Surgical Anchor Delivery System
    4.
    发明申请
    Surgical Anchor Delivery System 审中-公开
    外科手术输送系统

    公开(公告)号:US20080188854A1

    公开(公告)日:2008-08-07

    申请号:US11969595

    申请日:2008-01-04

    IPC分类号: A61B17/16 A61B17/17

    摘要: Embodiments of the present invention relate to systems and methods for assisting a user during delivery of a labral anchor. For example, one embodiment provides a labral anchor delivery system that includes a drill sleeve having a proximal end and a distal end that is cannulated therebetween. At least a portion of the drill sleeve proximate to the distal end is curved such that the distal end is configured to be positioned substantially perpendicular to a surface of a glenoid. The labral anchor delivery system includes a drill bit having a proximal end and a distal end and configured to be positioned within the cannulated drill sleeve and into engagement with the surface of the glenoid. In addition, at least a portion of the drill bit between the proximal and distal ends of the drill bit is flexible for conforming to the curved portion of the drill sleeve.

    摘要翻译: 本发明的实施例涉及用于在递送拉帕尔锚的过程中辅助用户的系统和方法。 例如,一个实施例提供了一种唇部锚定器传送系统,其包括具有近端和在其间插管的远端的钻套筒。 靠近远端的钻孔套筒的至少一部分是弯曲的,使得远端构造成基本上垂直于关节盂的表面定位。 唇部锚固器输送系统包括具有近端和远端的钻头,并且被配置为定位在套管钻套内并与关节盂的表面接合。 此外,钻头的近端和远端之间的钻头的至少一部分是柔性的,以便与钻套筒的弯曲部分一致。

    Thermoelectric system
    5.
    发明申请
    Thermoelectric system 失效
    热电系统

    公开(公告)号:US20080072948A1

    公开(公告)日:2008-03-27

    申请号:US11803402

    申请日:2007-05-14

    IPC分类号: H01L35/30

    摘要: An internal combustion engine that includes a block, a cylinder head having an intake valve port and exhaust valve port formed therein, a piston, and a combustion chamber defined by the block, the piston, and the head. At least one thermoelectric device is positioned within either or both the intake valve port and the exhaust valve port. Each of the valves is configured to move within a respective intake and exhaust valve port thereby causing said valves to engage the thermoelectric devices resulting in heat transfer from the valves to the thermoelectric devices. The intake valve port and exhaust valve port are configured to fluidly direct intake air and exhaust gas, respectively, into the combustion chamber and the thermoelectric device is positioned within the intake valve port, and exhaust valve port, such that the thermoelectric device is in contact with the intake air and exhaust gas.

    摘要翻译: 一种内燃机,其包括块体,具有形成在其中的进气门口和排气阀口的气缸盖,活塞和由所述块,所述活塞和所述头部限定的燃烧室。 至少一个热电装置位于进气门口和排气阀口内的一个或两个内。 每个阀构造成在相应的进气和排气阀口内移动,从而使得所述阀与热电装置接合,导致从阀到热电装置的热传递。 进气门口和排气门口分别将进气和废气流体地引导到燃烧室中,并且热电装置位于进气阀口和排气阀口内,使得热电装置接触 与进气和废气。

    Sulfone substituted imidazo ring ethers
    7.
    发明申请
    Sulfone substituted imidazo ring ethers 失效
    砜取代的咪唑环醚

    公开(公告)号:US20070155767A1

    公开(公告)日:2007-07-05

    申请号:US10596117

    申请日:2004-12-03

    IPC分类号: A61K31/4745 C07D471/14

    CPC分类号: C07D471/04 C07D471/14

    摘要: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and 6,7,8,9-tetrahydroimidazonaphthyridines) with a sulfide-, sulfinyl-, or sulfonyl-containing ether substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

    摘要翻译: 咪唑环化合物(例如,咪唑并喹啉,6,7,8,9-四氢咪唑并喹啉,咪唑并吡啶和6,7,8,9-四氢咪唑并萘啶)与1-位硫醚基,亚磺酰基或磺酰基醚取代基 公开了含有化合物的药物组合物,中间体,制备该化合物的方法,以及这些化合物作为免疫调节剂的用途,用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

    Two-phase method for the synthesis of selected pyrazolopyrimidines
    9.
    发明授权
    Two-phase method for the synthesis of selected pyrazolopyrimidines 失效
    合成选择的吡唑并嘧啶的两相方法

    公开(公告)号:US07498434B2

    公开(公告)日:2009-03-03

    申请号:US10585006

    申请日:2004-12-02

    IPC分类号: C07D487/04 A61K31/519

    CPC分类号: C07D487/04

    摘要: An improved method of making a substituted pyrazolopyrimidine. The method comprises reacting a aminopyrazole compound or a salt thereof with a substituted 1-oxo-2-propenyl-arene(-heterocycle) or a salt thereof under acidic conditions in a reaction medium including a two-phase mixture of an aqueous solution and a water-immiscible organic liquid. Specific substituted pyrazolopyrimidines include N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide and N-methyl-N-(3-{3-[2-thienyl-carbonyl]-pyrazolo[1,5-a]-pyrimidin-7-yl}phenyl)acetamide.

    摘要翻译: 一种制备取代吡唑并嘧啶的改进方法。 该方法包括在酸性条件下将氨基吡唑化合物或其盐与取代的1-氧代-2-丙烯基 - 芳烃( - 杂环)或其盐在包括水溶液和 与水不混溶的有机液体。 特异取代的吡唑并嘧啶包括N- [3-(3-氰基吡唑并[1,5-a]嘧啶-7-基)苯基] -N-乙基乙酰胺和N-甲基-N-(3- {3- [2-噻吩基] 羰基] - 吡唑并[1,5-a]嘧啶-7-基}苯基)乙酰胺。