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    Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells
    1.
    发明授权
    Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells 有权
    鉴定用于预测与乳腺细胞相互作用和/或调节蛋白酪氨酸激酶和/或蛋白酪氨酸激酶途径的化合物的活性的多核苷酸

    公开(公告)号：US07537891B2

    公开(公告)日：2009-05-26

    申请号：US11072175

    申请日：2005-03-04

    申请人： Fei Huang ,  Xia Han ,  Karen A. Reeves ,  Lukas C. Amler ,  Craig R. Fairchild ,  Francis Y. Lee ,  Peter Shaw

    发明人： Fei Huang ,  Xia Han ,  Karen A. Reeves ,  Lukas C. Amler ,  Craig R. Fairchild ,  Francis Y. Lee ,  Peter Shaw

    IPC分类号： C12Q1/00 ,  C12Q1/68

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The present invention describes polynucleotides that have been discovered to correlate to the relative sensitivity or resistance of cells, e.g., breast cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, members of the Src family of tyrosine kinases, e.g., Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn, as well as other protein tyrosine kinases, including, Bcr-abl, Jak, PDGFR, c-kit and Eph receptors. These polynucleotides have been shown to have utility in predicting the resistance and sensitivity of breast cell lines to the compounds. Such polynucleotides comprise polynucleotide predictor or marker sets useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas, e.g., breast cancer, in which signaling through one or more of the aforementioned Src tyrosine and protein tyrosine kinases is involved with the disease process.

    摘要翻译： 本发明描述了已被发现与将细胞例如乳腺细胞系的相对敏感性或抗性相关的多核苷酸与用蛋白酪氨酸激酶相互作用并调节，例如抑制蛋白酪氨酸激酶的化合物的治疗， 酪氨酸激酶Src家族成员，如Src，Fgr，Fyn，Yes，Blk，Hck，Lck和Lyn，以及其他蛋白酪氨酸激酶，包括Bcr-abl，Jak，PDGFR，c-kit和Eph 受体。 已经显示这些多核苷酸可用于预测乳腺细胞系对化合物的抗性和敏感性。 这样的多核苷酸包括可用于预测药物反应的方法的多核苷酸预测物或标志物组，以及疾病管理中的预后或诊断指标，特别是在那些疾病领域，例如乳腺癌中，其中通过一种或多种上述Src酪氨酸和 蛋白酪氨酸激酶参与疾病过程。

    Methods of using EPHA2 for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells
    7.
    发明授权
    Methods of using EPHA2 for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells 有权
    使用EPHA2预测与乳腺细胞相互作用和/或调节蛋白酪氨酸激酶和/或蛋白酪氨酸激酶途径的化合物的活性的方法

    公开(公告)号：US07504211B2

    公开(公告)日：2009-03-17

    申请号：US10648593

    申请日：2003-08-26

    申请人： Fei Huang ,  Xia Han ,  Karen A. Reeves ,  Lukas C. Amler ,  Craig R. Fairchild ,  Francis Y. Lee ,  Peter Shaw

    发明人： Fei Huang ,  Xia Han ,  Karen A. Reeves ,  Lukas C. Amler ,  Craig R. Fairchild ,  Francis Y. Lee ,  Peter Shaw

    IPC分类号： C12Q1/00 ,  C12Q1/68

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The present invention describes polynucleotides that have been discovered to correlate to the relative sensitivity or resistance of cells, e.g., breast cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, members of the Src family of tyrosine kinases, e.g., Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn, as well as other protein tyrosine kinases, including, Bcr-abl, Jak, PDGFR, c-kit and Eph receptors. These polynucleotides have been shown to have utility in predicting the resistance and sensitivity of breast cell lines to the compounds. Such polynucleotides comprise polynucleotide predictor or marker sets useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas, e.g., breast cancer, in which signaling through one or more of the aforementioned Src tyrosine and protein tyrosine kinases is involved with the disease process.

    摘要翻译： 本发明描述了已被发现与将细胞例如乳腺细胞系的相对敏感性或抗性相关的多核苷酸与用蛋白酪氨酸激酶相互作用并调节，例如抑制蛋白酪氨酸激酶的化合物的治疗， 酪氨酸激酶Src家族成员，如Src，Fgr，Fyn，Yes，Blk，Hck，Lck和Lyn，以及其他蛋白酪氨酸激酶，包括Bcr-abl，Jak，PDGFR，c-kit和Eph 受体。 已经显示这些多核苷酸可用于预测乳腺细胞系对化合物的抗性和敏感性。 这样的多核苷酸包括可用于预测药物反应的方法的多核苷酸预测物或标志物组，以及疾病管理中的预后或诊断指标，特别是在那些疾病领域，例如乳腺癌中，其中通过一种或多种上述Src酪氨酸和 蛋白酪氨酸激酶参与疾病过程。