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    Methods for the treatment and prevention of inflammatory diseases
    7.
    发明授权
    Methods for the treatment and prevention of inflammatory diseases 有权
    治疗和预防炎性疾病的方法

    公开(公告)号：US08324237B2

    公开(公告)日：2012-12-04

    申请号：US11437988

    申请日：2006-05-19

    申请人： Charles D. Smith ,  Kevin J. French ,  Lynn W. Maines

    发明人： Charles D. Smith ,  Kevin J. French ,  Lynn W. Maines

    IPC分类号： A61K31/44 ,  A61K31/425

    CPC分类号： A61K31/685

    摘要： The invention includes processes mainly for the treatment of a inflammatory diseases, such as inflammatory bowel disease, arthritis, atherosclerosis, asthma, allergy, inflammatory kidney disease, circulatory shock, multiple sclerosis, chronic obstructive pulmonary disease, skin inflammation, periodontal disease, psoriasis and T cell-mediated diseases of immunity, including allergic encephalomyelitis, allergic neuritis, transplant allograft rejection, graft versus host disease, myocarditis, thyroiditis, nephritis, systemic lupus erthematosus, and insulin-dependent diabetes mellitus. The processes involve treating a patient with a pharmaceutical composition containing an active ingredient that inhibits the activity of sphingosine kinase.

    摘要翻译： 本发明包括主要用于治疗诸如炎性肠病，关节炎，动脉粥样硬化，哮喘，变态反应，炎症性肾病，循环性休克，多发性硬化，慢性阻塞性肺疾病，皮肤炎症，牙周病，牛皮癣和炎症性疾病 T细胞介导的免疫疾病，包括过敏性脑脊髓炎，过敏性神经炎，移植异种移植排斥反应，移植物抗宿主病，心肌炎，甲状腺炎，肾炎，系统性红斑狼疮和胰岛素依赖性糖尿病。 该方法包括用含有抑制鞘氨醇激酶活性的活性成分的药物组合物治疗患者。