce a quantified measure of regurgitant flow through a plurality of pinhole leaks or along a slit leak.

公开(公告)号：US09320875B2

公开(公告)日：2016-04-26

申请号：US13982642

申请日：2012-02-01

Applicant: Jorge Jimenez ,  Ajit P. Yoganathan ,  Seth West ,  Vinod Thourani

Inventor： Jorge Jimenez ,  Ajit P. Yoganathan ,  Seth West ,  Vinod Thourani

IPC: A61M5/00 ,  A61M27/00 ,  A61F2/06 ,  A61B17/00 ,  A61B17/34 ,  A61B17/02

CPC classification number: A61B17/3423 ,  A61B17/00234 ,  A61B17/0218 ,  A61B2017/00252 ,  A61B2017/3425 ,  A61F2/064 ,  A61M1/1008 ,  A61M1/3659 ,  A61M27/002

Abstract: Various embodiments of the present invention provide a conduit system including an outer lumen (810), an inner lumen (805), and an attaching device (820). In other embodiments, a multiple access port device adapted for communication with at least one of an outer lumen, an inner lumen, or an attaching device of a conduit system is provided. In yet other embodiments, a system including an inner lumen that is collapsible is provided. Means for closing a conduit system are also provided, including a plug for insertion through an attaching device and a variable radius coiled member associated with an attaching device.

Abstract translation: 本发明的各种实施例提供一种包括外腔（810），内腔（805）和附接装置（820）的管道系统。 在其他实施例中，提供了适于与管道系统的外腔，内腔或附接装置中的至少一个通信的多通道端口装置。 在其他实施例中，提供了包括可折叠的内腔的系统。 还提供了用于封闭导管系统的装置，包括用于插入通过附接装置的插头和与附接装置相关联的可变半径盘绕构件。

公开(公告)号：US20090157174A1

公开(公告)日：2009-06-18

申请号：US12097173

申请日：2006-12-15

Applicant: Ajit P. Yoganathan ,  Jorge Hernan Jimenez

Inventor： Ajit P. Yoganathan ,  Jorge Hernan Jimenez

IPC: A61F2/24 ,  A61F2/04

CPC classification number: A61F2/2412 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2002/8483 ,  A61F2002/9528 ,  A61F2250/0059 ,  A61F2250/006

Abstract: The present invention describes a cardiac prosthetic system (400) comprising: an anchoring conduit (200) having a harbour (415), the harbour including a first releasably engaging component (515); a temporary valve (305) and a heart valve prosthesis (420) having a second releasably engaging component (445) enabled to be securely coupled and uncoupled from the first releasably engaging component (515) of the harbour (415).

Abstract translation: 本发明描述了一种心脏假体系统（400），包括：具有港口（415）的锚固管道（200），所述港口包括第一可释放地接合的部件（515）; 临时阀（305）和具有第二可释放接合部件（445）的心脏瓣膜假体（420）能够牢固地联接并离开港口（415）的第一可释放接合部件（515）。

公开(公告)号：US09050189B2

公开(公告)日：2015-06-09

申请号：US13132845

申请日：2009-12-04

Applicant: Sai Muralidhar Padala ,  Ajit P. Yoganathan

Inventor： Sai Muralidhar Padala ,  Ajit P. Yoganathan

IPC: A61F2/24 ,  A61B17/115 ,  A61B17/02 ,  A61B17/00 ,  A61B17/064

CPC classification number: A61F2/2445 ,  A61B17/0218 ,  A61B17/1155 ,  A61B2017/00398 ,  A61B2017/00402 ,  A61B2017/0647 ,  A61F2/2442 ,  A61F2/2466

Abstract: An apparatus (100) for and a method of delivering and implanting a surgical device on an anatomic structure is through minimally invasive procedures. The method is facilitated by an apparatus including a unitary tube (106) operatively connected to a deployment head (118) controlled by an apparatus controller. The deployment head is configured to deploy suture hooks or similar clips that connect an annuloplasty implant to heart tissue and secondary surgical devices to the annuloplasty implant. The apparatus is further configured to facilitate orientation adjustment or collapsing of the deployment head and surgical devices attached thereto in order to facilitate their passing through an incision smaller than generally required. After the deployment head passes through the incision its orientation is readjusted so that it may be positioned and the annuloplasty implant automatically sutured to a heart valve annulus by the apparatus suturing sub-assembly using the suture hooks.

