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    Essential bacterial genes and their use
    2.
    发明授权
    Essential bacterial genes and their use 失效
    基本细菌基因及其用途

    公开(公告)号：US06749858B2

    公开(公告)日：2004-06-15

    申请号：US10190279

    申请日：2002-07-05

    Applicant: Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

    Inventor： Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

    IPC: A61K39085

    CPC classification number: C07K14/32 ,  C07K14/245 ,  C07K14/3156

    Abstract: Disclosed are two genes, termed “yphC” and “yqjK,” found in Streptococcus pneumoniae, which are essential for survival for a wide range of bacteria. These genes and the essential polypeptides that they encode, as well as homologs and orthologs thereof, can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

    Abstract translation: 公开了在肺炎链球菌中发现的两种称为“yphC”和“yqjK”的基因，其对于广泛的细菌的存活是必需的。 这些基因及其编码的必需多肽以及其同系物和直系同源物可用于鉴定用于治疗广谱细菌感染的抗菌剂。

    Essential bacterial genes and their use
    3.
    发明授权
    Essential bacterial genes and their use 失效
    基本细菌基因及其用途

    公开(公告)号：US06437108B1

    公开(公告)日：2002-08-20

    申请号：US09222938

    申请日：1998-12-30

    Applicant: Philip Youngman ,  Christian Fritz ,  Christopher Murphy ,  Luz-Maria Guzman

    Inventor： Philip Youngman ,  Christian Fritz ,  Christopher Murphy ,  Luz-Maria Guzman

    IPC: C07H2102

    CPC classification number: C07K14/3156 ,  C07K14/32

    Abstract: Disclosed are 23 genes, termed “GEP” genes, found in Streptococcus pneumonia, which are located within operons that are essential for survival. Also disclosed is a related essential gene found in Bacillus subtilis. These genes and the polypeptides that they encode, as well as homologs thereof, can be used to identify antibacterial agents for treating bacterial infections such as streptococcal pneumonia.

    Abstract translation: 公开了在链球菌肺炎中发现的23个基因，称为“GEP”基因，其位于操纵子内对生存至关重要。 还公开了在枯草芽孢杆菌中发现的相关必需基因。 这些基因及其编码的多肽及其同源物可用于鉴定用于治疗细菌感染如链球菌肺炎的抗菌剂。

    Use of ylqF, yqeG, yybQ, and ysxC, essential bacterial genes and polypeptides
    5.
    发明授权
    Use of ylqF, yqeG, yybQ, and ysxC, essential bacterial genes and polypeptides 失效
    使用ylqF，yqeG，yybQ和ysxC，必需的细菌基因和多肽

    公开(公告)号：US07329508B2

    公开(公告)日：2008-02-12

    申请号：US11436271

    申请日：2006-05-17

    Applicant: Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

    Inventor： Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

    IPC: C12Q1/18

    CPC classification number: G01N33/56944 ,  C12Q1/18 ,  G01N2333/315 ,  G01N2500/04

    Abstract: Disclosed are genes found in Streptococcus pneumoniae that are essential for survival for a wide range of bacteria. These genes are termed “S-ylqF,” “S-yqeG,” “S-yybQ,” “S-yerL,” and “S-ysxC.” These genes and the polypeptides that they encode, as well as homologs and orthologs thereof can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

    Abstract translation: 公开了在肺炎链球菌中发现的对广泛细菌生存至关重要的基因。 这些基因被称为“S-ylqF”，“S-yqeG”，“S-yybQ”，“S-yerL”和“S-ysxC”。 它们编码的这些基因及其多肽，以及其同系物和直系同源物可用于鉴定用于治疗广谱细菌感染的抗菌剂。

    Use of S-ydcB and B-ydcB, essential bacterial genes
    7.
    发明授权
    Use of S-ydcB and B-ydcB, essential bacterial genes 失效
    使用S-ydcB和B-ydcB，必需的细菌基因

    公开(公告)号：US06515119B1

    公开(公告)日：2003-02-04

    申请号：US09163446

    申请日：1998-09-30

    Applicant: Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

    Inventor： Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

    IPC: C07H2102

    CPC classification number: C12Q1/18 ,  A61K38/00 ,  C07K14/315 ,  G01N33/9446

    Abstract: Disclosed are methods for using the essential genes and polypeptides “S-ydcB,” found in Streptococcus pneumoniae, and “B-ydcB,” found in Bacillus subtilis. These genes and polypeptides, as well as homologs and orthologs thereof, can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

    Abstract translation: 公开了使用在嗜肺链球菌中发现的必需基因和多肽“S-ydcB”的方法和在枯草芽孢杆菌中发现的“B-ydcB”的方法。 这些基因和多肽以及同系物和直系同源物可用于鉴定用于治疗广谱细菌感染的抗菌剂。

    Use of YNES, essential bacterial genes and polypeptides
    8.
    发明授权
    Use of YNES, essential bacterial genes and polypeptides 失效
    使用YNES，必需细菌基因和多肽

    公开(公告)号：US06472377B1

    公开(公告)日：2002-10-29

    申请号：US09163445

    申请日：1998-09-30

    Applicant: Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

    Inventor： Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

    IPC: A61K3170

    CPC classification number: C07K14/3156 ,  A61K38/00 ,  C07K14/315 ,  C07K14/32 ,  C12Q1/18 ,  G01N33/9446

    Abstract: Disclosed is a gene, termed “S-yneS,” found in Streptococcus pneumoniae, which is essential for survival for a wide range of bacteria. This gene and the S-yneS polypeptide that it encodes, as well as homologs and orthologs thereof (collectively referred to as “yneS” genes and polypeptides) can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

    Abstract translation: 公开了在肺炎链球菌中发现的称为“S-yneS”的基因，其对于广泛的细菌的存活是必需的。 该基因及其编码的S-yneS多肽，以及其同系物和直系同源物（统称为“yneS”基因和多肽）可用于鉴定用于治疗广谱细菌感染的抗菌剂。

    Game set beast-of-prey hunt
    9.
    发明授权
    Game set beast-of-prey hunt 有权
    游戏设置野兽猎物

    公开(公告)号：US06293549B1

    公开(公告)日：2001-09-25

    申请号：US09342078

    申请日：1999-06-28

    Applicant: Stephan Peter ,  Christian Fritz

    Inventor： Stephan Peter ,  Christian Fritz

    IPC: A63F302

    CPC classification number: A63F3/00145 ,  A63F2003/00186

    Abstract: A set for a hunting-a-beast-prey game including two square boards each having twenty-five playing fields and four additional playing fields provided outside of the square defining the twenty-five playing fields, and two times twenty-nine playing figures consisting of twenty-five figures representing hunters, and four figures representing beasts of prey.

    Abstract translation: 一组狩猎野兽猎物游戏，包括两个方块板，每个都有二十五个运动场和四个额外的运动场，在定义二十五个运动场的广场之外提供，另外两个二十九个玩家组成 二十五位数字代表猎人，四位数字代表猎物。

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