公开(公告)号：US20130022557A1

公开(公告)日：2013-01-24

申请号：US13189000

申请日：2011-07-22

Applicant: Cheri Lynn Swanson ,  Tomohiro Hakozaki ,  Leo Timothy Laughlin, II

Inventor： Cheri Lynn Swanson ,  Tomohiro Hakozaki ,  Leo Timothy Laughlin, II

IPC: A61K36/03 ,  A61Q19/02 ,  A61Q1/02 ,  A61Q17/04

CPC classification number: A61K8/97 ,  A61K36/03 ,  A61K2800/87 ,  A61Q19/02

Abstract: A method of improving the appearance of a hyperpigmented spot may comprise the step of applying a composition comprising a safe and effective amount of an Laminaria Saccharina extract to a hyperpigmented spot on a skin surface, wherein the composition is applied for a period of time sufficient for the Laminaria Saccharina extract to improve the appearance of the hyperpigmented spot. The method may include the step of identifying a hyperpigmented spot on a facial skin surface. Other methods as disclosed include a method for improving the appearance of post-inflammatory hyperpigmentation.

Abstract translation: 改善色素沉着斑点的外观的方法可以包括将包含安全有效量的粘蛋白提取物的组合物施用于皮肤表面上色素沉着斑点的步骤，其中所述组合物施用足够的时间 Laminaria Saccharina提取物，以改善色素沉着斑的外观。 该方法可以包括识别面部皮肤表面上色素沉着斑点的步骤。 所公开的其它方法包括改善炎症后色素沉着过度的外观的方法。

公开(公告)号：US20120156146A1

公开(公告)日：2012-06-21

申请号：US13299042

申请日：2011-11-17

Applicant: Tomohiro HAKOZAKI ,  Leo Timothy Laughlin, II

Inventor： Tomohiro HAKOZAKI ,  Leo Timothy Laughlin, II

IPC: A61K8/34 ,  A61P29/00 ,  A61K8/368 ,  A61K8/97 ,  A61K8/67 ,  A61K8/42 ,  A61Q17/04 ,  A61K8/60

Abstract: A method of improving the appearance of facial texture may comprise the step of applying a composition comprising an effective amount of a material that regulates hyaluronic acid synthesis to an area of textured facial skin, wherein the composition is applied for a period of time sufficient for the material to improve the appearance of the facial texture. In some embodiments, the material that regulates hyaluronic acid synthesis is hexyldecanol. The method may also include the step of identifying facial texture on a facial skin surface. In particular embodiments, the facial skin texture is selected from the group consisting of macro-texture, micro-texture, and combinations thereof.

Abstract translation: 改善面部纹理外观的方法可以包括将包含有效量的调节透明质酸合成的材料的组合物施用到织构化的面部皮肤的区域的步骤，其中将组合物施用足够的时间 材质以改善面部纹理的外观。 在一些实施方案中，调节透明质酸合成的材料是己基癸醇。 该方法还可以包括识别面部皮肤表面上的面部纹理的步骤。 在特定实施例中，面部皮肤纹理选自宏观纹理，微纹理及其组合。

公开(公告)号：US20110262025A1

公开(公告)日：2011-10-27

申请号：US13022150

申请日：2011-02-07

Applicant: Bradley Bryan Jarrold ,  Robert Lloyd Binder ,  Michael Keith Robinson ,  Leo Timothy Laughlin, II ,  Karen Marie Lammers

Inventor： Bradley Bryan Jarrold ,  Robert Lloyd Binder ,  Michael Keith Robinson ,  Leo Timothy Laughlin, II ,  Karen Marie Lammers

IPC: A61K31/455 ,  C40B40/06 ,  C40B30/04 ,  G06K9/00 ,  C40B40/10 ,  C07D213/82 ,  A61Q19/00 ,  C40B40/08 ,  C40B30/00

CPC classification number: A61Q19/08 ,  A61K8/606 ,  A61Q19/00 ,  G01N33/5044

Abstract: Gene panels, biomarker panels and microarrays relating to lipid formation in stratum corneum of human skin as a function of extrinsic and/or intrinsic aging conditions, and methods for assessing the age status of human skin, methods for identifying or evaluating an agent as effective for improving stratum corneum barrier maintenance and/or repair properties in aged skin, and cosmetic composition comprising the identified agents are all provided.

