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公开(公告)号：US08008050B2
公开(公告)日：2011-08-30
申请号：US11738422
申请日：2007-04-20
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US07829129B2
公开(公告)日：2010-11-09
申请号：US11738416
申请日：2007-04-20
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US20080032355A1
公开(公告)日：2008-02-07
申请号：US11738418
申请日：2007-04-20
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
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4.发明申请Production of high levels of DHA in microalgae using modified amounts of chloride and potassium 有权使用改良量的氯化物和钾在微藻中生产高水平的DHA公开(公告)号：US20050112736A1
公开(公告)日：2005-05-26
申请号：US10957075
申请日：2004-10-01
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
IPC分类号： C12P7/64
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US20160355749A1
公开(公告)日：2016-12-08
申请号：US15106752
申请日：2014-12-18
申请人： Kirk APT , William BARCLAY , Micah BLAZER , Jacob BORDEN , Adam BURJA , Daniel Dong , Armando DURAZO , Jean-Charles DUMENIL , Arthur EDGE , Jon HANSEN , Alexandra HOFLER , David JEFFERS , Chris LYON , Vidya PAI , Joseph William PFEIFER, III , Martin J. SELLERS , Ginger SHANK , Justin STEGE
发明人： Kirk APT , William BARCLAY , Micah BLAZER , Jacob BORDEN , Adam BURJA , Daniel Dong , Armando DURAZO , Jean-Charles DUMENIL , Arthur EDGE , Jon HANSEN , Alexandra HOFLER , David JEFFERS , Chris LYON , Vidya PAI , Joseph William PFEIFER, III , Martin J. SELLERS , Ginger SHANK , Justin STEGE
CPC分类号： C11B1/025 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C11B1/10 , C11B1/12 , C12N1/063 , C12N1/066 , C12N9/2411 , C12N9/2414 , C12N9/2488 , C12P7/6463 , C12Y302/01001 , Y02E50/343
摘要： Methods and systems used to extract lipids suitable in production of biofuels from a fermentation broth may include using heat to pre-treat the fermentation broth in order to more easily extract a product from oleaginous microorganisms in the broth. Additionally or alternatively, a combination of enzymes including amylase, 1-4 mannosidase, and 1-3 mannosidase may be used to break down cell walls of the oleaginous microorganisms. Residual broth water may be recycled and used as imbibition water for washing a process feedstock to extract sugar.
摘要翻译： 用于提取适合于从发酵液生产生物燃料的脂质的方法和系统可包括使用热来预处理发酵液，以便更容易地从肉汤中的含油微生物中提取产物。 另外或替代地，可以使用包括淀粉酶，1-4甘露糖苷酶和1-3甘露糖苷酶的酶的组合来分解含油微生物的细胞壁。 残余肉汤水可以循环使用，并用作洗涤水以洗涤工艺原料以提取糖。
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6.发明申请Low Polysaccharide Microorganisms for Production of Biofuels and Other Renewable Materials 审中-公开用于生产生物燃料和其他可再生材料的低多糖微生物公开(公告)号：US20140137463A1
公开(公告)日：2014-05-22
申请号：US13859229
申请日：2013-04-09
申请人： Kirk Apt , Jacob Borden , Paul W. Behrens , David Dain , Jon Hansen , Joseph W. Pfeifer
发明人： Kirk Apt , Jacob Borden , Paul W. Behrens , David Dain , Jon Hansen , Joseph W. Pfeifer
CPC分类号： C12P7/6409 , C10L1/1802 , C11B1/025 , C11C3/10 , C12N1/16 , C12P7/649 , C12R1/645 , F02B43/00 , Y02E50/13 , Y02E50/343 , Y02T10/32
摘要： High cell density fermentations of wild-type organisms can result in increased viscosity due to the production of exocellular polysaccharides. Mutant microorganisms with a dry morphology, resulting from reduced exocellular polysaccharide formation, were isolated and characterized. The exocellular polysaccharide composition for these modified microorganisms is shown to be different than the polysaccharide composition of the wild type microorganism. In addition to reduced exocellular polysaccharide formation, dry morphology mutants of multiple strains show reduced viscosity, improved oxygen mass transfer, and improved fatty acid fermentation yield on carbon.
摘要翻译： 由于外细胞多糖的生成，野生型生物体的高细胞密度发酵可导致粘度增加。 分离和表征了由减少的外细胞多糖形成导致的具有干燥形态的突变微生物。 这些改性微生物的外细胞多糖组合物显示与野生型微生物的多糖组成不同。 除了减少的外细胞多糖形成，多种菌株的干态形态突变体显示出降低的粘度，改善的氧传质，以及改进的碳的脂肪酸发酵产率。
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7.发明授权Production of DHA in microalgae in medium having modified amounts of potassium 有权在具有改性量的钾的培养基中，在微藻中生产DHA公开(公告)号：US07824892B2
公开(公告)日：2010-11-02
申请号：US11738425
申请日：2007-04-20
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US20080032353A1
公开(公告)日：2008-02-07
申请号：US11738414
申请日：2007-04-20
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US20060100279A1
公开(公告)日：2006-05-11
申请号：US11313524
申请日：2005-12-20
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
IPC分类号： C12P7/64 , A61K31/202
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US20080032359A1
公开(公告)日：2008-02-07
申请号：US11738434
申请日：2007-04-20
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
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