利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.02 秒)

    System and method for drug delivery and microfluidic applications using microneedles
    3.
    发明授权
    System and method for drug delivery and microfluidic applications using microneedles 失效
    使用微针的药物递送和微流体应用的系统和方法

    公开(公告)号：US07560036B2

    公开(公告)日：2009-07-14

    申请号：US11133245

    申请日：2005-05-20

    申请人： Nevenka Golubovic-Liakopoulos ,  Glenn Fricano ,  Michael Danielson

    发明人： Nevenka Golubovic-Liakopoulos ,  Glenn Fricano ,  Michael Danielson

    IPC分类号： A61B17/20

    CPC分类号： B81C1/00111 ,  A61B17/205 ,  A61B2017/00526 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055

    摘要： The invention relates to a method of fabricating a microneedle array in a substrate, a drug delivery device comprising one or more microneedles extending upwards from the front surface of the substrate, the microneedles having a generally conical-shaped body defined by a plurality of surfaces sloping upwards from a relatively broad base to a tip, and one or more substances coating the microneedles, the one or more substances being operable to be administered to a patient, wherein the tips of the one or more microneedles are sufficiently sharp to penetrate an outer layer of the skin of the patient, and a method of administering one or more substances to a patient using the device.

    摘要翻译： 本发明涉及一种在衬底中制造微针阵列的方法，药物递送装置包括从衬底的前表面向上延伸的一个或多个微针，所述微针具有由倾斜的多个表面限定的大致圆锥形体 从相对宽的基部向上延伸至尖端，以及一种或多种涂覆微针的物质，所述一种或多种物质可操作地施用于患者，其中所述一个或多个微针的尖端足够锋利以穿透外层 的患者皮肤，以及使用该装置向患者施用一种或多种物质的方法。

    Substituted Chiral Fused [1,2]Imidazo[4,5-C] Ring Compounds
    5.
    发明申请
    Substituted Chiral Fused [1,2]Imidazo[4,5-C] Ring Compounds 有权
    取代手性稠合[1,2]咪唑并[4,5-C]环化合物

    公开(公告)号：US20080085895A1

    公开(公告)日：2008-04-10

    申请号：US11813052

    申请日：2005-12-29

    申请人： George Griesgraber ,  Tushar Kshirsagar ,  Sarah Slania ,  Michael Danielson

    发明人： George Griesgraber ,  Tushar Kshirsagar ,  Sarah Slania ,  Michael Danielson

    IPC分类号： A61K31/50 ,  A61K31/535 ,  A61P43/00 ,  C07D237/26 ,  C07D265/34 ,  C07D413/00

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—R1)— group in the fused ring at the 1-position of the imidazo ring, wherein R1 includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译： 取代的稠合[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[ 4,5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶）在稠环中具有-CH（-R 1 - N） - 基团 咪唑环的1-位，其中R 1包括官能团，例如酰胺，磺酰胺，脲，氨基甲酸酯，酯，酮，醚，前述的砜的硫代类似物 ，肟或羟胺，公开了含有化合物的药物组合物，中间体，制备该化合物的方法，以及这些化合物用作免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。 。

    Adaptive resonant switching power system
    6.
    发明申请
    Adaptive resonant switching power system 失效
    自适应谐振开关电源系统

    公开(公告)号：US20060152948A1

    公开(公告)日：2006-07-13

    申请号：US10541227

    申请日：2003-12-31

    申请人： Ping Tsui ,  Michael Danielson

    发明人： Ping Tsui ,  Michael Danielson

    IPC分类号： H02M3/335

    CPC分类号： H03F3/217 ,  H02M1/088 ,  H02M3/3382 ,  H02M2001/0058 ,  H02M2007/4818 ,  Y02B70/1433 ,  Y02B70/1441 ,  Y02B70/1491

    摘要： A resonant switching power system operates with two resonant frequencies. A first frequency depends on the secondary leakage inductance of an output transformer and capacitor. The first frequency varies with changes in the load because load changes alter the leakage inductance. A second resonant frequency depends on the gate source capacitance of two MOSFET power devices in the circuit and the leakage inductance of the circuit's driving transformer. Power is thereby supplied that is always in phase with the load so that switching in the power supply occurs when current is near zero. High thermal efficiency is thereby achieved.

    摘要翻译： 谐振开关电源系统以两个谐振频率工作。 第一个频率取决于输出变压器和电容器的二次漏电感。 第一个频率随负载变化而变化，因为负载变化会改变漏电感。 第二谐振频率取决于电路中两个MOSFET功率器件的栅极电源电容和电路驱动变压器的漏电感。 由此提供与负载始终相位的功率，使得当电流接近零时，电源的切换发生。 由此实现高热效率。