公开(公告)号：US08436015B2

公开(公告)日：2013-05-07

申请号：US13063820

申请日：2009-09-10

Applicant: Songnian Lin ,  Christian P. Stevenson ,  Emma R. Parmee ,  Libo Xu ,  Xibin Liao ,  Edward Metzger ,  Rui Liang ,  Fengqi Zhang ,  John E. Stelmach

Inventor： Songnian Lin ,  Christian P. Stevenson ,  Emma R. Parmee ,  Libo Xu ,  Xibin Liao ,  Edward Metzger ,  Rui Liang ,  Fengqi Zhang ,  John E. Stelmach

IPC: A01N43/42 ,  A61K31/47 ,  C07D215/00

CPC classification number: C07D215/18 ,  C07D215/227 ,  C07D217/22 ,  C07D217/24 ,  C07D239/70 ,  C07D403/04 ,  C07D413/04

Abstract: Glucagon receptor antagonist compounds of formula I are disclosed: The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

Abstract translation: 公开了式I的胰高血糖素受体拮抗剂化合物：该化合物可用于治疗2型糖尿病和相关病症。 还包括药物组合物和治疗方法。

公开(公告)号：US08318667B2

公开(公告)日：2012-11-27

申请号：US13202124

申请日：2010-02-15

Applicant: Songnian Lin ,  Libo Xu ,  Edward Metzger ,  Emma R. Parmee ,  Sheryl D. Debenham

Inventor： Songnian Lin ,  Libo Xu ,  Edward Metzger ,  Emma R. Parmee ,  Sheryl D. Debenham

IPC: A61K38/26 ,  A61P3/10 ,  C07K14/605

CPC classification number: C07D231/56

Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type (2) diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

Abstract translation: 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗（2）型糖尿病和相关病症。 还包括药物组合物和治疗方法。

公开(公告)号：US20150336991A1

公开(公告)日：2015-11-26

申请号：US14652883

申请日：2013-12-12

Applicant: Emma R. PARMEE ,  Songnian LIN ,  Brian CAMPBELL ,  Sunita V. DEWNANI ,  Roman KATS-KAGAN ,  Jiayi XU ,  Libo XU ,  Rui ZHANG ,  MERCK SHARP & DOHME CORP.

Inventor： Songnian Lin ,  Rui Zhang ,  Brian Campbell ,  Sunita V. Dewnani ,  Jiayi Xu ,  Libo Xu ,  Emma R. Parmee ,  Roman Kats-Kagan

IPC: C07F9/6539 ,  A61K31/4439 ,  C07D401/04 ,  A61K31/444 ,  C07D471/04 ,  A61K31/427 ,  C07F9/58 ,  A61K31/675 ,  C07D403/14 ,  A61K31/497 ,  C07D417/14 ,  C07D401/14 ,  A61K31/437

CPC classification number: C07F9/6539 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/675 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07F7/0812 ,  C07F9/58 ,  C07F9/65583

Abstract: Novel pyridine-2-carboxamide derivatives of formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included.

Abstract translation: 公开了式I的新型吡啶-2-甲酰胺衍生物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。 这些化合物作为葡萄糖激酶活化剂是有效的。 还包括药物组合物和治疗方法。

公开(公告)号：US6008321A

公开(公告)日：1999-12-28

申请号：US39837

申请日：1998-03-16

Applicant: Ge Li ,  Sian Louise Griffiths ,  Edward McDonald ,  Libo Xu

Inventor： Ge Li ,  Sian Louise Griffiths ,  Edward McDonald ,  Libo Xu

IPC: C07B61/00 ,  C07C317/44 ,  C07C323/52 ,  G01N33/543 ,  C07C59/48 ,  C07C59/56 ,  C07C233/00 ,  G01N33/545

CPC classification number: C07C323/52 ,  C07C317/44 ,  C40B40/00 ,  Y02P20/55

Abstract: A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## wherein t is 0 or 1; n is 3-20; R is OH, an activated ester or the residue of a solid support having a plurality of amino functionalities; A is --O-- or --NH-- and Q is hydrogen or a protecting group for an amine or alcohol.

