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公开(公告)号：US20090305394A1
公开(公告)日：2009-12-10
申请号：US12160965
申请日：2007-01-18
申请人： Sang Yup Lee , So Young Yoo , Eung Kweon Kim , Ki-Chang Keum , Won-Min Yoo , Nae-Choon Yoo
发明人： Sang Yup Lee , So Young Yoo , Eung Kweon Kim , Ki-Chang Keum , Won-Min Yoo , Nae-Choon Yoo
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to oligonucleotides for diagnosis of corneal dystrophy. More particularly, the present invention relates to oligonucleotides for detecting mutation of BIGH3 gene for diagnosis or corneal dystrophy including Avellino corneal dystrophy, which must be precisely diagnosed before vision correction surgery, and a DNA chip for diagnosis of corneal dystrophy, which has the oligonucleotides fixed thereon. According to the present invention, conventional microscopic diagnosis of corneal dystrophy can be replaced with a precise genetic method, which prevents a patient with corneal dystrophy from losing eyesight by eyesight correction surgery after erroneous diagnosis.
摘要翻译： 本发明涉及用于诊断角膜营养不良的寡核苷酸。 更具体地，本发明涉及用于检测用于诊断或角膜营养不良的BIGH3基因的突变的寡核苷酸，其包括在视力矫正手术之前必须精确诊断的Avellino角膜营养不良，以及用于诊断角膜营养不良的DNA芯片，其具有固定的寡核苷酸 上。 根据本发明，可以用精确的遗传方法代替常规的角膜营养不良症的微观诊断，其可以防止角膜营养不良患者在错误诊断后通过视力矫正手术而失去视力。
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2.发明申请G-CSF PROTEIN HAVING A DELETION OF AN AMINO ACID SEQUENCE CORRESPONDING TO EXON 3 FOR USE AS A DIAGNOSTIC CANCER MARKER 审中-公开具有相关性的氨基酸序列的G-CSF蛋白3用作诊断性癌症标记公开(公告)号：US20120322684A1
公开(公告)日：2012-12-20
申请号：US13546972
申请日：2012-07-11
申请人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07K14/535 , C12Q1/68 , C40B30/04 , C07H21/04
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。
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3.发明申请DIAGNOSTIC METHOD FOR CANCER CHARACTERIZED IN THE DETECTION OF THE DELETION OF G-CSF EXON 3 审中-公开检测G-CSF外显子3检测中的癌症诊断方法公开(公告)号：US20100286381A1
公开(公告)日：2010-11-11
申请号：US12830085
申请日：2010-07-02
申请人： Sang Yup LEE , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup LEE , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。
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公开(公告)号：US20090269750A1
公开(公告)日：2009-10-29
申请号：US12161005
申请日：2007-01-18
申请人： Sang Yup Lee , Nae-Choon Yoo , So Young Yoo , Ki-Chang Keum , Won-Min Yoo
发明人： Sang Yup Lee , Nae-Choon Yoo , So Young Yoo , Ki-Chang Keum , Won-Min Yoo
CPC分类号： C07K14/535 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to a diagnostic cancer marker using variation of a granulocyte colony stimulating factor (G-CSF) gene and a method for preparing the same, and more specifically, relates to a method for diagnosing cancer and/or assessing the state of cancer progression using an oligonucleotide having the 3′-terminal end of exon 2 region linked to the 5′-terminal end of exon 4 region of a G-CSF gene as a diagnostic cancer marker. According to the present invention, cancer can be quickly and exactly diagnosed using variation in a G-CSF gene expression.
摘要翻译： 本发明涉及使用粒细胞集落刺激因子（G-CSF）基因变异的诊断性癌症标志物及其制备方法，更具体地涉及诊断癌症和/或评价癌症状态的方法 使用具有与G-CSF基因的外显子4区的5'末端连接的外显子2的3'末端的寡核苷酸作为诊断性癌症标志物进行。 根据本发明，可以使用G-CSF基因表达的变化快速且准确地诊断癌症。
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5.发明授权Multi-spot metal-capped nanostructure array nucleic acid chip for diagnosis of corneal dystrophy and preparation method thereof 有权用于诊断角膜营养不良的多点金属封端纳米结构阵列核酸芯片及其制备方法公开(公告)号：US09145583B2
公开(公告)日：2015-09-29
申请号：US13391167
申请日：2010-08-18
申请人： Sang Yup Lee , So Young Yoo , Do Kyun Kim , Tae Jung Park , Jung Kuk Yun , Gene Lee
发明人： Sang Yup Lee , So Young Yoo , Do Kyun Kim , Tae Jung Park , Jung Kuk Yun , Gene Lee
CPC分类号： C12Q1/6837 , B01J2219/00509 , B01J2219/00608 , B01J2219/00612 , B01J2219/00614 , B01J2219/00621 , B01J2219/00637 , B01J2219/00648 , B01J2219/00722 , B82Y30/00 , C12Q1/6883 , C12Q2600/158
摘要： A multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing corneal dystrophy, and more particularly to a multi-spot metal-capped nanostructure array nucleic acid chip capable of employing LSPR (localized surface plasmon resonance) optical properties, a preparation method thereof, and a multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations, which can diagnose various corneal dystrophies. The metal-capped nanostructure array nucleic acid chip can be combined with analysis devices, including a light source, a detector, a spectrophotometer and a computer, to provide an LSPR optical property-based optical biosensor, and the use of the multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations allows the simultaneous diagnosis of various corneal dystrophies that are genetic ocular diseases.