Abstract translation: 与人体皮肤角质层中脂质形成相关的基因组，生物标志物组和微阵列作为外在和/或内在老化条件的函数，以及用于评估人皮肤年龄状态的方法，用于鉴定或评价试剂的方法对于 改善老化皮肤中的角质层屏障维持和/或修复性能，以及包含鉴定的试剂的化妆品组合物。

公开(公告)号：US08283135B2

公开(公告)日：2012-10-09

申请号：US11595530

申请日：2006-11-10

Applicant: Matthew Joseph Doyle ,  Leo Timothy Laughlin ,  Todd Laurence Underiner ,  Begonia Y. Ho ,  Rowan Andrew Grayling

Inventor： Matthew Joseph Doyle ,  Leo Timothy Laughlin ,  Todd Laurence Underiner ,  Begonia Y. Ho ,  Rowan Andrew Grayling

IPC: A61K7/16

CPC classification number: A61K8/4946 ,  A61K8/02 ,  A61K8/19 ,  A61K8/21 ,  A61K8/22 ,  A61K8/24 ,  A61K8/25 ,  A61K8/27 ,  A61K8/345 ,  A61K8/347 ,  A61K8/37 ,  A61K8/416 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/4973 ,  A61K8/55 ,  A61K8/60 ,  A61K8/673 ,  A61K8/676 ,  A61K8/678 ,  A61K8/731 ,  A61K8/8164 ,  A61K8/86 ,  A61K8/97 ,  A61K8/9706 ,  A61K31/00 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/662 ,  A61K45/06 ,  A61Q11/00 ,  A61Q17/005

Abstract: The present invention encompasses topical oral care compositions comprising the combination of an anti-bacterial agent with an anti-inflammatory agent in an orally acceptable carrier for effective treatment and prevention of bacteria-mediated diseases and conditions in the oral cavity and for modulating host reaction to bacterial pathogens present in the oral cavity and to the toxins, endotoxins, inflammatory cytokines and mediators released by or prompted by these pathogens. The present invention also encompasses methods of use of these compositions comprising topical application to the oral cavity. The benefits of the present compositions and methods extend beyond treating and preventing oral bacterial infections in the oral cavity to promoting whole body or systemic health.

Abstract translation: 本发明包括在口腔可接受的载体中包含抗细菌剂与抗炎剂的组合的局部口腔护理组合物，用于有效治疗和预防细菌介导的口腔疾病和病症并调节宿主对于 存在于口腔中的细菌病原体和由这些病原体释放或促使的毒素，内毒素，炎性细胞因子和介质。 本发明还包括使用这些组合物的方法，其包括局部施用于口腔。 本发明组合物和方法的益处不仅在口腔内治疗和预防口腔细菌感染以促进全身或全身健康。

公开(公告)号：US20120237460A1

公开(公告)日：2012-09-20

申请号：US13402677

申请日：2012-02-22

Applicant: Cheri Lynn Swanson ,  Leo Timothy Laughlin, II ,  Deborah Ruth Finlay

Inventor： Cheri Lynn Swanson ,  Leo Timothy Laughlin, II ,  Deborah Ruth Finlay

IPC: A61K8/97 ,  A61Q19/02 ,  A61Q19/08 ,  A61Q17/04

CPC classification number: A61Q19/02 ,  A61K8/97 ,  A61K2800/78 ,  A61Q17/00 ,  A61Q19/08

Abstract: A method of improving the appearance of aging skin may comprise the step of applying a composition comprising an effective amount of banyan tree serum fraction, lotus serum fraction, and clover serum fraction to a sign of aging on a skin surface, wherein the composition is applied for a period of time sufficient to improve the appearance of the aging skin. The method may include the step of identifying a sign of aging on a facial skin surface.

