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1.发明申请Modular System for Evaluating Helmet and Suspension Materials for Protection of Neural Cells from Simulated Trauma 有权用于评估头盔和悬架材料的模块化系统，用于保护神经细胞免受模拟创伤公开(公告)号：US20160076967A1
公开(公告)日：2016-03-17
申请号：US14486622
申请日：2014-09-15
Applicant: Thomas O'Shaughnessy , Ryan McCulloch , Amit Bagchi , Kirth Simmonds , Clark Mitchell
Inventor： Thomas O'Shaughnessy , Ryan McCulloch , Amit Bagchi , Kirth Simmonds , Clark Mitchell
CPC classification number: G01M7/08 , G01L5/0052 , G01N3/303
Abstract: A modular system is designed to interface cell cultures to a shock tube (simulated blast) and/or drop tower (simulated blunt impact) for testing of helmet and helmet pad materials for mitigating cell injury. It includes a set of layers including helmet material, optionally helmet pad, simulated skin, simulated skull, and simulated bulk brain tissue.
Abstract translation: 模块化系统设计用于将细胞培养物与用于测试头盔和头盔垫材料的休克管（模拟爆炸）和/或滴塔（模拟钝发冲击）相接触，以减轻细胞损伤。 它包括一组层，包括头盔材料，可选的头盔垫，模拟皮肤，模拟颅骨和模拟的大脑组织。
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2.发明授权公开(公告)号：US09395265B2
公开(公告)日：2016-07-19
申请号：US14576689
申请日：2014-12-19
Applicant: Thomas O'Shaughnessy , Ryan McCulloch , Amit Bagchi , Kirth Simmonds
Inventor： Thomas O'Shaughnessy , Ryan McCulloch , Amit Bagchi , Kirth Simmonds
CPC classification number: G01M7/08 , C12M23/12 , C12M25/14 , C12M41/00 , C12M41/40 , G01L5/0052 , G01L5/14 , G01N33/5058
Abstract: A system for testing a helmet includes a simulated skull comprising a cranial cavity; a brain surrogate disposed inside the cranial cavity; and a cell pack comprising at least one culture well suitable for three-dimensional growth of live neurons therein, the cell pack comprising a retaining plate having at least one opening exposing a portion of a flexible membrane containing the at least one cell culture well, the exposed membrane portion being substantially flush with an exterior surface of the retaining plate, wherein the brain surrogate is configured to closely surround the cell pack inside the simulated skull. Also disclosed is a method of using the system.
Abstract translation: 用于测试头盔的系统包括：颅骨，包括颅腔; 设置在颅腔内的脑替代物; 以及包含至少一种适合于其中的活神经元的三维生长的培养物的细胞包，所述细胞包含有保持板，所述保持板具有至少一个开口，所述至少一个开口暴露包含至少一个细胞培养物的柔性膜的一部分， 暴露的膜部分基本上与保持板的外表面齐平，其中脑替代物构造成紧密围绕模拟颅骨内的细胞包。 还公开了使用该系统的方法。
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Patent Agency Ranking
3.发明申请公开(公告)号：US20160178476A1
公开(公告)日：2016-06-23
申请号：US14576689
申请日：2014-12-19
Applicant: Thomas O'Shaughnessy , Ryan McCulloch , Amit Bagchi , Kirth Simmonds
Inventor： Thomas O'Shaughnessy , Ryan McCulloch , Amit Bagchi , Kirth Simmonds
CPC classification number: G01M7/08 , C12M23/12 , C12M25/14 , C12M41/00 , C12M41/40 , G01L5/0052 , G01L5/14 , G01N33/5058
Abstract: A system for testing a helmet includes a simulated skull comprising a cranial cavity; a brain surrogate disposed inside the cranial cavity; and a cell pack comprising at least one culture well suitable for three-dimensional growth of live neurons therein, the cell pack comprising a retaining plate having at least one opening exposing a portion of a flexible membrane containing the at least one cell culture well, the exposed membrane portion being substantially flush with an exterior surface of the retaining plate, wherein the brain surrogate is configured to closely surround the cell pack inside the simulated skull. Also disclosed is a method of using the system.
Abstract translation: 用于测试头盔的系统包括：颅骨，包括颅腔; 设置在颅腔内的脑替代物; 以及包含至少一种适合于其中的活神经元的三维生长的培养物的细胞包，所述细胞包含有保持板，所述保持板具有至少一个开口，所述至少一个开口暴露包含至少一个细胞培养物的柔性膜的一部分， 暴露的膜部分基本上与保持板的外表面齐平，其中脑替代物构造成紧密围绕模拟颅骨内的细胞包。 还公开了使用该系统的方法。
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公开(公告)号：US20080098500A1
公开(公告)日：2008-05-01
申请号：US11298283
申请日：2005-12-09
Applicant: Peter Matic , Graham Hubler , Kirth Simmonds , James Sprague , Nevin Rupert , John Joseph Frost , Donna Branson , Cheryl Farr , Semra Peksoz , Richard Steven Bruno
Inventor： Peter Matic , Graham Hubler , Kirth Simmonds , James Sprague , Nevin Rupert , John Joseph Frost , Donna Branson , Cheryl Farr , Semra Peksoz , Richard Steven Bruno
IPC: F41H1/02
CPC classification number: F41H1/02
Abstract: Body armor for ballistic protection of a user's extremities preferably comprising right and left arm protection units and/or right and left leg protection units. The units include a ballistic protection material which preferably covers most of the user's upper arm, elbow region, lower arm, shoulder, upper leg, knee region, and lower leg except for ventilation zones preferably located on the inner portion of the upper arm and the inner part of the upper leg. The back of the knee is preferably covered by a protective flap.
