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17 条记录 (耗时 0.015 秒)

    Dermal penetration enhancers and drug delivery systems involving same
    3.
    发明授权
    Dermal penetration enhancers and drug delivery systems involving same 有权
    皮肤渗透增强剂和涉及其的药物递送系统

    公开(公告)号：US06299900B1

    公开(公告)日：2001-10-09

    申请号：US09125436

    申请日：1998-12-18

    申请人： Barry Leonard Reed ,  Timothy Matthias Morgan ,  Barrie Charles Finnin

    发明人： Barry Leonard Reed ,  Timothy Matthias Morgan ,  Barrie Charles Finnin

    IPC分类号： A61K910

    CPC分类号： A61Q17/04 ,  A61K8/046 ,  A61K8/37 ,  A61K8/445 ,  A61K9/0014 ,  A61K9/12 ,  A61K9/122 ,  A61K47/14 ,  A61M35/003 ,  Y02A50/411 ,  Y10S514/947 ,  Y10S514/974

    摘要： A transdermal drug delivery system which comprises at least one physiologically active agent or prodrug thereof and at least one dermal penetration enhancer; characterized in that the dermal penetration enhancer is a safe skin-tolerant ester sunscreen. A non-occlusive, percutaneous or transdermal drug delivery system which comprises: (i) an effective amount of at least one physiologically active agent or prodrug thereof; (ii) at least one non-volatile dermal penetration enhancer; and (iii) at least one volatile liquid; characterised in that the dermal penetration enhancer is adapted to transport the physiologically active agent across a dermal surface or mucosal membrane of an animal, including a human, when the volatile liquid evaporates, to form a reservoir or depot of a mixture comprising the penetration enhancer and the physiologically active agent or prodrug within said surface or membrane; and the dermal penetration enhancer is of low toxicity to, and is tolerated by, the dermal surface or mucosal membrane of the animal.

    摘要翻译： 一种透皮药物递送系统，其包含至少一种生理活性剂或其前药和至少一种皮肤渗透促进剂; 其特征在于，皮肤渗透增强剂是安全的耐受皮肤的酯类防晒剂。 非闭塞性，经皮或透皮药物递送系统，其包括：（i）有效量的至少一种生理活性剂或其前药; （ii）至少一种非挥发性皮肤渗透增强剂; 和（iii）至少一种挥发性液体; 其特征在于，当挥发性液体蒸发时，皮肤渗透促进剂适于将生理活性剂输送到包括人的动物的真皮表面或粘膜上，以形成包含渗透增强剂和 所述表面或膜内的生理活性剂或前药; 并且皮肤渗透增强剂对动物的真皮表面或粘膜具有低毒性并且被其耐受。

    Dermal penetration enhancers and drug delivery systems involving same
    6.
    发明授权
    Dermal penetration enhancers and drug delivery systems involving same 有权
    皮肤渗透增强剂和涉及其的药物递送系统

    公开(公告)号：US06818226B2

    公开(公告)日：2004-11-16

    申请号：US09910780

    申请日：2001-07-24

    申请人： Barry Leonard Reed ,  Timothy Matthias Morgan ,  Barrie Charles Finnin

    发明人： Barry Leonard Reed ,  Timothy Matthias Morgan ,  Barrie Charles Finnin

    IPC分类号： A61K970

    CPC分类号： A61Q17/04 ,  A61K8/046 ,  A61K8/37 ,  A61K8/445 ,  A61K9/0014 ,  A61K9/12 ,  A61K9/122 ,  A61K47/14 ,  A61M35/003 ,  Y02A50/411 ,  Y10S514/947 ,  Y10S514/974

    摘要： A transdermal drug delivery system which comprises at least one physiologically active agent or prodrug thereof and at least one dermal penetration enhancer; characterised in that the dermal penetration enhancer is a safe skin-tolerant ester sunscreen. A non-occlusive, percutaneous or transdermal drug delivery system which comprises: (i) an effective amount of at least one physiologically active agent or prodrug thereof; (ii) at least one non-volatile dermal penetration enhancer; and (iii) at least one volatile liquid; characterised in that the dermal penetration enhancer is adapted to transport the physiologically active agent across a dermal surface or mucosal membrane of an animal, including a human, when the volatile liquid evaporates, to form a reservoir or depot of a mixture comprising the penetration enhancer and the physiologically active agent or prodrug within said surface or membrane; and the dermal penetration enhancer is of low toxicity to, and is tolerated by, the dermal surface or mucosal membrane of the animal.

