摘要:
Compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: wherein Z is N or CH or the Z(R1) part is replaced with a covalent bond, m and n is 0, 1, 2 or 3; HET is heteroaryl; X is CF3, halogen, CO-heterocyclyl, COOR3 or CONHR3; R1 is H, (CH2)o-aryl, (CH2)p-heteroaryl, (CH2)q-biphenyl; C(O)—R5; S(O)2—R6; R2 is H, aryl, heteroaryl, Y—(CH2)r-aryl, Y—(CH2)s-heteroaryl, where some of the above substituents may be substituted; Y is O or S; with the exclusion of the compound where HET is 1,3-thiazol, X is COOH, R1 is 4-fluorophenyl and R2 is benzyloxy. The invention also relates to the use of a compound of general formula (I), salts or solvates thereof for the use in the prevention or treatment of diseases where the activation of MMPs is involved in the pathomechanism. In this aspect the use of the above excluded compound is also inventive.
摘要:
A subscriber portfolio model is created by forming mutually exclusive and completely exhaustive groups of subscribers in a way that maximizes the intra-group similarity and inter-group dissimilarity of the value of a target attribute among subscribers in the groups. The subscriber groups thus generated are self-descriptive, as the groups are defined by the attributes used to form them. A segmenting algorithm groups subscribers along permutations of attributes. Relevant data about subscribers is collected from various sources, correlated, and subscriber identities removed to ensure privacy. After analyzing the aggregated data, a subscriber portfolio model is built. The subscriber portfolio model is created in an iterative process, where in each step, a selected subscriber group is subdivided into smaller subscriber groups along different value ranges of a statistically decisive attribute that is selected and evaluated based on specific methods. The subdivision is performed by computing filtering conditions based on an in-depth statistical analysis.
摘要:
A method and apparatus for controlling data traffic in a communications network. The server determines that network conditions are suitable for sending delay tolerant data traffic, and as a result of the determination, it transmits a grant message to at least one client device, the grant message informing the client device that it is permitted to send or receive delay tolerant data traffic.
摘要:
The present disclosure relates to a technique for configuring and collecting network performance measurements in a mobile communications network, the mobile communications network comprising at least one network node and at least one mobile terminal 208 connected to the at least one network node, implementing a Minimization of Drive Tests (MDT) trace measurement configuration and collection. A method embodiment comprises the steps of performing, in the at least one mobile terminal 208, a service specific measurement based on a service specific measurement configuration, wherein the service specific measurement includes determining one or more quality metrics related to at least one of one or more services, one or more service types, one or more bearers, one or more applications and one or more application types provided in the mobile communications network, to obtain a result of the performed service specific measurement and generating, in the at least one mobile terminal 208, active test traffic based on an active measurement configuration to perform an active measurement, wherein the active measurement uses the generated test traffic to obtain a result of the performed active measurement, the result of the performed active measurement indicating the performance of the test traffic in the mobile communications network.
摘要:
A subscriber portfolio model is created by forming mutually exclusive and completely exhaustive groups of subscribers in a way that maximizes the intra-group similarity and inter-group dissimilarity of the value of a target attribute among subscribers in the groups. The subscriber groups thus generated are self-descriptive, as the groups are defined by the attributes used to form them. A segmenting algorithm groups subscribers along permutations of attributes. Relevant data about subscribers is collected from various sources, correlated, and subscriber identities removed to ensure privacy. After analyzing the aggregated data, a subscriber portfolio model is built. The subscriber portfolio model is created in an iterative process; in each step, a selected subscriber group is subdivided into smaller subscriber groups along different value ranges of a statistically decisive attribute that is selected and evaluated based on specific methods. The subdivision is performed by computing filtering conditions based on an in-depth statistical analysis.
摘要:
A network management system (100) and a method are described herein that are capable of identifying and accessing Quality of Service (QoS) issues within a communications network (104, 106). In one application, the network management system (100) includes a service performance unit (108), a service performance database (110), a factor scoring system (112), a factor score database (114) and a factor strength analysis module (116).
摘要:
A passive network measurement based solution for estimating user-perceived TCP throughput in a mobile PS network is provided. Instead of direct detection of TCP bulk data periods and server side limitations, the diversity of TCP connection end-points on the Internet side is exploited. The TCP throughput at an interface of the mobile network from/to each server on the Internet side during a file/object transfer of bulk date periods is monitored and measured and the servers are ranked according to their throughput statistics. The top performing servers are grouped into classes by statistical algorithms. The throughput samples from the users towards the servers belonging to the top group of highest average throughput are averaged to obtain a proper estimation for the user-perceived TCP throughput.
摘要:
In existing mobile networks, users may be traced to troubleshoot problematic user connections, monitor generic network performance, and to perform root cause analysis to identify network problems. However, the existing tracing methods provide incomplete trace information. To address this and other issues, early tracing recording is enabled in which an involved trace entity starts recording the trace data when any initial activity related to the user equipment is detected. The trace entity can continue the trace if a trace trigger is later confirmed or may discard the trace data if the trigger is not confirmed.
摘要:
A remote controllable automatic apparatus for preparing fried potato product from dehydrated potato, frying the potato product prepared with addition of at least water in subsequent operational cycles. The apparatus comprising a frying unit with a frying oil container and electric means for heating the frying oil; and also including electronic sensors (2) for measuring and storage devices for registering selected parameters of the frying process. Further comprises a status register (3) for storing status data and frying parameters relating to actual and former operational cycles, and also enabling data; and an interface (4) connected to a telecommunication network (7) for on-line transmitting and for on-line modifying the status register (3) content.
摘要:
A network management system (100) and a method are described herein that are capable of identifying and accessing Quality of Service (QoS) issues within a communications network (104, 106). In one application, the network management system (100) includes a service performance unit (108), a service performance database (110), a factor scoring system (112), a factor score database (114) and a factor strength analysis module (116).