公开(公告)号：US20060194871A1

公开(公告)日：2006-08-31

申请号：US10552232

申请日：2004-04-06

Applicant: Kevin Barvian ,  Andrew Carpenter ,  Joel Cooper ,  Paul Feldman ,  Dulce Garrido ,  Yu Guo ,  Anthony Handlon ,  Donald Hertzog ,  Clifton Hyman ,  Andrew Peat ,  Gregory Peckham ,  Jason Speake ,  William Swain ,  Francis Tavares ,  Huiqiang Zhou

Inventor： Kevin Barvian ,  Andrew Carpenter ,  Joel Cooper ,  Paul Feldman ,  Dulce Garrido ,  Yu Guo ,  Anthony Handlon ,  Donald Hertzog ,  Clifton Hyman ,  Andrew Peat ,  Gregory Peckham ,  Jason Speake ,  William Swain ,  Francis Tavares ,  Huiqiang Zhou

IPC: C07D311/80 ,  A61K31/353

CPC classification number: C07D495/04 ,  C07D311/80

Abstract: This invention relates to novel heterocycles which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), also referred to as 11 CBy, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in medicines. Compounds of the invention have the formula:

Abstract translation: 本发明涉及在黑色素浓缩激素受体1（MCHR1），也称为11Cyy的拮抗剂，含有它们的药物组合物，其制备方法及其在药物中的应用的新型杂环。 本发明的化合物具有下式：

公开(公告)号：US20070078125A1

公开(公告)日：2007-04-05

申请号：US10576765

申请日：2004-10-21

Applicant: Kevin Barvian ,  Anthony Handlon ,  Donald Hertzog ,  Clifton Hyman

Inventor： Kevin Barvian ,  Anthony Handlon ,  Donald Hertzog ,  Clifton Hyman

IPC: A61K31/519 ,  A61K31/55 ,  C07D498/02

CPC classification number: C07D495/04

Abstract: This invention relates to novel arylamines which are antagonists of the melanin-concentrating hormone receptor 1 (MCH R1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in medicines for the treatment of obesity, diabetes, depression, and/or anxiety. Compounds of the invention have the formula:

Abstract translation: 本发明涉及作为黑色素浓缩激素受体1（MCH R1）的拮抗剂的新型芳基胺，含有它们的药物组合物，其制备方法及其在药物中的用途，用于治疗肥胖症，糖尿病，抑郁症， 和/或焦虑。 本发明的化合物具有下式：

公开(公告)号：US20050059662A1

公开(公告)日：2005-03-17

申请号：US10850967

申请日：2004-05-21

Applicant: Rustum Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Christopher Conlee ,  Brian Thompson ,  Judith Kuntz ,  David Musso ,  Kevin Barvian ,  Stephen Thomson ,  William Swain ,  Kien Du ,  Brian Chauder ,  Jason Speake ,  Michael Bishop

Inventor： Rustum Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Christopher Conlee ,  Brian Thompson ,  Judith Kuntz ,  David Musso ,  Kevin Barvian ,  Stephen Thomson ,  William Swain ,  Kien Du ,  Brian Chauder ,  Jason Speake ,  Michael Bishop

IPC: A61K31/517 ,  A61K31/519 ,  A61K31/525 ,  A61K31/53 ,  A61P3/04 ,  A61P3/10 ,  C07D217/24 ,  C07D239/91 ,  C07D239/95 ,  C07D239/96 ,  C07D253/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D475/02 ,  C07D487/02 ,  C07D487/04

CPC classification number: C07D217/24 ,  C07D239/91 ,  C07D239/95 ,  C07D239/96 ,  C07D253/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.

Abstract translation: 提供了能够作为MC4-R激动剂的各种小分子，含胍分子。 当给予受试者时，这些化合物可用于治疗MC4-R介导的疾病。 化合物具有结构IA，IB和IC，其中变量的值在本文中定义。

公开(公告)号：US08658641B2

公开(公告)日：2014-02-25

申请号：US13124889

申请日：2009-10-13

Applicant: Kevin Barvian ,  Gregory Steven Basarab ,  Madhusudhan Reddy Gowravaram ,  Sheila Irene Hauck ,  Fei Zhou

Inventor： Kevin Barvian ,  Gregory Steven Basarab ,  Madhusudhan Reddy Gowravaram ,  Sheila Irene Hauck ,  Fei Zhou

IPC: A61K31/5383 ,  C07D413/14

CPC classification number: C07D498/22

Abstract: The present invention relates to compounds of Formula (I); to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation.

Abstract translation: 本发明涉及式（I）的化合物; 其药学上可接受的盐，使用它们来治疗细菌感染的方法及其制备方法。

公开(公告)号：US20110245224A1

公开(公告)日：2011-10-06

申请号：US13124889

申请日：2009-10-13

Applicant: Kevin Barvian ,  Gregory Steven Basarab ,  Madhusudhan Reddy Gowravaram ,  Sheila Irene Hauck ,  Fei Zhou

Inventor： Kevin Barvian ,  Gregory Steven Basarab ,  Madhusudhan Reddy Gowravaram ,  Sheila Irene Hauck ,  Fei Zhou

IPC: A61K31/55 ,  C07D498/22 ,  A61K31/5386 ,  A61K31/527 ,  A61K31/541 ,  A61P31/04

CPC classification number: C07D498/22

Abstract: The present invention relates to compounds of Formula (I); to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation.

Abstract translation: 本发明涉及式（I）的化合物; 其药学上可接受的盐，使用它们治疗细菌感染的方法及其制备方法。