公开(公告)号：US20070060754A1

公开(公告)日：2007-03-15

申请号：US10595230

申请日：2004-10-01

Applicant: Kyle Lindstrom ,  Bryon Merrill ,  Chad Haraldson ,  Michael Rice ,  Tushar Kshirsagar ,  Philip Heppner ,  Joshua Wurst ,  Shri Niwas ,  Sarah Johannessen

Inventor： Kyle Lindstrom ,  Bryon Merrill ,  Chad Haraldson ,  Michael Rice ,  Tushar Kshirsagar ,  Philip Heppner ,  Joshua Wurst ,  Shri Niwas ,  Sarah Johannessen

IPC: C07D471/00

CPC classification number: C07D471/04 ,  A61K31/4745 ,  C07D413/14 ,  C07D519/00 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463

Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Abstract translation: 含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物，中间体，制备方法，以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成， 在包括病毒和肿瘤的疾病的治疗中。

公开(公告)号：US20060111387A1

公开(公告)日：2006-05-25

申请号：US11275553

申请日：2006-01-13

Applicant: David Hays ,  Tushar Kshirsagar ,  Philip Heppner ,  Bryon Merrill ,  Michael Danielson ,  John Gerster ,  Chad Haraldson ,  Sarah Johannessen ,  Maureen Kavanagh ,  Kyle Lindstrom ,  Michael Rice ,  David Squire ,  Sarah Strong ,  Joshua Wurst

Inventor： David Hays ,  Tushar Kshirsagar ,  Philip Heppner ,  Bryon Merrill ,  Michael Danielson ,  John Gerster ,  Chad Haraldson ,  Sarah Johannessen ,  Maureen Kavanagh ,  Kyle Lindstrom ,  Michael Rice ,  David Squire ,  Sarah Strong ,  Joshua Wurst

IPC: A61K31/4745 ,  C07D487/02

CPC classification number: C07D471/04

Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Abstract translation: 公开了芳基取代的咪唑并喹啉化合物，含有化合物的化合物的药物组合物，中间体和这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤的疾病。

公开(公告)号：US20070259881A1

公开(公告)日：2007-11-08

申请号：US11570715

申请日：2005-06-17

Applicant: Joseph Dellaria ,  Tushar Kshirsagar ,  Shri Niwas ,  William Moser ,  Joan Moseman ,  Kyle Lindstrom ,  Azim Celebi ,  John Gerster ,  Philip Heppner ,  Joshua Wurst

Inventor： Joseph Dellaria ,  Tushar Kshirsagar ,  Shri Niwas ,  William Moser ,  Joan Moseman ,  Kyle Lindstrom ,  Azim Celebi ,  John Gerster ,  Philip Heppner ,  Joshua Wurst

IPC: A61K31/44 ,  A61K31/437 ,  A61K31/496 ,  A61P31/12 ,  A61P35/00 ,  C07D401/02 ,  C07D401/14 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: Imidazo ring systems, which include, for example, imidazopyridine, imidazoquinoline, 6,7,8,9-tetrahydroimidazoquinoline, imidazonaphthyridine, and 6,7,8,9-tetrahydroimidazonaphthyridine compounds substituted at the 1-position and/or the 2-position, pharmaceutical compositions containing these compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑环体系，其包括例如咪唑并吡啶，咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和6,7,8,9-四氢咪唑并吡啶化合物，其在1-位和/或2-位上被取代 公开了含有这些化合物的药物组合物，制备这些化合物的方法，以及这些化合物用作免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US20050282854A1

公开(公告)日：2005-12-22

申请号：US11200556

申请日：2005-08-10

Applicant: Philip Heppner ,  Kyle Lindstrom ,  Bryon Merrill

Inventor： Philip Heppner ,  Kyle Lindstrom ,  Bryon Merrill

IPC: A61K31/4745 ,  C07D471/02 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US20050197358A1

公开(公告)日：2005-09-08

申请号：US11101369

申请日：2005-04-07

Applicant: Kyle Lindstrom

Inventor： Kyle Lindstrom

IPC: A61K31/4745 ,  A61K31/541 ,  A61P37/02 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04

CPC classification number: A61K31/4745 ,  C07D471/04 ,  Y02A50/409

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US20070219228A1

公开(公告)日：2007-09-20

申请号：US11570703

申请日：2005-06-17

Applicant: Shri Niwas ,  Bryon Merrill ,  Philip Heppner ,  Tushar Kshirsagar ,  Gregory Lundquist ,  David Amos ,  Kyle Lindstrom

