公开(公告)号：US20130131322A1

公开(公告)日：2013-05-23

申请号：US13698420

申请日：2011-05-17

申请人： Makoto Kaneda ,  Yoshihiro Fujii ,  Yoshihiro Hayata ,  Yoshiro Kishi ,  Ichiro Yahara

发明人： Makoto Kaneda ,  Yoshihiro Fujii ,  Yoshihiro Hayata ,  Yoshiro Kishi ,  Ichiro Yahara

IPC分类号： C07K16/22 ,  C07K14/495

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K14/495 ,  C07K2317/24 ,  C07K2317/76

摘要： It has been found out that among antibodies showing reactivity with wild type TGF-α, antibodies less reactive with G79A-substituted TGF-α have an excellent growth-suppressing effect on cancer cells having a mutated Ras gene. Further, it has been found out that most of these antibodies have an activity of inhibiting EGFR tyrosine phosphorylation and/or an induction-suppressing activity on vascular endothelial cells.

摘要翻译： 已经发现，在显示与野生型TGF-α的反应性的抗体中，与G79A取代的TGF-α较少反应的抗体对具有突变的Ras基因的癌细胞具有优异的生长抑制作用。 此外，已经发现大多数这些抗体具有抑制EGFR酪氨酸磷酸化和/或对血管内皮细胞的诱导抑制活性的活性。

公开(公告)号：US06416329B1

公开(公告)日：2002-07-09

申请号：US09634500

申请日：2000-08-08

申请人： Kashichi Hirota ,  Makoto Kaneda

发明人： Kashichi Hirota ,  Makoto Kaneda

IPC分类号： B43L100

CPC分类号： B43L1/008

摘要： In a magnetically writable and erasable writing device for practice in writing characters, the writing device includes a case member provided with an opening in a top surface of the case member wherein a frame section surrounding the opening is formed on the top surface of the case member. A writing sheet includes a microcapsule magnetic sheet and is disposed on the case member so as to expose a top face of the writing sheet from the opening of the case member. A magnetic member for writing on the writing sheet and an erasing member which is positioned under the writing sheet and which has magnetism is included in the case member. The magnetic member put on the top face of the writing sheet enables writing and moving the erasing member along a back face of the writing sheet enables the written contents to be erased. The frame section of the top surface of the case member indicates a character model.

摘要翻译： 在用于书写字符练习的磁性可写和可擦写的书写装置中，书写装置包括壳体构件，壳体构件在壳体构件的顶表面中设置有开口，其中围绕开口的框架部分形成在壳体构件的顶表面上 。 书写用纸包括微胶囊磁性薄片，并且设置在所述外壳构件上，以使所述书写用纸的顶面从所述外壳构件的开口露出。 用于写在书写用纸上的磁性构件和位于书写板下方并且具有磁性的擦除构件包括在壳体构件中。 放置在书写纸的顶面上的磁性部件使得能够沿着书写纸的背面书写和移动擦除部件使得写入的内容能够被擦除。 壳体构件的上表面的框架部分表示字符模型。

公开(公告)号：US6102557A

公开(公告)日：2000-08-15

申请号：US39648

申请日：1998-03-16

申请人： Makoto Kaneda

发明人： Makoto Kaneda

IPC分类号： F21S8/10 ,  F21V7/00 ,  F21V7/09 ,  B60Q1/00

CPC分类号： F21S48/137 ,  F21S48/1388

摘要： A headlamp wherein an auxiliary reflector is arranged at at least one of portions close to above, left or right ends of a main reflector providing an effective section of a reflecting mirror and outside a range that forms a light distribution characteristic. The auxiliary reflector reflects a light in a direction adjacent to a side opposite to a side at which the auxiliary reflector is arranged relative to the light distribution characteristic defined by the main reflector. The novel constitution allows a headlamp of this type, in which a light having a relatively large tilt angle from the optical axis has been conventionally prevented by the housing of the headlamp from being radiated, to effectively radiate such a light in a desired direction and in a necessary range.

摘要翻译： 一种前照灯，其中辅助反射器被布置在主反射器的靠近上方的左右两端的部分中的至少一个处，从而提供反射镜的有效部分，并且在形成光分布特性的范围之外。 辅助反射器相对于由主反射器限定的光分布特性反射与辅助反射器的配置侧相反的一侧的方向上的光。 新颖的构造允许这种类型的前照灯通常通过前照灯的外壳被辐射来防止来自光轴的具有相对较大倾斜角的光，以有效地将光照射在期望的方向上 必要范围。

公开(公告)号：US06315573B1

公开(公告)日：2001-11-13

申请号：US09634254

申请日：2000-08-07

申请人： Kashichi Hirota ,  Makoto Kaneda

发明人： Kashichi Hirota ,  Makoto Kaneda

IPC分类号： B43L100

CPC分类号： B43L1/008 ,  B43L3/005

摘要： A table or base for a telephone or the like includes an outer case, a recording sheet which is retractable within the outer case and which includes a microcapsule magnetic sheet, and an erasing magnetic member disposed within the outer case. The outer case has a top surface on which the telephone and other articles can be placed. The erasing magnetic member is positioned under the recording sheet when the inner case is pushed into the outer case. Thus, pulling out the recording sheet from the outer case enables a top face of the recording sheet to be magnetically written in, and pushing the recording sheet into the outer case enables the magnetic writing on the recording sheet to be erased.