Abstract translation: 用于在解剖结构上递送和植入外科手术装置的装置（100）和方法是通过微创程序。 该方法由包括可操作地连接到由装置控制器控制的展开头（118）的整体管（106）的装置而促进。 部署头被配置成展开缝合钩或类似的夹子，将瓣膜成形植入物连接到心脏组织和辅助外科手术装置到瓣膜成形术植入物。 该装置还被配置为便于展开头和附接到其上的手术装置的取向调节或塌缩，以便于它们通过小于通常所需的切口。 在展开头部通过切口之后，重新调整其方向，使得其可以被定位，并且通过使用缝合钩的装置缝合子组件将瓣环成形术植入物自动缝合到心脏瓣膜环。

公开(公告)号：US20130261458A1

公开(公告)日：2013-10-03

申请号：US13991551

申请日：2011-12-15

Applicant: Qifeng Wei ,  Karl E. Thiele ,  Ajit P. Yoganathan ,  Choon-Hwai Yap

Inventor： Qifeng Wei ,  Karl E. Thiele ,  Ajit P. Yoganathan ,  Choon-Hwai Yap

IPC: A61B8/06 ,  A61B8/00 ,  A61B8/14 ,  A61B8/08

CPC classification number: A61B8/06 ,  A61B8/145 ,  A61B8/4444 ,  A61B8/4488 ,  A61B8/463 ,  A61B8/483 ,  A61B8/488 ,  A61B8/5207 ,  A61B8/5223

Abstract: An ultrasonic diagnostic imaging system is described which quantifies regurgitant flow through a plurality of pinhole leaks or a slit leak of a mitral valve. A plurality of orifice locations of a leaking valve are identified and Doppler values obtained from a flow velocity field proximal each orifice. The Doppler values of each flow velocity field vectorially relating to the orifice location are processed to produce a measure of flow through the orifice. The flow measurements for a plurality of such orifices are summed to produce a quantified measure of regurgitant flow through a plurality of pinhole leaks or along a slit leak.

Abstract translation: 描述了超声波诊断成像系统，其定量通过多个针孔泄漏或二尖瓣的狭缝泄漏的反流量。 识别泄漏阀的多个孔位置，并从每个孔附近的流速场获得多普勒值。 对与孔口位置进行矢量相关的每个流速场的多普勒值进行处理，以产生通过孔口的流量的量度。 将多个这样的孔的流量测量相加以产生通过多个针孔泄漏或沿着狭缝泄漏的回流量的量化测量。

公开(公告)号：US20130030523A1

公开(公告)日：2013-01-31

申请号：US12937191

申请日：2009-04-07

Applicant: Sai Muralidhar Padala ,  Ajit P. Yoganathan ,  Vinod H. Thourani ,  Jorge H. Jimenez

Inventor： Sai Muralidhar Padala ,  Ajit P. Yoganathan ,  Vinod H. Thourani ,  Jorge H. Jimenez

IPC: A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2230/0023 ,  A61F2230/0063 ,  A61F2230/0095 ,  A61F2250/0004

Abstract: An annuloplasty ring, configured for implantation in the annulus of a heart valve, comprising multiple segments each of which are geometrically shaped from a three dimensional perspective to conform to the anatomic shape of the valve annulus. In one embodiment, the annuloplasty ring is configured to facilitate a reduction of tension on heart valve tissue and eliminate a substantial portion of potential pressure or force that may be applied to the atrioventricular node by the annuloplasty ring when implanted. In another embodiment, at the annuloplasty ring is configured to include an assembly that facilitates selective adjustment of a segment's respective length and/or shape. The adjustment of the length of one of the ring segment's results in an adjustment of at least one angle between at least one set of other ring segments, thereby causing an adjustment to the geometric characteristics of the ring.

