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1.发明授权Diphenylurea derivatives and their use as chloride channel blockers or BKCa channel modulators 失效二苯基脲衍生物及其作为氯化物通道阻断剂或BKCa通道调节剂的用途公开(公告)号：US07985761B2
公开(公告)日：2011-07-26
申请号：US12280490
申请日：2007-03-09
IPC分类号： A61K31/4245 , C07D271/07
CPC分类号： C07D271/07
摘要： The present invention relates to novel diphenylurea derivatives useful as chloride channel blockers or BKCa channel modulators.In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作氯化物通道阻断剂或BKCa通道调节剂的新型二苯基脲衍生物。 在其他方面，本发明涉及这些化合物在治疗方法中的用途，以及包含本发明化合物的药物组合物。
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2.发明申请DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS OR BKCa CHANNEL MODULATORS 失效二氯乙烯衍生物及其作为氯离子通道阻滞剂或BKCa通道调节剂公开(公告)号：US20090018172A1
公开(公告)日：2009-01-15
申请号：US12280490
申请日：2007-03-09
IPC分类号： A61K31/4245 , C07D271/07 , A61P35/04 , A61P19/00
CPC分类号： C07D271/07
摘要： The present invention relates to novel diphenylurea derivatives useful as chloride channel blockers or BKCa channel modulators.In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作氯化物通道阻断剂或BKCa通道调节剂的新型二苯基脲衍生物。 在其他方面，本发明涉及这些化合物在治疗方法中的用途，以及包含本发明化合物的药物组合物。
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3.发明申请NOVEL 1,4- AND 1,5-DIARYLSUBSTITUTED 1,2,3-TRIAZOLES USEFUL AS POTASSIUM CHANNEL MODULATORS 审中-公开新型1,4-和1,5-二磺基-1,2,3-三唑作为钾通道调节剂有用公开(公告)号：US20100105689A1
公开(公告)日：2010-04-29
申请号：US12523541
申请日：2008-01-17
申请人： Antonio Nardi , Morten Grunnet , Joachim Demnitz , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Morten Grunnet , Joachim Demnitz , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
IPC分类号： A61K31/53 , C07D271/06 , A61K31/4245 , C07D257/04 , A61K31/41 , A61P11/00 , A61P25/00 , A61P9/00 , A61P3/00 , A61P35/00 , A61K31/496 , A61K31/4985
CPC分类号： C07D413/10 , C07D403/10
摘要： This invention relates to novel 1,4- and 1,5-diarylsubstituted 1,2,3-triazole derivatives that are found to be potent modulators of potassium channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of potassium channels.
摘要翻译： 本发明涉及被发现是钾通道的有效调节剂的新的1,4-和1,5-二芳基取代的1,2,3-三唑衍生物，因此它们是治疗疾病或病症的有价值的候选物， 与对钾通道调节有反应的那些不同。
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4.发明授权Carbonylamino derivatives useful for the treatment of certain inflammatory disorders 有权用于治疗某些炎性疾病的羰基氨基衍生物公开(公告)号：US08455549B2
公开(公告)日：2013-06-04
申请号：US12674746
申请日：2008-08-21
IPC分类号： A61K31/165 , A61P1/04
CPC分类号： A61K31/165
摘要： The present invention relates to the use of a particular group of carbonylamino derivatives for the treatment or alleviation of a disease or condition relating to certain inflammatory disorders.
摘要翻译： 本发明涉及特定的一组羰基氨基衍生物用于治疗或减轻与某些炎性疾病有关的疾病或病症的用途。
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公开(公告)号：US20100137387A1
公开(公告)日：2010-06-03
申请号：US12598533
申请日：2008-04-29
申请人： Antonio Nardi , Jeppe Kejser Christensen , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Jeppe Kejser Christensen , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
CPC分类号： C07D257/04
摘要： This invention relates to novel β-keto-amide derivatives that are found to be potent modulators of ion channels, and in particular potassium channels and chloride channels, and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
摘要翻译： 本发明涉及被发现是离子通道的有效调节剂，特别是钾通道和氯化物通道的新型的β-酮酰胺衍生物，因此，它们是用于治疗疾病或病症的有价值的候选物， 那些响应于钾通道调节的那些。
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6.发明申请NOVEL AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS 审中-公开新型芳香杂环羧酸酰胺衍生物作为钾通道调节剂有用公开(公告)号：US20100137312A1
公开(公告)日：2010-06-03
申请号：US12600159
申请日：2008-05-13
申请人： Antonio Nardi , Jeppe Kejser Christensen , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Jeppe Kejser Christensen , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
IPC分类号： A61K31/41 , C07D405/02 , C07D403/02 , C07D307/02 , C07D413/02 , C07D413/14 , A61K31/34 , A61K31/4245 , A61K31/454 , A61K31/5377 , A61P25/00 , A61P35/00 , A61P1/00 , A61P29/00
CPC分类号： C07D405/12 , C07D307/68 , C07D403/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： This invention relates to novel aromatic heterocyclic carboxylic acid amide derivatives of formula (I) that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
摘要翻译： 本发明涉及式（I）的新型芳族杂环羧酸酰胺衍生物，其被发现是钾通道的有效调节剂，因此是用于治疗疾病或病症的有价值的候选物， 调节钾通道。
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公开(公告)号：US20100099732A1
公开(公告)日：2010-04-22
申请号：US12532264
申请日：2008-03-14
申请人： Antonio Nardi , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbaek , Lars Siim Madsen
发明人： Antonio Nardi , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbaek , Lars Siim Madsen
IPC分类号： A61K31/40
CPC分类号： A61K31/405 , C07D209/42
摘要： This invention relates to pharmaceutical compositions comprising phenylcarbamoyl-methyl-indole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.