Abstract translation: 改善皮肤老化外观的方法可以包括将包含有效量的榕树血清级分，莲藕血清级分和三叶草血清级分的组合物施用到皮肤表面上的老化迹象的步骤，其中施用所述组合物 一段时间足以改善皮肤老化的外观。 该方法可以包括识别面部皮肤表面上的老化迹象的步骤。

公开(公告)号：US20110166370A1

公开(公告)日：2011-07-07

申请号：US13004077

申请日：2011-01-11

Applicant: Charles Winston Saunders ,  Jun Xu ,  Leo Timothy Laughlin, II ,  Zubin Sarosh Khambatta ,  Phillip Richard Green

Inventor： Charles Winston Saunders ,  Jun Xu ,  Leo Timothy Laughlin, II ,  Zubin Sarosh Khambatta ,  Phillip Richard Green

IPC: C07C53/126 ,  C12P7/64 ,  C12N1/00 ,  C12N1/21

CPC classification number: C12P7/6409 ,  C12N9/90 ,  C12N9/93 ,  C12Y504/99002 ,  C12Y604/01003

Abstract: Methods and cells for producing scattered branched-chain fatty acids are provided. For example, the invention provides a method for producing branched-chain fatty acid comprising a methyl on one or more even number carbons. The method comprises culturing a cell comprising an exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA and/or an exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes the conversion of succinyl-CoA to methylmalonyl-CoA, under conditions allowing expression of the polynucleotide(s) and production of branched-chain fatty acid. The cell produces more branched-chain fatty acid comprising a methyl on one or more even number carbons than an otherwise similar cell that does not comprise the polynucleotide(s). A cell that produces branched-chain fatty acid and the branched-chain fatty acid also are provided.

Abstract translation: 提供了生产分散的支链脂肪酸的方法和细胞。 例如，本发明提供一种生产包含一个或多个偶数碳上的甲基的支链脂肪酸的方法。 该方法包括培养包含外源或过表达多核苷酸的细胞，其包含编码催化丙酰CoA转化为甲基丙二酰辅酶A的多肽的核酸序列，和/或外源或过表达的多核苷酸，其包含编码催化的多肽的核酸序列 在允许表达多核苷酸和产生支链脂肪酸的条件下将琥珀酰-CoA转化为甲基丙二酰辅酶A。 与不包含多核苷酸的另外相似的细胞相比，该细胞产生更多的支链脂肪酸，其包含一个或多个偶数碳上的甲基。 还提供了产生支链脂肪酸和支链脂肪酸的细胞。

公开(公告)号：US20110097286A1

公开(公告)日：2011-04-28

申请号：US12841980

申请日：2010-07-22

Applicant: Cheri Lynn Swanson ,  Tomohiro Hakozaki ,  Leo Timothy Laughlin, II

Inventor： Cheri Lynn Swanson ,  Tomohiro Hakozaki ,  Leo Timothy Laughlin, II

IPC: A61K36/03 ,  A61Q17/04 ,  A61K8/96 ,  A61P17/00

CPC classification number: A61K8/975 ,  A61K8/44 ,  A61K8/675 ,  A61K8/9706 ,  A61K31/198 ,  A61K31/445 ,  A61K31/455 ,  A61K36/03 ,  A61K36/06 ,  A61K36/48 ,  A61K36/754 ,  A61K36/899 ,  A61K36/906 ,  A61K45/06 ,  A61Q19/02 ,  A61K2300/00

Abstract: A composition for inhibiting PAR2 activation of keratinocytes is disclosed as comprising a vitamin B3 compound, an N-acyl amino acid compound, and a Laminaria Saccharina extract. In one embodiment, the composition for inhibiting PAR2 activation of keratinocytes comprises niacinamide, N-undecylenoyl-L-phenylalanine, and a Laminaria Saccharina extract. In response to the technical problems identified in the background, the present invention may take other forms including methods for inhibiting PAR2 activation of keratinocytes.

