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公开(公告)号：US20140303232A1
公开(公告)日：2014-10-09
申请号：US14200359
申请日：2014-03-07
申请人： Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura Ellen West , Thomas ZABAWA , Junping ZHAO
发明人： Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura Ellen West , Thomas ZABAWA , Junping ZHAO
IPC分类号： A61K47/18 , A61K47/12 , A61K47/14 , C12N15/113 , A61K47/22
CPC分类号： A61K47/18 , A61K9/1271 , A61K9/1272 , A61K47/183 , A61K47/22 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/24 , C07D317/28 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，其中R 1 -R 4，L和X如本文所定义。 式（I）化合物及其药学上可接受的盐是可用于将生物活性剂递送至细胞和组织的阳离子脂质。
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公开(公告)号：US09504747B2
公开(公告)日：2016-11-29
申请号：US14200359
申请日：2014-03-07
申请人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , C07C229/12 , A61K47/22 , A61K9/127 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C235/46 , C07C237/08 , C07D213/79 , C07D317/24 , C07D317/28 , C07D205/04 , C07D295/096 , C07D213/69 , C12N15/113
CPC分类号： A61K47/18 , A61K9/1271 , A61K9/1272 , A61K47/183 , A61K47/22 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/24 , C07D317/28 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US20160106842A1
公开(公告)日：2016-04-21
申请号：US14779939
申请日：2014-03-06
申请人： Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-Munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura WEST , Thomas ZABAWA , Junping ZHAO
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , C12N15/113 , A61K38/22 , C07D295/096 , C07D205/04 , C07C235/42 , A61K47/22 , C07C229/14 , C07C229/12 , C07D213/79 , C07D213/69 , C07C217/58 , C07D317/28
CPC分类号： A61K47/18 , A61K9/0019 , A61K9/1272 , A61K9/5123 , A61K31/713 , A61K38/2264 , A61K47/22 , A61K48/00 , C07C217/58 , C07C219/06 , C07C229/12 , C07C229/14 , C07C235/42 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/28 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，其中R 1 -R 4，L和X如本文所定义。 式（I）化合物及其药学上可接受的盐是可用于将生物活性剂递送至细胞和组织的阳离子脂质。
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公开(公告)号：US20170196979A1
公开(公告)日：2017-07-13
申请号：US15277402
申请日：2016-09-27
申请人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
发明人： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC分类号： A61K47/18 , C12N15/113 , A61K47/22
CPC分类号： A61K47/18 , A61K9/1271 , A61K9/1272 , A61K47/183 , A61K47/22 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/24 , C07D317/28 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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