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公开(公告)号：US09655772B2
公开(公告)日：2017-05-23
申请号：US13525817
申请日：2012-06-18
申请人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
发明人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
CPC分类号： A61F7/12 , A61B2018/00875 , A61F7/007 , A61F2007/0005 , A61F2007/0075 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/0296 , A61N1/36036 , A61N2/002 , A61N2/006
摘要： An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.
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2.发明申请公开(公告)号：US20120310313A1
公开(公告)日：2012-12-06
申请号：US13584853
申请日：2012-08-14
申请人： Lesco L. Rogers , Jesko von Windheim , Seri Lee
发明人： Lesco L. Rogers , Jesko von Windheim , Seri Lee
IPC分类号： A61N1/36
CPC分类号： A61F7/007 , A61F2007/0075 , F25B21/02 , F25B2321/021 , H01L35/32
摘要： A temperature control system may include a thermoelectric device, a controller electrically coupled to the thermoelectric device, a heat transfer structure thermally coupled to the thermoelectric device, a temperature controlled medium thermally coupled to the thermoelectric device and a temperature feedback sensor. The controller may be configured to sense a first value of an electrical characteristic of the thermoelectric device and to generate a first electrical control to activate the thermoelectric device in response to sensing the first value of the electrical characteristic of the thermoelectric device. The controller may be further configured to sense a second value of the electrical characteristic of the thermoelectric device and to generate a second electrical control signal to activate the thermoelectric device in response to sensing the second value of the electrical characteristic of the thermoelectric device.
摘要翻译： 温度控制系统可以包括热电装置，电耦合到热电装置的控制器，热耦合到热电装置的热传递结构，热耦合到热电装置的温度控制介质和温度反馈传感器。 控制器可以被配置为感测热电装置的电特性的第一值，并且响应于感测热电装置的电特性的第一值而产生第一电控制以激活热电装置。 控制器还可以被配置成感测热电装置的电特性的第二值，并且响应于感测热电装置的电特性的第二值而产生第二电控制信号以激活热电装置。
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公开(公告)号：US08267983B2
公开(公告)日：2012-09-18
申请号：US12693016
申请日：2010-01-25
申请人： Lesco L. Rogers , Jesko von Windheim , Seri Lee
发明人： Lesco L. Rogers , Jesko von Windheim , Seri Lee
IPC分类号： A61F7/12
CPC分类号： F25B21/02 , A61F7/007 , A61F2007/0075 , F25B2321/021 , H01L35/32
摘要： A temperature control system may include a thermoelectric device, a controller electrically coupled to the thermoelectric device, a heat transfer structure thermally coupled to the thermoelectric device, and a temperature controlled medium thermally coupled to the thermoelectric device. The controller may be configured to sense a first value of an electrical characteristic of the thermoelectric device and to generate a first electrical control signal to pump heat through the thermoelectric device in response to sensing the first value of the electrical characteristic of the thermoelectric device. The controller may be further configured to sense a second value of the electrical characteristic of the thermoelectric device and to generate a second electrical control signal to pump heat through the thermoelectric device in response to sensing the second value of the electrical characteristic of the thermoelectric device.
摘要翻译： 温度控制系统可以包括热电装置，电耦合到热电装置的控制器，热耦合到热电装置的热传递结构，以及热耦合到热电装置的温度控制介质。 控制器可以被配置为响应于感测热电装置的电特性的第一值而感测热电装置的电特性的第一值并且产生第一电控制信号以便通过热电装置泵送热量。 控制器还可以被配置为响应于感测热电装置的电特性的第二值而感测热电装置的电特性的第二值并且产生第二电控制信号以便通过热电装置泵送热量。
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公开(公告)号：US09861519B2
公开(公告)日：2018-01-09
申请号：US13990622
申请日：2011-12-16
申请人： Lesco L. Rogers , Lanty L. Smith , Robert D. Black
发明人： Lesco L. Rogers , Lanty L. Smith , Robert D. Black
CPC分类号： A61F7/12 , A61B2018/00875 , A61F7/007 , A61F2007/0005 , A61F2007/0075 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/0296 , A61N1/36036 , A61N2/002 , A61N2/006
摘要： A device for delivering caloric vestibular stimulation to an individual, includes: (a) an earpiece configured to be at least partially insertable into the ear canal of the individual for delivering a first thermal stimulus; (b) an input unit for receiving a user input indicating efficacy of said first thermal stimulus, and (c) a controller operatively associated with said earpiece and said input unit for: (i) controlling said earpiece to provide said first thermal stimulus, and (ii) receiving a signal corresponding to the user input and generating a control signal to control the earpiece and delivering a subsequent thermal stimulus different from said first thermal stimulus. In some embodiments, each thermal stimulus is an actively controlled time varying waveform stimulus.
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5.发明授权公开(公告)号：US09283111B2
公开(公告)日：2016-03-15
申请号：US13994266
申请日：2011-12-16
申请人： Lesco L. Rogers , Lanty L. Smith , Robert D. Black
发明人： Lesco L. Rogers , Lanty L. Smith , Robert D. Black
CPC分类号： A61F7/12 , A61B2018/00875 , A61F7/007 , A61F2007/0005 , A61F2007/0075 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/0296 , A61N1/36036 , A61N2/002 , A61N2/006
摘要： An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.
