公开(公告)号：US10047116B2

公开(公告)日：2018-08-14

申请号：US14349142

申请日：2012-10-01

申请人： MX Adjuvac AB

发明人： Bror Morein ,  Saideh Berenjian ,  Kafei Hu

IPC分类号： A61K39/00 ,  C07J9/00 ,  A61K31/255 ,  A61K31/337 ,  A61K31/52 ,  A61K31/593 ,  A61K31/704 ,  A61K31/7068 ,  A61K39/145 ,  A61K39/39 ,  A61K36/73 ,  C12Q1/48 ,  G01N33/50 ,  A61K9/51 ,  A61K39/12

CPC分类号： C07J9/00 ,  A61K9/5123 ,  A61K31/255 ,  A61K31/337 ,  A61K31/52 ,  A61K31/593 ,  A61K31/704 ,  A61K31/7068 ,  A61K36/73 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/55555 ,  A61K2039/55577 ,  A61K2300/00 ,  C12N2760/16134 ,  C12N2760/16234 ,  C12Q1/485 ,  G01N33/5011 ,  G01N2800/52 ,  Y10T428/2982

摘要： The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja saponin, which nanoparticles do not comprise a phospholipid. It also relates to a composition comprising the nanoparticles, and the use thereof as adjuvant, especially in vaccines, as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nanoparticles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.

公开(公告)号：US20180327443A1

公开(公告)日：2018-11-15

申请号：US15815488

申请日：2017-11-16

申请人： MX Adjuvac AB

发明人： Bror Morein ,  Saideh Berenjian ,  Kafei Hu

IPC分类号： C07J9/00 ,  G01N33/50 ,  A61K9/51 ,  A61K31/255 ,  A61K31/337 ,  A61K31/52 ,  A61K31/593 ,  A61K31/704 ,  A61K31/7068 ,  C12Q1/48 ,  A61K39/39 ,  A61K39/145 ,  A61K39/12 ,  A61K36/73 ,  A61K39/00

CPC分类号： C07J9/00 ,  A61K9/5123 ,  A61K31/255 ,  A61K31/337 ,  A61K31/52 ,  A61K31/593 ,  A61K31/704 ,  A61K31/7068 ,  A61K36/73 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/55555 ,  A61K2039/55577 ,  A61K2300/00 ,  C12N2760/16134 ,  C12N2760/16234 ,  C12Q1/485 ,  G01N33/5011 ,  G01N2800/52 ,  Y10T428/2982

摘要： The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja saponin, which nanoparticles do not comprise a phospholipid. It also relates to a composition comprising the nanoparticles, and the use thereof as adjuvant, especially in vaccines, as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nanoparticles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.

公开(公告)号：US10100078B2

公开(公告)日：2018-10-16

申请号：US15605595

申请日：2017-05-25

申请人： MX Adjuvac AB

发明人： Bror Morein ,  Saideh Berenjian ,  Kafei Hu

IPC分类号： G01N33/536 ,  C07J9/00 ,  A61K31/255 ,  A61K31/337 ,  A61K31/52 ,  A61K31/593 ,  A61K31/704 ,  A61K31/7068 ,  A61K39/145 ,  A61K39/39 ,  A61K36/73 ,  C12Q1/48 ,  G01N33/50 ,  A61K9/51 ,  A61K39/12 ,  A61K39/00

摘要： The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja saponin, which nanoparticles do not comprise a phospholipid. It also relates to a composition comprising the nanoparticles, and the use thereof as adjuvant, especially in vaccines, as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nano particles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.