公开(公告)号：US5306730A

公开(公告)日：1994-04-26

申请号：US887652

申请日：1992-05-26

申请人： Yoshitaka Nagai ,  Koutaro Takamizawa ,  Ryuichiro Tanaka ,  Hiroo Takayama ,  Toshizo Sakurai ,  Masahiko Mutai

发明人： Yoshitaka Nagai ,  Koutaro Takamizawa ,  Ryuichiro Tanaka ,  Hiroo Takayama ,  Toshizo Sakurai ,  Masahiko Mutai

IPC分类号： A61K31/20

CPC分类号： A61K31/20

摘要： A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.

摘要翻译： 包含至少一种碳原子数至少为12的脂肪酸的肉毒毒素中和剂。这种脂肪酸可以是饱和脂肪酸，如月桂酸，肉豆蔻酸，棕榈酸，硬脂酸，十九烷酸，花生四烯酸 酸和山萮酸或任何不饱和脂肪酸如油酸。 毒素中和剂的作用就好像是肉毒杆菌毒素的拮抗受体一样，当遇到肉毒杆菌毒素时，与毒素直接结合，使毒素与人体神经肌肉组织结合，防止肉毒杆菌爆发。 因此中和并附着于肉毒毒素中和剂的毒素从人体排出。 肉毒杆菌毒素中和剂可以从天然存在的甘油酯容易地和经济地制造，因此从已知的由牛脑产生的神经节苷脂GT1b的抗毒素成本远远低于成本。

公开(公告)号：US4771039A

公开(公告)日：1988-09-13

申请号：US844026

申请日：1986-03-25

申请人： Ryuichiro Tanaka ,  Koutaro Takamizawa ,  Hiroo Takayama ,  Toshizo Sakurai ,  Mitsuo Mada ,  Masahiko Mutai

发明人： Ryuichiro Tanaka ,  Koutaro Takamizawa ,  Hiroo Takayama ,  Toshizo Sakurai ,  Mitsuo Mada ,  Masahiko Mutai

IPC分类号： A61K35/20 ,  A61K31/00 ,  A61P39/02 ,  C07H15/10 ,  A61K31/70 ,  A61K31/685 ,  A61K35/48

CPC分类号： C07H15/10 ,  A61K31/00 ,  A61K35/20 ,  Y10S514/823

摘要： A botulinus toxin neutralizer comprising heat-treated fat globule membranes of animal milk or gangliosides isolated from fat globule membranes of animal milk. The neutralizer of the former nature is prepared from a material containing fat globules of animal milk by fractionating the material for separating the membranes of the fat globules from the rest of the material, and subjecting the separated fat globule membranes to heat treatment. The neutralizer of the former nature is prepared from a material containing fat globules by fractionating the material for separating the membranes of the fat globules from the rest of the material, and isolating gangliosides from the globule membranes.

摘要翻译： 一种肉毒杆菌毒素中和剂，其包含动物乳的热处理脂肪球膜或从动物乳的脂肪球膜分离的神经节苷脂。 前者性质的中和剂是由含有动物乳的脂肪球的材料制成的，分离用于将脂肪球的膜与其余材料分离的材料，并对分离的脂肪球膜进行热处理。 前者性质的中和剂由含有脂肪球的材料制备，通过分离用于将脂肪球的膜与其余材料分离的材料，并从球状膜中分离神经节苷脂。