摘要翻译： 用于对受试者的耳道施加热量刺激的入耳式刺激装置包括：（a）构造成可插入到对象的耳道中的第一和第二耳机; （b）至少第一和第二热电装置热耦合到第一和第二耳机中的相应的一个; （c）热耦合到与第一耳机相对的第一热电装置的第一散热器和与第二耳机相对的与第二热电装置热耦合的第二散热器; 和（d）包括与第一和第二热电装置连通的波形发生器的控制器，所述波形发生器被配置为产生第一控制信号以控制到第一热电装置的第一热量输出和第二控制信号以控制第二热电装置 热量输出到第二热量装置。
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6.发明申请公开(公告)号：US20120316624A1
公开(公告)日：2012-12-13
申请号：US13525765
申请日：2012-06-18
申请人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
发明人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61B2018/00875 , A61F7/007 , A61F2007/0005 , A61F2007/0075 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/0296 , A61N1/36036 , A61N2/002 , A61N2/006
摘要： An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.
摘要翻译： 用于对受试者的耳道施加热量刺激的入耳式刺激装置包括：（a）构造成可插入到对象的耳道中的第一和第二耳机; （b）至少第一和第二热电装置热耦合到第一和第二耳机中的相应的一个; （c）热耦合到与第一耳机相对的第一热电装置的第一散热器和与第二耳机相对的与第二热电装置热耦合的第二散热器; 和（d）包括与第一和第二热电装置连通的波形发生器的控制器，所述波形发生器被配置为产生第一控制信号以控制到第一热电装置的第一热量输出和第二控制信号以控制第二热电装置 热量输出到第二热量装置。
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公开(公告)号：US08262717B2
公开(公告)日：2012-09-11
申请号：US12669684
申请日：2008-08-01
申请人： Lesco L. Rogers , Lanty L. Smith
发明人： Lesco L. Rogers , Lanty L. Smith
IPC分类号： A61F7/12
CPC分类号： A61H39/06 , A61B5/01 , A61F7/00 , A61F7/007 , A61F7/12 , A61F2007/0005 , A61F2007/0075 , A61H2201/165 , A61H2201/5082 , A61H2205/027 , A61N1/36036 , A61N1/403 , B33Y80/00
摘要： A device and associated method for providing vestibular stimulation to an individual includes active elements positioned on or proximate an ear insert. The active elements include but are not limited to at least one electrode, at least one thermometer, and at least one thermoelectric transducer. The device includes a computerized control module regulating the active elements. The device incorporates an ear insert that allows the active elements to engage the individual's ear canal and therefore access the individual's vestibular system. Vestibular stimulation applied to the individual is customized for directly stimulating desired regions of the brain for therapeutic or diagnostic purposes. In a preferred embodiment, the device provides vestibular stimulation sufficient to promote physiological changes in the individual, the changes selected from the group consisting of circadian temperature cycle time shifts, ascorbic acid production, serotonin production, acetylcholine production, histamine production, and heat shock protein production.
摘要翻译： 用于向个体提供前庭刺激的装置和相关联的方法包括定位在耳塞上或附近的有源元件。 有源元件包括但不限于至少一个电极，至少一个温度计和至少一个热电换能器。 该装置包括调节有源元件的计算机控制模块。 该装置包括耳塞，其允许有源元件接合个人的耳道，并且因此访问个人的前庭系统。 应用于个体的前庭刺激被定制用于直接刺激脑的所需区域用于治疗或诊断目的。 在优选的实施方案中，该装置提供足以促进个体的生理变化的前庭刺激，所述变化选自昼夜温度循环时间变化，抗坏血酸产生，5-羟色胺产生，乙酰胆碱生成，组胺产生和热休克蛋白 生产。
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公开(公告)号：US10390991B2
公开(公告)日：2019-08-27
申请号：US13584853
申请日：2012-08-14
申请人： Lesco L. Rogers , Jesko von Windheim , Seri Lee
发明人： Lesco L. Rogers , Jesko von Windheim , Seri Lee
摘要： A temperature control system may include a thermoelectric device, a controller electrically coupled to the thermoelectric device, a heat transfer structure thermally coupled to the thermoelectric device, a temperature controlled medium thermally coupled to the thermoelectric device and a temperature feedback sensor. The controller may be configured to sense a first value of an electrical characteristic of the thermoelectric device and to generate a first electrical control to activate the thermoelectric device in response to sensing the first value of the electrical characteristic of the thermoelectric device. The controller may be further configured to sense a second value of the electrical characteristic of the thermoelectric device and to generate a second electrical control signal to activate the thermoelectric device in response to sensing the second value of the electrical characteristic of the thermoelectric device.
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公开(公告)号：US09168171B2
公开(公告)日：2015-10-27
申请号：US13990912
申请日：2011-12-16
申请人： Lesco L. Rogers
发明人： Lesco L. Rogers
CPC分类号： A61F7/12 , A61F7/007 , A61F2007/0005 , A61F2007/0075 , A61F2007/0093 , A61F2007/0096
摘要： A method of treating a subject in need thereof, is carried out by (a) administering said subject a therapeutic intervention (e.g., an active agent) in a treatment effective amount; and concurrently (b) administering said subject caloric vestibular stimulation in a treatment effective amount, said caloric vestibular stimulation administered so as to enhance the efficacy of said active agent. In some embodiments, the caloric vestibular stimulation is administered as an actively controlled time varying waveform.
摘要翻译： 通过（a）以治疗有效量向所述受试者施用治疗性干预（例如活性剂）进行治疗有此需要的受试者的方法; 并且（b）以治疗有效量施用所述受试者热量前庭刺激，施用所述热量前庭刺激以提高所述活性剂的功效。 在一些实施例中，热量前庭刺激作为主动控制的时变波形来施用。
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公开(公告)号：US09168170B2
公开(公告)日：2015-10-27
申请号：US13525765
申请日：2012-06-18
申请人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
发明人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
摘要： An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.
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