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1.发明授权公开(公告)号：US08192924B1
公开(公告)日：2012-06-05
申请号：US13274593
申请日：2011-10-17
申请人： Maurice Barakat , Louis Thibault , Klaus H. Haarmann , Annie Beauséjour , Anthony Alleva , Mario Tremblay , Serghe Lapointe
发明人： Maurice Barakat , Louis Thibault , Klaus H. Haarmann , Annie Beauséjour , Anthony Alleva , Mario Tremblay , Serghe Lapointe
CPC分类号： B65B3/04 , A01N1/0252 , A01N1/0284 , B29C65/8238 , B29C66/1122 , B29C66/242 , B29C66/43 , B29C66/71 , B29D22/003 , B29L2031/7148 , F28D20/02 , F28D2020/0008 , Y02E60/145 , Y10T156/10 , Y10T428/13 , Y10T428/1352 , Y10T428/1393 , Y10T428/231 , Y10T428/234 , Y10T428/239 , B29K2023/06
摘要： A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol, 1.5% myristyl alcohol and 0.5% 1-decanol (having a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design used double-layered transparent polyethylene, with two sealed compartments filled with the solution, separated by a flattened and sealed portion between them. One of the two sealed compartments contacts one side of the blood bag and the other compartment is folded over to contact the other side of the blood bag. The transparent compartments allows an operator to verify at any time whether the solution is in a solid state, and the flexibility of the compartments eases the proper positioning of them around a blood bag.
摘要翻译： 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 将包含在密封的柔性聚合物层中的包含98％1-十二烷醇，1.5％十四烷醇和0.5％1-癸醇（熔点约23℃）的优选共晶溶液的系统用于冷却全血 填充袋。 优选的设计是使用双层透明聚乙烯，其中两个密封隔室填充有溶液，它们之间被平坦且密封的部分隔开。 两个密封隔室中的一个接触血袋的一侧，另一个隔室被折叠以接触血袋的另一侧。 透明隔间允许操作者随时验证溶液是否处于固体状态，并且隔室的柔性使其在血袋周围的适当定位变得容易。
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公开(公告)号：US08802364B2
公开(公告)日：2014-08-12
申请号：US13707637
申请日：2012-12-07
CPC分类号： B65B3/04 , A01N1/0252 , A01N1/0284 , B29C65/8238 , B29C66/1122 , B29C66/242 , B29C66/43 , B29C66/71 , B29D22/003 , B29L2031/7148 , F28D20/02 , F28D2020/0008 , Y02E60/145 , Y10T156/10 , Y10T428/13 , Y10T428/1352 , Y10T428/1393 , Y10T428/231 , Y10T428/234 , Y10T428/239 , B29K2023/06
摘要： A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol 1.5% myristyl alcohol and 0.5% 1-decanol (having a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design uses inner and outer containers, each made of transparent polyethylene sheets, where the inner compartments are filled with the solution and sealed, and then placed into each compartment in an outer container, wherein two compartments in the outer container are separated by a flattened and sealed portion of the polyethylene.
摘要翻译： 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 使用包含98％1-十二烷醇1.5％肉豆蔻醇和0.5％1-癸醇（熔点约23℃）的包含在密封的柔性聚合物层中的共晶溶液的系统来冷却全血 - 填充袋。 优选的设计使用每个由透明聚乙烯片形成的内部和外部容器，其中内部隔室填充有溶液并密封，然后将其放置在外部容器中的每个隔间中，其中外部容器中的两个隔室被 扁平和密封的聚乙烯部分。
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3.发明授权公开(公告)号：US08375730B2
公开(公告)日：2013-02-19
申请号：US13358662
申请日：2012-01-26
CPC分类号： G06Q10/0832 , F25D3/08 , F25D3/14 , F25D2500/04 , G06Q30/012 , G06Q50/28
摘要： Disclosed is a process of selecting of a container and temperature-control system, such that biological products (including blood) requiring maintenance within a specified range of temperatures are so maintained during shipment. The process requires a prediction of the maximum period of shipment, and the predicted ambient temperature ranges and time of exposure thereto for the system during the period of shipment. With that information, a system of container(s) with temperature-control agents including dry ice, ice, frozen gel packs or a phase change material, is selected.
摘要翻译： 公开了一种选择容器和温度控制系统的方法，使得在运输期间维持在特定温度范围内需要维护的生物制品（包括血液）。 该过程需要预测装运期间的最大装运周期，以及预计的环境温度范围和系统暴露于其中的时间。 使用该信息，选择具有包括干冰，冰，冷冻凝胶包或相变材料在内的温度控制剂的容器系统。
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公开(公告)号：US20130255847A1
公开(公告)日：2013-10-03
申请号：US13707637
申请日：2012-12-07
IPC分类号： B29D22/00
CPC分类号： B65B3/04 , A01N1/0252 , A01N1/0284 , B29C65/8238 , B29C66/1122 , B29C66/242 , B29C66/43 , B29C66/71 , B29D22/003 , B29L2031/7148 , F28D20/02 , F28D2020/0008 , Y02E60/145 , Y10T156/10 , Y10T428/13 , Y10T428/1352 , Y10T428/1393 , Y10T428/231 , Y10T428/234 , Y10T428/239 , B29K2023/06
摘要： A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol 1.5% myristyl alcohol and 0.5% 1-decanol (having a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design uses inner and outer containers, each made of transparent polyethylene sheets, where the inner compartments are filled with the solution and sealed, and then placed into each compartment in an outer container, wherein two compartments in the outer container are separated by a flattened and sealed portion of the polyethylene.