Abstract translation: 优选地包括右臂和左臂保护单元和/或右腿和左腿保护单元的用于使用者四肢的弹道保护的防弹装置。 这些单元包括优选地覆盖用户的上臂，肘部区域，下臂，肩部，大腿，膝部区域和小腿的大部分的防弹材料，除了优选位于上臂的内部上的通气区域和 大腿的内部。 膝盖的后部优选地被保护性皮瓣覆盖。
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5.发明授权Modular system for evaluating helmet and suspension materials for protection of neural cells from simulated trauma 有权用于评估头盔和悬架材料的模块化系统，用于保护神经细胞免受模拟创伤公开(公告)号：US09488547B2
公开(公告)日：2016-11-08
申请号：US14486622
申请日：2014-09-15
Applicant: Thomas O'Shaughnessy , Ryan McCulloch , Amit Bagchi , Kirth Simmonds , Clark Mitchell
Inventor： Thomas O'Shaughnessy , Ryan McCulloch , Amit Bagchi , Kirth Simmonds , Clark Mitchell
CPC classification number: G01M7/08 , G01L5/0052 , G01N3/303
Abstract: A modular system is designed to interface cell cultures to a shock tube (simulated blast) and/or drop tower (simulated blunt impact) for testing of helmet and helmet pad materials for mitigating cell injury. It includes a set of layers including helmet material, optionally helmet pad, simulated skin, simulated skull, and simulated bulk brain tissue.
Abstract translation: 模块化系统设计用于将细胞培养物与用于测试头盔和头盔垫材料的休克管（模拟爆炸）和/或滴塔（模拟钝发冲击）相接触，以减轻细胞损伤。 它包括一组层，包括头盔材料，可选的头盔垫，模拟皮肤，模拟颅骨和模拟的大脑组织。
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6.发明申请Cell Pack for the Growth and Manipulation of Three Dimensional Cell Cultures 审中-公开用于三维细胞培养物的生长和操作的细胞包公开(公告)号：US20140273062A1
公开(公告)日：2014-09-18
申请号：US14197724
申请日：2014-03-05
Applicant: Thomas O'Shaughnessy , Paul T. Charles , Kirth Simmonds , Amit Bagchi , Ryan Mcculloch
Inventor： Thomas O'Shaughnessy , Paul T. Charles , Kirth Simmonds , Amit Bagchi , Ryan Mcculloch
IPC: C12M1/12
Abstract: Described herein is a sealed cell pack with a permeable membrane for growth and manipulation of three-dimensional cell cultures. This allows a cell culture to be removed from the laboratory and subjected to real world insults before being returned to culture conditions for continued growth and study. One application is for use in the study of the direct effects of blast waves on neuronal cells and methods for mitigating this response.
Abstract translation: 本文描述的是具有用于生长和操纵三维细胞培养物的可渗透膜的密封电池组。 这样可以将细胞培养物从实验室中除去，并在被返回到培养条件下继续进行真实世界的侮辱以继续生长和研究。 一种应用用于研究爆炸波对神经元细胞的直接作用以及减轻该反应的方法。
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公开(公告)号：US20060191544A1
公开(公告)日：2006-08-31
申请号：US11365952
申请日：2006-02-28
Applicant: Kirth Simmonds , Richard Everett , Peter Matic , Alan Leung
Inventor： Kirth Simmonds , Richard Everett , Peter Matic , Alan Leung
CPC classification number: A61K36/54 , A61K38/014 , A61K2300/00
Abstract: An nstrumented thoracic model for measuring the effects of impacts is provided. The model has simulated skeletal components, simulated tissue, simulated internal organs, and sensors that are optimally placed in the simulated tissue and organs, said simulated organs and said simulated skeletal components. Simulated human tissue is made of a modified ballistic gelatin, comprising ordinance gelatin, chilled water and an antimicrobial agent in a desired volume or weight percentage. The resulting mixture is then poured into a container or mold having the desired tissue shape, and then chilled until the mixture has set. Simulated lung tissue is made of the modified ballistic gelatin, but also incorporates nicrospheres to approximate the density and modality of the lungs. The sensors of the thoracic model are optimally placed using primary component analysis
Abstract translation: 提供了一种用于测量影响影响的仪器胸廓模型。 该模型模拟骨骼组件，模拟组织，模拟内脏和最佳放置在模拟组织和器官中的传感器，所述模拟器官和所述模拟骨骼组件。 模拟的人体组织由改进的弹道明胶制成，包括规定的明胶，冷冻水和抗微生物剂，所需体积或重量百分比。 然后将所得混合物倒入具有所需组织形状的容器或模具中，然后冷却直至混合物固化。 模拟的肺组织由改良的弹道明胶制成，但也包含微球以近似肺的密度和形态。 胸部模型的传感器使用主要成分分析进行了优化
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