Inventor： Shri Niwas ,  Bryon Merrill ,  Philip Heppner ,  Tushar Kshirsagar ,  Gregory Lundquist ,  David Amos ,  Kyle Lindstrom

IPC: A61K31/4745 ,  C07D471/14

CPC classification number: C07D471/14

Abstract: Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 公开了用芳基取代基取代的咪唑并萘啶环体系，含有这些化合物的药物组合物，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US20070167481A1

公开(公告)日：2007-07-19

申请号：US11692701

申请日：2007-03-28

Applicant: Kyle Lindstrom

Inventor： Kyle Lindstrom

IPC: A61K31/4745

CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61K45/06 ,  C07D471/14 ,  A61K2300/00

Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

Abstract translation: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 还公开了制备可用于制备化合物的化合物和中间体的方法。

公开(公告)号：US20060252792A1

公开(公告)日：2006-11-09

申请号：US11459489

申请日：2006-07-24

Applicant: Joseph Dellaria ,  Kyle Lindstrom ,  Luke Dressel ,  Philip Heppner ,  John Jacobsen ,  Joan Moseman ,  William Moser ,  Matthew Radmer ,  Doris Stoermer

Inventor： Joseph Dellaria ,  Kyle Lindstrom ,  Luke Dressel ,  Philip Heppner ,  John Jacobsen ,  Joan Moseman ,  William Moser ,  Matthew Radmer ,  Doris Stoermer

IPC: C07D471/02 ,  A61K31/4745

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

Abstract translation: 在1位含有醚或硫醚官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。 还公开了制备可用于制备化合物的化合物和中间体的方法。

公开(公告)号：US20050032830A1

公开(公告)日：2005-02-10

申请号：US10916125

申请日：2004-08-11

Applicant: Joseph Dellaria ,  Kyle Lindstrom ,  Luke Dressel ,  Daniel Duffy ,  Philip Heppner ,  John Jacobsen ,  Joan Moseman ,  William Moser ,  Matthew Radmer ,  Doris Stoermer ,  Bernhard Zimmermann

Inventor： Joseph Dellaria ,  Kyle Lindstrom ,  Luke Dressel ,  Daniel Duffy ,  Philip Heppner ,  John Jacobsen ,  Joan Moseman ,  William Moser ,  Matthew Radmer ,  Doris Stoermer ,  Bernhard Zimmermann

IPC: A61K31/437 ,  A61K31/444 ,  A61K31/506 ,  A61K31/5377 ,  A61P7/00 ,  A61P17/00 ,  A61P17/14 ,  A61P17/16 ,  A61P25/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D471/04 ,  C07D471/14 ,  C07D471/02 ,  A61K31/4745

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

Abstract translation: 在1位含有醚或硫醚官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。 还公开了制备可用于制备化合物的化合物和中间体的方法。

公开(公告)号：US20050026943A1

公开(公告)日：2005-02-03

申请号：US10926385

申请日：2004-08-25

Applicant: John Gerster ,  Kyle Lindstrom ,  Gregory Marszalek ,  Michael Rice

Inventor： John Gerster ,  Kyle Lindstrom ,  Gregory Marszalek ,  Michael Rice

IPC: A61K31/424 ,  A61K31/429 ,  A61K31/4375 ,  A61K31/4738 ,  A61K31/5377 ,  A61P31/12 ,  A61P35/00 ,  A61P37/02 ,  C07D221/00 ,  C07D263/00 ,  C07D277/00 ,  C07D498/04 ,  C07D498/14 ,  C07D513/04 ,  C07D513/14 ,  C07D517/04 ,  C07D498/02 ,  A61K31/4745 ,  C07D491/02

CPC classification number: C07D513/04 ,  C07D513/14 ,  C07D517/04

Abstract: Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

Abstract translation: 描述了噻唑并恶唑并[s]噻唑并[4,5-c]喹啉-4-胺及其类似物，包括制造和使用新型中间体的方法。 这些化合物是免疫调节剂并诱导细胞因子生物合成，包括干扰素和/或肿瘤生物合成，坏死因子，并抑制T辅助2型免疫应答。 该化合物还可用于治疗病毒和肿瘤疾病。