公开(公告)号：US20110172256A1

公开(公告)日：2011-07-14

申请号：US13063820

申请日：2009-09-10

Applicant: Songnian Lin ,  Christian P. Stevenson ,  Emma R. Parmee ,  Libo Xu ,  Xibin Liao ,  Edward metzger ,  Rui Liang ,  Fengqi Zhang ,  John E. Stelmach

Inventor： Songnian Lin ,  Christian P. Stevenson ,  Emma R. Parmee ,  Libo Xu ,  Xibin Liao ,  Edward metzger ,  Rui Liang ,  Fengqi Zhang ,  John E. Stelmach

IPC: A61K31/517 ,  C07D215/14 ,  A61K31/47 ,  A61P3/10 ,  C07D215/227 ,  C07D471/04 ,  A61K31/4375 ,  C07D239/74

CPC classification number: C07D215/18 ,  C07D215/227 ,  C07D217/22 ,  C07D217/24 ,  C07D239/70 ,  C07D403/04 ,  C07D413/04

Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

公开(公告)号：US6093799A

公开(公告)日：2000-07-25

申请号：US421732

申请日：1999-10-20

Applicant: Ge Li ,  Sian Louise Griffiths ,  Edward McDonald ,  Libo Xu

Inventor： Ge Li ,  Sian Louise Griffiths ,  Edward McDonald ,  Libo Xu

IPC: C07B61/00 ,  C07C317/44 ,  C07C323/52 ,  G01N33/543 ,  C07C59/48 ,  C07C59/56 ,  C07C231/00 ,  G01N33/545

CPC classification number: C07C323/52 ,  C07C317/44 ,  C40B40/00 ,  Y02P20/55

Abstract: A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## wherein t is 0 or 1; n is 3-20; R is OH, an activated ester or the residue of a solid support having a plurality of amino functionalities; A is --O-- or --NH-- and Q is hydrogen or a protecting group for an amine or alcohol.

Abstract translation: 公开了用于固相合成的底物。 还公开了制备基材和其中有用的中间体的方法。 其中新型中间体是下式的化合物：其中t为0或1; n为3-20; R是OH，活化酯或具有多个氨基官能团的固体支持物的残基; A是-O-或-NH-，Q是氢或胺或醇的保护基。

公开(公告)号：US20160250184A1

公开(公告)日：2016-09-01

申请号：US15030779

申请日：2014-10-30

Applicant: Songnian LIN ,  Libo XU ,  Emma R. PARMEE ,  Xibin LIAO ,  MERCK SHARP & DOHME CORP.

Inventor： SONGNIAN LIN ,  Libo Xu ,  Emma R. Parmee ,  Xibin Liao

IPC: A61K31/404 ,  A61K45/06 ,  A61K31/397 ,  C07D209/20

CPC classification number: A61K31/404 ,  A61K31/397 ,  A61K31/4035 ,  A61K45/06 ,  C07D209/18 ,  C07D209/20 ,  A61K2300/00

Abstract: Glucagon receptor antagonist compounds are disclosed which are of long duration of action. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

Abstract translation: 披露了长时间作用的胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。

公开(公告)号：US20080132500A1

公开(公告)日：2008-06-05

申请号：US11975537

申请日：2007-10-19

Applicant: Kun Liu ,  Peter T. Meinke ,  James F. Dropinski ,  Libo Xu

Inventor： Kun Liu ,  Peter T. Meinke ,  James F. Dropinski ,  Libo Xu

IPC: A61K31/4365 ,  C07D419/14 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/497 ,  A61P31/04

CPC classification number: C07D515/22

Abstract: Certain water-soluble thiazolyl peptides are antibiotic capable of treating serious bacterial infections in mammals, and particularly, in humans. Some of the analogs can also be employed as versatile intermediates for the preparation of new derivatives with useful antibacterial activity.

Abstract translation: 某些水溶性噻唑基肽是能够治疗哺乳动物，特别是人类的严重细菌感染的抗生素。 一些类似物也可以用作制备具有有用抗菌活性的新衍生物的通用中间体。

公开(公告)号：US06569879B2

公开(公告)日：2003-05-27

申请号：US09932834

申请日：2001-08-17

Applicant: Kun Liu ,  Libo Xu ,  A. Brian Jones

Inventor： Kun Liu ,  Libo Xu ,  A. Brian Jones

IPC: A61K3142

CPC classification number: C07D261/20 ,  A61K31/00 ,  A61K45/06

Abstract: A class of aryloxyacetic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.