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公开(公告)号:US20160106842A1
公开(公告)日:2016-04-21
申请号:US14779939
申请日:2014-03-06
申请人: Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-Munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura WEST , Thomas ZABAWA , Junping ZHAO
发明人: Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC分类号: A61K47/18 , C12N15/113 , A61K38/22 , C07D295/096 , C07D205/04 , C07C235/42 , A61K47/22 , C07C229/14 , C07C229/12 , C07D213/79 , C07D213/69 , C07C217/58 , C07D317/28
CPC分类号: A61K47/18 , A61K9/0019 , A61K9/1272 , A61K9/5123 , A61K31/713 , A61K38/2264 , A61K47/22 , A61K48/00 , C07C217/58 , C07C219/06 , C07C229/12 , C07C229/14 , C07C235/42 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/28 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
摘要翻译: 本发明提供式(I)化合物或其药学上可接受的盐,其中R 1 -R 4,L和X如本文所定义。 式(I)化合物及其药学上可接受的盐是可用于将生物活性剂递送至细胞和组织的阳离子脂质。
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公开(公告)号:US20110200582A1
公开(公告)日:2011-08-18
申请号:US12974906
申请日:2010-12-21
申请人: Jeremy BARYZA , Keith BOWMAN , Andrew GEALL , Tanzina LABONTE , Cameron LEE , Chandra VARGEESE , Laura WEST , Junping ZHAO
发明人: Jeremy BARYZA , Keith BOWMAN , Andrew GEALL , Tanzina LABONTE , Cameron LEE , Chandra VARGEESE , Laura WEST , Junping ZHAO
IPC分类号: A61K39/395 , A61K47/06 , C07J43/00 , A61P35/00 , A61K47/28 , C07D303/24 , C07C43/178 , C07C271/16 , A61K31/575 , A61K38/02 , A61K31/7088 , A61K38/43
CPC分类号: A61K9/127 , A61K9/1272 , A61K31/7088 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/30 , A61K2300/00 , C07J9/00 , C07J31/006 , C07J41/0055 , C07J43/003
摘要: Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.
摘要翻译: 公开了用于将治疗有效量的生物活性剂递送到肝,肿瘤和/或其它细胞或组织的制剂和优化方案。 还提供了式(I)的阳离子脂质化合物的组合物和用途。 本发明还涉及式(XI)的隐形脂质的组合物和用途。 还提供了制备这种化合物,组合物和制剂以及这些化合物,组合物和制剂的方法和用途以将生物活性剂递送至细胞和/或组织的方法。
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公开(公告)号:US09301923B2
公开(公告)日:2016-04-05
申请号:US14197124
申请日:2014-03-04
申请人: Jeremy Baryza , Keith Bowman , Andrew Geall , Tanzina Labonte , Cameron Lee , Chandra Vargeese , Laura West , Junping Zhao
发明人: Jeremy Baryza , Keith Bowman , Andrew Geall , Tanzina Labonte , Cameron Lee , Chandra Vargeese , Laura West , Junping Zhao
IPC分类号: A61K31/575 , A61K47/06 , A61K9/127 , A61K31/7088 , A61K47/18 , A61K47/28 , A61K47/30 , C07J9/00 , C07J41/00 , C07J43/00 , A61K47/14 , C07J31/00
CPC分类号: A61K9/127 , A61K9/1272 , A61K31/7088 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/30 , A61K2300/00 , C07J9/00 , C07J31/006 , C07J41/0055 , C07J43/003
摘要: Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.
摘要翻译: 公开了用于将治疗有效量的生物活性剂递送到肝,肿瘤和/或其它细胞或组织的制剂和优化方案。 还提供了式(I)的阳离子脂质化合物的组合物和用途。 本发明还涉及式(XI)的隐形脂质的组合物和用途。 还提供了制备这种化合物,组合物和制剂以及这些化合物,组合物和制剂的方法和用途以将生物活性剂递送至细胞和/或组织的方法。
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公开(公告)号:US20140309277A1
公开(公告)日:2014-10-16
申请号:US14197124
申请日:2014-03-04
申请人: Jeremy BARYZA , Keith BOWMAN , Andrew GEALL , Tanzina LABONTE , Cameron LEE , Chandra VARGEESE , Laura WEST , Junping ZHAO
发明人: Jeremy BARYZA , Keith BOWMAN , Andrew GEALL , Tanzina LABONTE , Cameron LEE , Chandra VARGEESE , Laura WEST , Junping ZHAO
IPC分类号: A61K9/127 , A61K47/14 , A61K31/7088 , A61K47/28
CPC分类号: A61K9/127 , A61K9/1272 , A61K31/7088 , A61K47/14 , A61K47/18 , A61K47/28 , A61K47/30 , A61K2300/00 , C07J9/00 , C07J31/006 , C07J41/0055 , C07J43/003
摘要: Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I). The invention also relates to compositions and uses for stealth lipids of formula (XI). Also provided are processes for making such compounds, compositions, and formulations, plus methods and uses of such compounds, compositions, and formulations to deliver biologically active agents to cells and/or tissues.
摘要翻译: 公开了用于将治疗有效量的生物活性剂递送到肝,肿瘤和/或其它细胞或组织的制剂和优化方案。 还提供了式(I)的阳离子脂质化合物的组合物和用途。 本发明还涉及式(XI)的隐形脂质的组合物和用途。 还提供了制备这种化合物,组合物和制剂以及这些化合物,组合物和制剂的方法和用途以将生物活性剂递送至细胞和/或组织的方法。
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