摘要翻译： 本发明涉及包含苯基氨基甲酰基 - 甲基 - 吲哚衍生物的药物组合物，其被发现是钾通道的有效调节剂，因此是用于治疗疾病或病症的有价值的候选物，其与对钾的调节有关 频道
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8.发明申请NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS 审中-公开作为离子通道调制器有用的新型的CINNAMIC AMIDE衍生物公开(公告)号：US20100087496A1
公开(公告)日：2010-04-08
申请号：US12519683
申请日：2007-12-17
申请人： Antonio Nardi , Morten Grunnet , Joachim Demnitz , Thomas Diness Jensen , Palle Christophersen , David Spencer Jones , Elsebet Ostergaard Nielsen , Dorte Strobaek , Lars Siim Madsen
发明人： Antonio Nardi , Morten Grunnet , Joachim Demnitz , Thomas Diness Jensen , Palle Christophersen , David Spencer Jones , Elsebet Ostergaard Nielsen , Dorte Strobaek , Lars Siim Madsen
IPC分类号： A61K31/165 , C07C233/01 , C07D257/04 , A61K31/41 , A61P15/00
CPC分类号： C07C309/15 , C07C1/26 , C07C17/10 , C07C311/08 , C07C311/09 , C07C311/21 , C07C311/46 , C07C311/51 , C07C2529/40 , C07C9/00 , C07C19/075
摘要： This invention relates to novel cinnamic amide derivatives that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of ion channels.
摘要翻译： 本发明涉及被认为是离子通道的有效调节剂的新型肉桂酰胺衍生物，因此，它们是用于治疗与对离子通道调节有反应的疾病或病症多种多样的有价值的候选物。
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9.发明申请CARBONYLAMINO DERIVATIVES USEFUL FOR THE TREATMENT OF CERTAIN INFLAMMATORY DISORDERS 有权用于治疗某些炎症性疾病的碳云母衍生物公开(公告)号：US20110124735A1
公开(公告)日：2011-05-26
申请号：US12674746
申请日：2008-08-21
IPC分类号： A61K31/165 , A61P29/00 , A61P25/28 , A61P1/00
CPC分类号： A61K31/165
摘要： The present invention relates to the use of a particular group of carbonylamino derivatives for the treatment or alleviation of a disease or condition relating to certain inflammatory disorders.
摘要翻译： 本发明涉及特定的一组羰基氨基衍生物用于治疗或减轻与某些炎性疾病有关的疾病或病症的用途。
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10.发明申请公开(公告)号：US20100144809A1
公开(公告)日：2010-06-10
申请号：US12599196
申请日：2008-05-07
申请人： Antonio Nardi , Joachim Demnitz , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
发明人： Antonio Nardi , Joachim Demnitz , Morten Grunnet , Palle Christophersen , David Spencer Jones , Elsebet Østergaard Nielsen , Dorte Strøbæk , Lars Siim Madsen
IPC分类号： A61K31/41 , C07D257/04 , A61P11/00 , A61P25/08 , A61P25/00 , A61P13/10 , A61P15/10 , A61P15/00 , A61P13/00 , A61P25/18 , A61P25/16 , A61P25/24 , A61P27/00 , A61P17/14
CPC分类号： C07D257/04 , C07D403/10
摘要： This invention relates to novel benzamidine derivatives of formula (I) that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels. A stereoisomer or a mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically-acceptable addition salt thereof, wherein B may be absent (i.e. no heterocyclic ring is formed); and when absent, the nitrogen next to B holds a hydrogen (i.e. “NH”), and A represents NH2 or OH; or B may be present (i.e. forms part of a heterocyclic ring); and when present, B represents C═O or C═S; and A represents NH or O; and wherein the rest of variables are as specified in claim 1.
摘要翻译： 本发明涉及式（I）的新型苄脒衍生物，其被发现是钾通道的有效调节剂，因此是治疗与钾通道调节有关的疾病或病症多种多样的有价值的候选物 。 其立体异构体或其立体异构体或其N-氧化物或其药学上可接受的加成盐的混合物，其中B可以不存在（即没有形成杂环）; 当不存在时，B旁边的氮保持氢（即“NH”），A表示NH 2或OH; 或B可以存在（即形成杂环的一部分）; 当存在时，B表示C = O或C = S; A表示NH或O; 并且其中其余的变量如权利要求1所述。
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