Abstract translation: 瓣膜成形术环，构造成用于植入心脏瓣膜的环中，包括多个部分，每个部分从三维透视几何形状形成，以符合瓣膜环的解剖形状。 在一个实施例中，瓣膜成形术环被配置为有助于降低心脏瓣膜组织上的张力，并且消除植入时瓣膜成形术环可能施加到房室结的可能的压力或力的大部分。 在另一个实施例中，在瓣环成形术环被配置为包括便于对片段相应长度和/或形状进行选择性调整的组件。 调节环段中的一个的长度导致至少一组其它环段之间的至少一个角度的调整，从而调整环的几何特性。

公开(公告)号：US20110002532A1

公开(公告)日：2011-01-06

申请号：US12878366

申请日：2010-09-09

Applicant: David Harold Frakes ,  Joseph Wilson Monaco ,  Mark J.T. Smith ,  Ajit P. Yoganathan

Inventor： David Harold Frakes ,  Joseph Wilson Monaco ,  Mark J.T. Smith ,  Ajit P. Yoganathan

IPC: G06K9/00

CPC classification number: H04N19/51 ,  G06K9/3216 ,  G06T3/4007 ,  G06T7/11 ,  G06T7/20 ,  G06T2207/10088 ,  G06T2207/30004

Abstract: Approaches to three-dimensional (3D) data reconstruction are presented. The 3D data comprises 2D images. In some embodiments, the 2D images are directionally interpolated to generate directionally-interpolated 3D data. The directionally-interpolated 3D data are then segmented to generate segmented directionally-interpolated 3D data. The segmented directionally-interpolated 3D data is then meshed. In other embodiments, a 3D data set, which includes 2D flow images, is accessed. The accessed 2D flow images are then directionally interpolated to generate 2D intermediate flow images.

Abstract translation: 提出了三维（3D）数据重建的方法。 3D数据包括2D图像。 在一些实施例中，2D图像被定向内插以产生定向内插的3D数据。 然后将定向插值的3D数据分段以产生分段的定向内插3D数据。 然后将分段的定向插值的3D数据进行网格划分。 在其他实施例中，访问包括2D流图像的3D数据集。 然后将访问的2D流图像定向插值以产生2D中间流图像。

公开(公告)号：US09125742B2

公开(公告)日：2015-09-08

申请号：US12096948

申请日：2006-12-15

Applicant: Ajit P. Yoganathan ,  Jorge Hernan Jimenez

Inventor： Ajit P. Yoganathan ,  Jorge Hernan Jimenez

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2457 ,  A61F2250/0004

Abstract: Papillary muscle position control devices (900) systems and methods are provided. According to an exemplary embodiment, a papillary muscle position control device generally comprises a first anchor (905), a second anchor (920), and a support structure (915). The first anchor can be configured to fixedly connect to an in situ valve of a heart ventricle. The second anchor can be configured to fixedly connect to a muscle wall of the valve. The support structure can be configured to have an adjustable length and be coupled to the first anchor and second anchor such that adjusting the length of the support structure varies a distance between the first anchor and the second anchor. Other embodiments are also claimed and described.

Abstract translation: 提供乳头肌位置控制装置（900）的系统和方法。 根据示例性实施例，乳头肌位置控制装置通常包括第一锚（905），第二锚（920）和支撑结构（915）。 第一锚固件可以被配置成固定地连接到心室的原位瓣膜。 第二锚固件可以被配置成固定地连接到阀的肌肉壁。 支撑结构可以被配置为具有可调节的长度并且耦合到第一锚固件和第二锚固件，使得调整支撑结构的长度改变第一锚固件和第二锚固件之间的距离。 还要求保护和描述其它实施例。