Abstract translation: 公开了一种抑制角质形成细胞PAR2活化的组合物，其包含维生素B3化合物，N-酰基氨基酸化合物和扁桃体提取物。 在一个实施方案中，用于抑制角质形成细胞PAR2活化的组合物包括烟酰胺，N-十一烯酰基-L-苯丙氨酸和Laminaria Saccharina提取物。 响应于背景技术问题，本发明可以采取包括抑制角质形成细胞PAR2活化的方法的其它形式。

公开(公告)号：US06969512B2

公开(公告)日：2005-11-29

申请号：US10268356

申请日：2002-10-10

Applicant: Philip Frederick Brode, III ,  Garry Steven Garrett ,  Leo Timothy Laughlin ,  Randall Stryker Matthews

Inventor： Philip Frederick Brode, III ,  Garry Steven Garrett ,  Leo Timothy Laughlin ,  Randall Stryker Matthews

IPC: A01M1/02 ,  A01M1/20 ,  A01N20060101 ,  A01N25/00 ,  A01N25/02 ,  A01N25/08 ,  A01N31/00 ,  A01N33/02 ,  A01N35/06 ,  A01N37/00 ,  A01N37/06 ,  A01N43/16 ,  A01N43/40 ,  A01N43/54 ,  A01N43/66 ,  A01N61/00 ,  C07H9/06 ,  C07H15/203 ,  A01N43/50 ,  A01N25/34 ,  A01N43/52

CPC classification number: A01M1/026 ,  A01M1/2011 ,  A01M2200/011 ,  A01N25/006 ,  A01N35/06 ,  A01N43/16 ,  A01N61/00 ,  C07H9/06 ,  C07H15/203 ,  Y10S424/11 ,  A01N2300/00

Abstract: This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.

公开(公告)号：US06716421B2

公开(公告)日：2004-04-06

申请号：US09799184

申请日：2001-03-05

Applicant: Philip Frederick Brode, III ,  Garry Steven Garrett ,  Leo Timothy Laughlin ,  Randall Stryker Matthews ,  Dale Edwin Barker ,  Daniel James Kinne ,  Gary Eugene McKibben ,  Christopher Miles Miller ,  Timothy Robert Probst

Inventor： Philip Frederick Brode, III ,  Garry Steven Garrett ,  Leo Timothy Laughlin ,  Randall Stryker Matthews ,  Dale Edwin Barker ,  Daniel James Kinne ,  Gary Eugene McKibben ,  Christopher Miles Miller ,  Timothy Robert Probst

IPC: A01N3100

CPC classification number: A01M1/2011 ,  A01M1/026 ,  A01M2200/011 ,  A01N25/006 ,  A01N35/06 ,  A01N43/16 ,  C07H9/06 ,  C07H15/203 ,  Y10S424/11 ,  A01N2300/00

Abstract: This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.

Abstract translation: 本发明涉及用于消除白蚁菌落的装置，试剂盒和方法。 试剂盒，装置和方法采用灭蚁饵基质，其包含a）选择的杀白蚁剂，使得在白蚁开始摄入杀白蚁剂或诱饵之后约24至约84天内，杀白蚁剂导致约50至约100％的白蚁死亡 包含杀白蚁剂的基质，b）含纤维素材料，和c）水。杀螨诱饵基质可用于安装在地下的诱饵站。 这些套件适合家庭消费者使用。

公开(公告)号：US08673372B2

公开(公告)日：2014-03-18

申请号：US13402608

申请日：2012-02-22

Applicant: Cheri Lynn Swanson ,  Leo Timothy Laughlin, II ,  Deborah Ruth Finlay

Inventor： Cheri Lynn Swanson ,  Leo Timothy Laughlin, II ,  Deborah Ruth Finlay

IPC: A61K36/00 ,  A61K8/00

CPC classification number: A61K8/97 ,  A61K2800/782 ,  A61Q19/02

Abstract: A method of improving the appearance of a hyperpigmented spot may comprise the step of applying a composition comprising an effective amount of banyan tree serum fraction, lotus serum fraction, and clover serum fraction to a hyperpigmented spot on a skin surface, wherein the composition is applied for a period of time sufficient to improve the appearance of the hyperpigmented spot. The method may include the step of identifying a hyperpigmented spot on a facial skin surface. Other methods as disclosed include a method for improving the appearance of post-inflammatory hyperpigmentation.

Abstract translation: 改善色素沉着斑的外观的方法可以包括将包含有效量的榕树血清级分，莲花血清级分和三叶草血清级分的组合物施用于皮肤表面上色素沉着斑点的步骤，其中施用所述组合物 一段时间足以改善色素沉着斑的外观。 该方法可以包括识别面部皮肤表面上色素沉着斑点的步骤。 所公开的其它方法包括改善炎症后色素沉着过度的外观的方法。