公开(公告)号：US20060025460A1

公开(公告)日：2006-02-02

申请号：US11156364

申请日：2005-06-17

申请人： Alfredo Castro ,  Wei Deng ,  Kristopher Depew ,  Michael Foley ,  Christian Fritz ,  Asimina Georges Evangelinos ,  Michael Grogan ,  Nafeeza Hafeez ,  Edward Holson ,  Brian Hopkins ,  Nii Koney ,  Tao Liu ,  David Mann ,  Lisa Marcaurelle ,  Daniel Snyder ,  Dennis Underwood ,  Andrew Wylie ,  Lin-Chen Yu ,  Linping Zhang

发明人： Alfredo Castro ,  Wei Deng ,  Kristopher Depew ,  Michael Foley ,  Christian Fritz ,  Asimina Georges Evangelinos ,  Michael Grogan ,  Nafeeza Hafeez ,  Edward Holson ,  Brian Hopkins ,  Nii Koney ,  Tao Liu ,  David Mann ,  Lisa Marcaurelle ,  Daniel Snyder ,  Dennis Underwood ,  Andrew Wylie ,  Lin-Chen Yu ,  Linping Zhang

IPC分类号： C07D261/02 ,  A61K31/42

CPC分类号： C07D261/02 ,  C07D261/18 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04

摘要： One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.