    摘要翻译： 一种透皮药物递送系统，其包含至少一种生理活性剂或其前药和至少一种皮肤渗透促进剂; 其特征在于，所述皮肤渗透增强剂是安全的耐受皮肤的酯类防晒剂。非闭塞性，经皮或透皮药物递送系统，其包括：（i）有效量的至少一种生理活性剂或其前药;（ii） 至少一种非挥发性皮肤渗透增强剂; 和（iii）至少一种挥发性液体;其特征在于，当挥发性液体蒸发时，皮肤渗透增强剂适于将生理活性剂转运到包括人的动物的真皮表面或粘膜上，以形成储存器或 包含渗透促进剂和所述表面或膜内的生理活性剂或前药的混合物的贮存库;以及皮肤渗透增强剂对动物的真皮表面或粘膜具有低毒性并且被其表皮受体耐受。

    Extractor cup on a miniature x-ray tube
    7.
    发明申请
    Extractor cup on a miniature x-ray tube 有权
    抽出杯在微型x射线管上

    公开(公告)号：US20060093091A1

    公开(公告)日：2006-05-04

    申请号：US11291020

    申请日：2005-11-30

    申请人： Paul Lovoi ,  Petre Vatahov ,  Earl Dozier ,  Peter Smith ,  Leonard Reed ,  Robert Neimeyer

    发明人： Paul Lovoi ,  Petre Vatahov ,  Earl Dozier ,  Peter Smith ,  Leonard Reed ,  Robert Neimeyer

    IPC分类号： H05G2/00 ,  G21G4/00 ,  H01J35/00

    CPC分类号： H01J35/06 ,  H01J35/14

    摘要： Methods for connecting electrical potential to an extractor cup at the cathode of a miniature x-ray tube are disclosed. The various connection schemes are designed to form a rugged and conveniently manufacturable connection between the metal extractor cup and one side of the cathode filament, so that the extractor cup shapes the path of electrons as desired en route to the anode of the tube. Some of the disclosed connections involve evaporation of conductive metal or other materials off the filament when the filament is first activated. Others involve applying a paste or paint conductive precursor directly to a base to connect a post and the extractor, the paste being heat-cured after the completion of assembly. Others involve a fine wire or spring strip from one filament post to the walls of the extractor cup. Other schemes include welded or brazed wires or foil, crimping, pinching, swaging and other connections, all made inside the tube enclosure.

    摘要翻译： 公开了将电位连接到微型X射线管的阴极处的抽出杯的方法。 各种连接方案被设计成在金属提取器杯和阴极丝的一侧之间形成坚固且方便可制造的连接，使得提取器杯根据需要在管的阳极途中形成电子的路径。 所公开的一些连接涉及当灯丝首先被激活时将导电金属或其它材料从灯丝上蒸发掉。 其他方面涉及将糊状物或涂料导电性前体直接施加到基底以连接柱和提取器，膏体在组装完成之后被热固化。 其他涉及从一个细丝柱到提取杯的壁的细丝或弹簧条。 其他方案包括焊接或钎焊线或箔，压接，夹紧，模锻和其他连接，全部在管外壳内。

    Extractor cup on a miniature x-ray tube
    10.
    发明授权
    Extractor cup on a miniature x-ray tube 有权

    公开(公告)号：US07130381B2

    公开(公告)日：2006-10-31

    申请号：US11291020

    申请日：2005-11-30

    申请人： Paul A. Lovoi ,  Petre H. Vatahov ,  Earl E. Dozier ,  Peter C. Smith ,  Leonard Reed ,  Robert G. Neimeyer

    发明人： Paul A. Lovoi ,  Petre H. Vatahov ,  Earl E. Dozier ,  Peter C. Smith ,  Leonard Reed ,  Robert G. Neimeyer

    IPC分类号： H01J35/06

    CPC分类号： H01J35/06 ,  H01J35/14

    摘要： Methods for connecting electrical potential to an extractor cup at the cathode of a miniature x-ray tube are disclosed. The various connection schemes are designed to form a rugged and conveniently manufacturable connection between the metal extractor cup and one side of the cathode filament, so that the extractor cup shapes the path of electrons as desired en route to the anode of the tube. Some of the disclosed connections involve evaporation of conductive metal or other materials off the filament when the filament is first activated. Others involve applying a paste or paint conductive precursor directly to a base to connect a post and the extractor, the paste being heat-cured after the completion of assembly. Others involve a fine wire or spring strip from one filament post to the walls of the extractor cup. Other schemes include welded or brazed wires or foil, crimping, pinching, swaging and other connections, all made inside the tube enclosure.