摘要翻译： 用于电话等的桌子或底座包括外壳，在外壳内可缩回并且包括微胶囊磁片的记录片，以及设置在外壳内的擦除磁性构件。 外壳具有可以放置电话和其他物品的顶表面。 当内壳被推入外壳时，擦除磁性构件位于记录纸的下方。 因此，从外壳拉出记录纸可以使记录纸的顶面被磁性地写入，并且将记录纸推入外壳使得能够擦除记录纸上的磁写。

公开(公告)号：US5214551A

公开(公告)日：1993-05-25

申请号：US938587

申请日：1992-09-02

申请人： Makoto Kaneda

发明人： Makoto Kaneda

IPC分类号： G11B15/093 ,  G11B15/18 ,  G11B15/44

CPC分类号： G11B15/093 ,  G11B15/1883 ,  G11B15/442

摘要： A driving device of a tape recorder in which a sliding plate supporting a magnetic head and a pinch roller is arranged for movement relative to a base and the sliding plate is adapted to be driven to an operating position where the pinch roller comes into a cooperating condition with a capstan at a record-play operation. The driving device includes a cam to drive the sliding plate and such cam, at an initial period of the record-play operation, is driven by a predetermined angle in a predetermined direction to engage the sliding plate, thereby causing the sliding plate to move to the operating position. The driving device is provided with a driven gear continuously driven by a motor and a partially toothed gear which frictionally engages the driven gear to thereby drive the cam.

摘要翻译： PCT No.PCT / JP88 / 01012 Sec。 371日期1990年2月7日 102（e）日期1990年2月7日PCT提交1988年10月4日PCT公布。 WO90 / 04250 PCT出版物 日期：1990年04月19日。一种磁带录像机的驱动装置，其中支撑磁头和夹送辊的滑板布置成相对于基座运动，并且滑板适于被驱动到操作位置，其中， 夹紧辊与记录播放操作中的绞盘进行合作。 驱动装置包括用于驱动滑板的凸轮，并且在记录播放操作的初始阶段，这种凸轮沿预定方向被驱动预定角度以接合滑板，从而使滑板移动到 的操作位置。 该驱动装置设置有由马达连续驱动的从动齿轮和与从动齿轮摩擦接合从而驱动凸轮的部分齿轮。

公开(公告)号：US06450401B1

公开(公告)日：2002-09-17

申请号：US09634854

申请日：2000-08-08

申请人： Kashichi Hirota ,  Makoto Kaneda

发明人： Kashichi Hirota ,  Makoto Kaneda

IPC分类号： G06K1906

CPC分类号： B43L1/008

摘要： A writing board with an electronic calculator and a writing board to which an electronic calculator is installable. The writing board including a case member provided with an opening in a top surface of the case member, and a frame section surrounding the opening is formed on the top surface of the case member. A recording sheet including a microcapsule magnetic sheet is disposed in the case member with a top face of the recording sheet exposed through the opening of the case member. A magnetic member is used for writing on the recording sheet. The writing board further includes a magnetized erasing sheet which is positioned under the recording sheet in parallel with the recording sheet. An erasing button is used in the case member so that writings on the recording sheet can be erased only by depressing the erasing button. An electronic calculator is or can be mounted on the top surface of the case member.

摘要翻译： 具有可安装电子计算器的电子计算器和书写板的书写板。 所述书写板包括壳体构件，所述壳体构件在所述壳体构件的顶表面中设置有开口，并且在所述壳体构件的顶表面上形成围绕所述开口的框架部。 包括微胶囊磁性片的记录片材设置在盒构件中，记录片材的顶面通过壳体构件的开口露出。 磁性构件用于在记录纸上书写。 书写板还包括与记录片材平行地定位在记录片材下方的磁化擦除片材。 在外壳构件中使用擦除按钮，使得只能通过按下擦除按钮来擦除记录纸上的写入。 电子计算器可以或可以安装在壳体构件的顶表面上。

公开(公告)号：US08980257B2

公开(公告)日：2015-03-17

申请号：US13698420

申请日：2011-05-17

申请人： Makoto Kaneda ,  Yoshihiro Fujii ,  Yoshihiro Hayata ,  Yoshiro Kishi ,  Ichiro Yahara

发明人： Makoto Kaneda ,  Yoshihiro Fujii ,  Yoshihiro Hayata ,  Yoshiro Kishi ,  Ichiro Yahara

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K16/24 ,  C12N15/00 ,  C12N15/09 ,  C12N15/11 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  C12N5/16 ,  C12N5/18 ,  C12N5/20 ,  C12N5/22 ,  C12N5/24 ,  C12N5/26 ,  C12N5/28 ,  C07K16/22 ,  C07K14/495

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K14/495 ,  C07K2317/24 ,  C07K2317/76

摘要： It has been found out that among antibodies showing reactivity with wild type TGF-α, antibodies less reactive with G79A-substituted TGF-α have an excellent growth-suppressing effect on cancer cells having a mutated Ras gene. Further, it has been found out that most of these antibodies have an activity of inhibiting EGFR tyrosine phosphorylation and/or an induction-suppressing activity on vascular endothelial cells.