摘要翻译： 一种用于诊断角膜营养不良的多点金属帽纳米结构阵列核酸芯片，更具体地涉及能够使用LSPR（局部表面等离子共振）光学性质的多点金属封端的纳米结构阵列核酸芯片，其制备方法 ，以及用于诊断BIGH3基因突变的多点金属帽纳米结构阵列核酸芯片，其可以诊断各种角膜营养不良。 金属封端的纳米结构阵列核酸芯片可以与包括光源，检测器，分光光度计和计算机的分析装置组合，以提供基于LSPR光学性质的光学生物传感器，并且使用多点金属 用于诊断BIGH3基因突变的封闭的纳米结构阵列核酸芯片允许同时诊断作为遗传性眼部疾病的各种角膜营养不良。
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6.发明申请MULTI-SPOT METAL-CAPPED NANOSTRUCTURE ARRAY NUCLEIC ACID CHIP FOR DIAGNOSING OF CORNEAL DYSTROPHY AND PREPARATION METHOD THEREOF PRODUCING SAME 有权多点金属填充纳米结构阵列核苷酸芯片，用于诊断角膜晶状体及其制备方法公开(公告)号：US20140243222A1
公开(公告)日：2014-08-28
申请号：US13391167
申请日：2010-08-18
申请人： Sang Yup Lee , So Young Yoo , Do Kyun Kim , Tae Jung Park , Jung Kuk Yun , Gene Lee
发明人： Sang Yup Lee , So Young Yoo , Do Kyun Kim , Tae Jung Park , Jung Kuk Yun , Gene Lee
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01J2219/00509 , B01J2219/00608 , B01J2219/00612 , B01J2219/00614 , B01J2219/00621 , B01J2219/00637 , B01J2219/00648 , B01J2219/00722 , B82Y30/00 , C12Q1/6883 , C12Q2600/158
摘要： A multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing corneal dystrophy, and more particularly to a multi-spot metal-capped nanostructure array nucleic acid chip capable of employing LSPR (localized surface plasmon resonance) optical properties, a preparation method thereof, and a multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations, which can diagnose various corneal dystrophies. The metal-capped nanostructure array nucleic acid chip can be combined with analysis devices, including a light source, a detector, a spectrophotometer and a computer, to provide an LSPR optical property-based optical biosensor, and the use of the multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations allows the simultaneous diagnosis of various corneal dystrophies that are genetic ocular diseases.
摘要翻译： 一种用于诊断角膜营养不良的多点金属帽纳米结构阵列核酸芯片，更具体地涉及能够使用LSPR（局部表面等离子共振）光学性质的多点金属封端的纳米结构阵列核酸芯片，其制备方法 ，以及用于诊断BIGH3基因突变的多点金属帽纳米结构阵列核酸芯片，其可以诊断各种角膜营养不良。 金属封端的纳米结构阵列核酸芯片可以与包括光源，检测器，分光光度计和计算机的分析装置组合，以提供基于LSPR光学性质的光学生物传感器，并且使用多点金属 用于诊断BIGH3基因突变的封闭的纳米结构阵列核酸芯片允许同时诊断作为遗传性眼部疾病的各种角膜营养不良。
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7.发明申请METHOD OF DIAGNOSING CANCER USING G-CSF PROTEIN HAVING A DELETION OF AN AMINO ACID SEQUENCE CORRESPONDING TO EXON 3 AS A DIAGNOSTIC CANCER MARKER 审中-公开使用具有与作为诊断性癌症标记的外显子3相关的氨基酸序列的G-CSF蛋白质诊断癌症的方法公开(公告)号：US20120329078A1
公开(公告)日：2012-12-27
申请号：US13546966
申请日：2012-07-11
申请人： SANG YUP LEE , NAE CHOON YOO , SO YOUNG YOO , HYUN CHEOL CHUNG , KI CHANG KEUM , WON MIN YOO , KI JUN JEONG
发明人： SANG YUP LEE , NAE CHOON YOO , SO YOUNG YOO , HYUN CHEOL CHUNG , KI CHANG KEUM , WON MIN YOO , KI JUN JEONG
IPC分类号： G01N33/574
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。
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8.发明授权公开(公告)号：US08324363B2
公开(公告)日：2012-12-04
申请号：US11058976
申请日：2005-02-16
申请人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07H21/04 , C12Q1/68 , C07K14/535
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。
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公开(公告)号：US20140005365A1
公开(公告)日：2014-01-02
申请号：US13546975
申请日：2012-07-11
申请人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
发明人： Sang Yup Lee , Nae Choon Yoo , So Young Yoo , Hyun Cheol Chung , Ki Chang Keum , Won Min Yoo , Ki Jun Jeong
IPC分类号： C07K16/24
CPC分类号： C07K16/243 , C12Q1/6886 , C12Q2600/156
摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.
摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。
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