公开(公告)号：US07598382B2

公开(公告)日：2009-10-06

申请号：US11275553

申请日：2006-01-13

Applicant: David S. Hays ,  Tushar Kshirsagar ,  Philip D. Heppner ,  Bryon A. Merrill ,  Michael E. Danielson ,  John F. Gerster ,  Chad A. Haraldson ,  Sarah Johannessen ,  Maureen A. Kavanagh ,  Kyle J. Lindstrom ,  Michael J. Rice ,  David J. Squire ,  Sarah A. Strong ,  Joshua R. Wurst

Inventor： David S. Hays ,  Tushar Kshirsagar ,  Philip D. Heppner ,  Bryon A. Merrill ,  Michael E. Danielson ,  John F. Gerster ,  Chad A. Haraldson ,  Sarah Johannessen ,  Maureen A. Kavanagh ,  Kyle J. Lindstrom ,  Michael J. Rice ,  David J. Squire ,  Sarah A. Strong ,  Joshua R. Wurst

IPC: C07D471/00

CPC classification number: C07D471/04

Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Abstract translation: 公开了芳基取代的咪唑并喹啉化合物，含有化合物的化合物的药物组合物，中间体和这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤的疾病。

公开(公告)号：US20090221551A1

公开(公告)日：2009-09-03

申请号：US12281728

申请日：2007-03-14

Applicant: Tushar A. Kshirsagar ,  Karl J. Manske ,  Larry R. Krepski ,  Joan T. Moseman ,  George W. Griesgraber ,  Sarah Johannessen Slania ,  Philip D. Heppner

Inventor： Tushar A. Kshirsagar ,  Karl J. Manske ,  Larry R. Krepski ,  Joan T. Moseman ,  George W. Griesgraber ,  Sarah Johannessen Slania ,  Philip D. Heppner

IPC: A61K31/553 ,  C07D265/02 ,  A61K31/535 ,  C07D267/04 ,  C07D498/12 ,  A61K31/4355 ,  C07D239/00 ,  C07D471/02

CPC classification number: C07D498/14 ,  C07D471/14 ,  C07D471/22

Abstract: [1,2]Imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) substituted with a fused ring containing an oxygen and/or nitrogen atom attached at the 1- and/or 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: [1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，咪唑并[4,5-c]萘啶和咪唑并[4,5-c]吡啶） 含有在1-和/或2-位连接的氧和/或氮原子的稠环，含有化合物的药物组合物，中间体，制备化合物的方法以及这些化合物作为免疫调节剂的用途的方法，用于诱导 公开了动物中的细胞因子生物合成和包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：US08088788B2

公开(公告)日：2012-01-03

申请号：US12281728

申请日：2007-03-14

Applicant: Tushar A. Kshirsagar ,  Karl J. Manske ,  Larry R. Krepski ,  Joan T. Moseman ,  George W. Griesgraber ,  Sarah Johannessen Slania ,  Scott E. Langer ,  Philip D. Heppner

Inventor： Tushar A. Kshirsagar ,  Karl J. Manske ,  Larry R. Krepski ,  Joan T. Moseman ,  George W. Griesgraber ,  Sarah Johannessen Slania ,  Scott E. Langer ,  Philip D. Heppner

IPC: A61K31/4745 ,  C07D471/14

CPC classification number: C07D498/14 ,  C07D471/14 ,  C07D471/22

Abstract: [1,2]Imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) substituted with a fused ring containing an oxygen and/or nitrogen atom attached at the 1- and/or 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: [1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，咪唑并[4,5-c]萘啶和咪唑并[4,5-c]吡啶） 含有在1-和/或2-位连接的氧和/或氮原子的稠环，含有化合物的药物组合物，中间体，制备化合物的方法以及这些化合物作为免疫调节剂的用途的方法，用于诱导 公开了动物中的细胞因子生物合成和包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：US20070060754A1

公开(公告)日：2007-03-15

申请号：US10595230

申请日：2004-10-01

Applicant: Kyle Lindstrom ,  Bryon Merrill ,  Chad Haraldson ,  Michael Rice ,  Tushar Kshirsagar ,  Philip Heppner ,  Joshua Wurst ,  Shri Niwas ,  Sarah Johannessen

Inventor： Kyle Lindstrom ,  Bryon Merrill ,  Chad Haraldson ,  Michael Rice ,  Tushar Kshirsagar ,  Philip Heppner ,  Joshua Wurst ,  Shri Niwas ,  Sarah Johannessen

IPC: C07D471/00

CPC classification number: C07D471/04 ,  A61K31/4745 ,  C07D413/14 ,  C07D519/00 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463

Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Abstract translation: 含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物，中间体，制备方法，以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成， 在包括病毒和肿瘤的疾病的治疗中。

公开(公告)号：US20060111387A1

公开(公告)日：2006-05-25

申请号：US11275553

申请日：2006-01-13

Applicant: David Hays ,  Tushar Kshirsagar ,  Philip Heppner ,  Bryon Merrill ,  Michael Danielson ,  John Gerster ,  Chad Haraldson ,  Sarah Johannessen ,  Maureen Kavanagh ,  Kyle Lindstrom ,  Michael Rice ,  David Squire ,  Sarah Strong ,  Joshua Wurst

Inventor： David Hays ,  Tushar Kshirsagar ,  Philip Heppner ,  Bryon Merrill ,  Michael Danielson ,  John Gerster ,  Chad Haraldson ,  Sarah Johannessen ,  Maureen Kavanagh ,  Kyle Lindstrom ,  Michael Rice ,  David Squire ,  Sarah Strong ,  Joshua Wurst

IPC: A61K31/4745 ,  C07D487/02

CPC classification number: C07D471/04

Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Abstract translation: 公开了芳基取代的咪唑并喹啉化合物，含有化合物的化合物的药物组合物，中间体和这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤的疾病。

公开(公告)号：US20080070907A1

公开(公告)日：2008-03-20

申请号：US11827648

申请日：2007-07-12

Applicant: George Griesgraber ,  Sarah Johannessen Slania

Inventor： George Griesgraber ,  Sarah Johannessen Slania

IPC: A61K31/5365 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07D498/14 ,  C07D498/22

CPC classification number: C07D498/14

Abstract: Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) with a —CH(—R2)— group in the fused ring at the 2-position of the imidazo ring and a —CH(—R1)— group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 取代的稠合[1,2]咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c]喹啉，咪唑并[ 4,5-c]萘啶，6,7,8,9-四氢咪唑并[4,5-c]萘啶和咪唑并[4,5-c]吡啶），其中-CH（-R 2） 在咪唑环的1位上的稠合环中的咪唑环的2-位的稠合环中的-CH 2 - （CH 2 - ） - 基团和-CH（-R 1） 公开了含有化合物的药物组合物，制备该化合物的方法，以及这些化合物用作免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US20080015184A1

公开(公告)日：2008-01-17

申请号：US11570567

申请日：2005-06-14

Applicant: Tushar Kshirsagar ,  George Griesgraber ,  Sarah Johannessen ,  Azim Celebi ,  Philip Heppner ,  Gregory Lundquist Jr. ,  David Amos ,  Bernhard ZImmermann ,  Scott Langer

Inventor： Tushar Kshirsagar ,  George Griesgraber ,  Sarah Johannessen ,  Azim Celebi ,  Philip Heppner ,  Gregory Lundquist Jr. ,  David Amos ,  Bernhard ZImmermann ,  Scott Langer

IPC: A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61P31/12 ,  A61P35/00 ,  C07D243/08 ,  C07D279/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having a urea substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物在2-位上具有尿素取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。