摘要翻译： 已经发现，在显示与野生型TGF-α的反应性的抗体中，与G79A取代的TGF-α反应性较差的抗体对具有突变的Ras基因的癌细胞具有优异的生长抑制作用。 此外，已经发现大多数这些抗体具有抑制EGFR酪氨酸磷酸化和/或对血管内皮细胞的诱导抑制活性的活性。

公开(公告)号：US06427928B1

公开(公告)日：2002-08-06

申请号：US09656424

申请日：2000-09-06

申请人： Kashichi Hirota ,  Makoto Kaneda

发明人： Kashichi Hirota ,  Makoto Kaneda

IPC分类号： A47G2118

CPC分类号： B65D77/283

摘要： A straw comprises a cylindrical plug member having an opening at a top thereof, and a straw member which vertically extends through a bottom portion of the plug member and which is retractable in the longitudinal direction of the straw member, wherein the straw is adapted to fit the plug member with a top of a mouth of a beverage container so as to retain in a state where the straw is inserted into the beverage container. The straw is also adapted to allow a top of the straw member to be protruded from the mouth of the beverage container by extending the straw member and to allow the top of the straw member to be contained within the plug member by retracting the straw member so as to attach a cap of the beverage container.

摘要翻译： 秸秆包括在其顶部具有开口的圆柱形塞构件和垂直延伸穿过插塞构件的底部并且可沿着秸秆构件的纵向收缩的吸管构件，其中吸管适于配合 所述塞子构件具有饮料容器的口部的顶部，以便在所述吸管插入所述饮料容器中的状态下保持。 吸管还适于通过延伸吸管构件使秸秆构件的顶部从饮料容器的口部突出，并且通过缩回吸管构件使得吸管构件的顶部被收纳在插塞构件内 以便连接饮料容器的盖子。

公开(公告)号：US06375019B1

公开(公告)日：2002-04-23

申请号：US09761723

申请日：2001-01-18

申请人： Kashichi Hirota ,  Makoto Kaneda

发明人： Kashichi Hirota ,  Makoto Kaneda

IPC分类号： B65D3900

CPC分类号： B65D77/283

摘要： A straw including a straw member having an outer straw portion and an inner straw portion, the outer and inner straw portions being telescopingly fitted with each other, the inner straw portion including an elastic upper section, and a cylindrical plug member having an opening at the upper end thereof. The inner straw portion is retained in the state inserted into a beverage container by mounting the plug member to the upper end of a mouth of the beverage container, and the upper section of the inner straw portion is bent by pressing with a beverage container cap so as to attach the beverage container cap to the beverage container, and the upper end of the inner straw portion is protruded from the upper end of the plug member by detaching the beverage container cap.

摘要翻译： 一种秸秆，包括具有外吸管部分和内吸管部分的吸管部件，所述外吸管部分和内吸管部分彼此可伸缩地配合，所述内吸管部分包括弹性上部部分，以及在所述吸管部分处具有开口 其上端。 通过将插塞部件安装到饮料容器的口部的上端部，将内部吸收部分保持在插入饮料容器的状态，并且内部吸收部分的上部通过与饮料容器盖部压制而弯曲 为了将饮料容器盖附接到饮料容器，并且通过分离饮料容器盖，内吸管部分的上端从插塞构件的上端突出。

公开(公告)号：US4026496A

公开(公告)日：1977-05-31

申请号：US598380

申请日：1975-07-23

申请人： Makoto Kaneda

发明人： Makoto Kaneda

IPC分类号： G11B15/10 ,  G11B15/44

CPC分类号： G11B15/10 ,  Y10T74/20244

摘要： An automatic repeat system for magnetic tape recorders and reproducers is disclosed which is provided with an automatic repeat mechanism adapted to set the magnetic tape to its reproducing or rewinding status in response to the resetting of the reproducing lever or rewinding lever to be effected by means of an automatic stop mechanism serving the purpose of resetting the reproducing lever or rewinding lever upon termination of the reproducing or rewinding motion.

摘要翻译： 公开了一种用于磁带录音机和再现器的自动重复系统，其具有自动重复机构，该自动重复机构适于将磁带设置为其再现或重绕状态，以响应于通过重放杆或倒带杆的复位 一种自动停止机构，用于在再现或重绕动作终止时复位再现杆或倒带杆。