摘要翻译： 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 使用包含98％1-十二烷醇1.5％肉豆蔻醇和0.5％1-癸醇（熔点约23℃）的包含在密封的柔性聚合物层中的共晶溶液的系统来冷却全血 - 填充袋。 优选的设计使用每个由透明聚乙烯片形成的内部和外部容器，其中内部隔室填充有溶液并密封，然后将其放置在外部容器中的每个隔间中，其中外部容器中的两个隔室被 扁平和密封的聚乙烯部分。
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公开(公告)号：US08349552B2
公开(公告)日：2013-01-08
申请号：US13431383
申请日：2012-03-27
CPC分类号： B65B3/04 , A01N1/0252 , A01N1/0284 , B29C65/8238 , B29C66/1122 , B29C66/242 , B29C66/43 , B29C66/71 , B29D22/003 , B29L2031/7148 , F28D20/02 , F28D2020/0008 , Y02E60/145 , Y10T156/10 , Y10T428/13 , Y10T428/1352 , Y10T428/1393 , Y10T428/231 , Y10T428/234 , Y10T428/239 , B29K2023/06
摘要： A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol, 1.5% myristyl alcohol and 0.5% 1-decanol (having, a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design uses inner and outer containers, each made of transparent polyethylene sheets, where the inner compartments are filled with the solution and sealed, and then placed into each compartment in an outer container, wherein two compartments in the outer container are separated by a flattened and sealed portion of the polyethylene.
摘要翻译： 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 使用包含98％1-十二烷醇，1.5％十四烷醇和0.5％1-癸醇（具有熔点约23℃）的优选共晶溶液的体系，其包含在密封的柔性聚合物层中，用于冷却整个 充血袋 优选的设计使用每个由透明聚乙烯片形成的内部和外部容器，其中内部隔室填充有溶液并密封，然后将其放置在外部容器中的每个隔间中，其中外部容器中的两个隔室被 扁平和密封的聚乙烯部分。
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公开(公告)号：US20120266564A1
公开(公告)日：2012-10-25
申请号：US13431383
申请日：2012-03-27
IPC分类号： B65B3/04
CPC分类号： B65B3/04 , A01N1/0252 , A01N1/0284 , B29C65/8238 , B29C66/1122 , B29C66/242 , B29C66/43 , B29C66/71 , B29D22/003 , B29L2031/7148 , F28D20/02 , F28D2020/0008 , Y02E60/145 , Y10T156/10 , Y10T428/13 , Y10T428/1352 , Y10T428/1393 , Y10T428/231 , Y10T428/234 , Y10T428/239 , B29K2023/06
摘要： A new blood unit cooling system was designed to cool blood rapidly to about 22° C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% -dodecanol, 1.5% myristyl alcohol and 0.5% 1-decanol (having, a melting point of about 23° C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design uses inner and outer containers, each made of transparent polyethylene sheets, where the inner compartments are filled with the solution and sealed, and then placed into each compartment in an outer container, wherein two compartments in the outer container are separated by a flattened and sealed portion of the polyethylene
摘要翻译： 设计了一种新的血液单元冷却系统，将血液快速冷却至约22°C，并将其保持在该温度即使在环境温度极端，持续数小时。 将包含在密封的柔性聚合物层中的包含98％十一烷醇，1.5％十四烷醇和0.5％1-癸醇（具有约23℃的熔点）的优选共晶溶液的系统用于冷却全血 填充袋。 优选的设计使用每个由透明聚乙烯片形成的内部和外部容器，其中内部隔室填充有溶液并密封，然后将其放置在外部容器中的每个隔间中，其中外部容器中的两个隔室被 扁平和密封的聚乙烯部分
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7.发明申请公开(公告)号：US20120197810A1
公开(公告)日：2012-08-02
申请号：US13358662
申请日：2012-01-26
CPC分类号： G06Q10/0832 , F25D3/08 , F25D3/14 , F25D2500/04 , G06Q30/012 , G06Q50/28
摘要： Disclosed is a process of selecting of a container and temperature-control system, such that biological products (including blood) requiring maintenance within a specified range of temperatures are so maintained during shipment. The process requires a prediction of the maximum period of shipment, and the predicted ambient temperature ranges and time of exposure thereto for the system during the period of shipment. With that information, a system of container(s) with temperature-control agents including dry ice, ice, frozen gel packs or a phase change material, is selected.
摘要翻译： 公开了一种选择容器和温度控制系统的方法，使得在运输期间维持在指定温度范围内需要维护的生物制品（包括血液）。 该过程需要预测装运期间的最大装运周期，以及预计的环境温度范围和系统暴露于其中的时间。 使用该信息，选择具有包括干冰，冰，冷冻凝胶包或相变材料在内的温度控制剂的容器系统。
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