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    TARGETED CELLULAR SELECTIVITY OF SURFACE ACTIVE MOLECULES
    1.
    发明申请
    TARGETED CELLULAR SELECTIVITY OF SURFACE ACTIVE MOLECULES 审中-公开
    表面活性分子的目标细胞选择性

    公开(公告)号：US20110020228A1

    公开(公告)日：2011-01-27

    申请号：US12865589

    申请日：2009-02-02

    申请人： Brij M. Moudgil ,  Manoj Varshney ,  Stephen R. Grobmyer

    发明人： Brij M. Moudgil ,  Manoj Varshney ,  Stephen R. Grobmyer

    IPC分类号： A61K49/00 ,  A61K31/765 ,  A61K31/20 ,  A61K31/201 ,  A61K31/23 ,  A61K31/231 ,  A61K36/47 ,  A61K36/889 ,  A61K36/899 ,  A61K31/341 ,  A61K31/08 ,  A61K31/355 ,  A61K31/7024 ,  A61K31/05 ,  A61K31/575 ,  A61K31/221 ,  A61K31/255 ,  A61P35/00

    CPC分类号： A61K49/0017 ,  A61K31/765 ,  A61K47/543 ,  A61K47/60

    摘要： A method for the treatment of cancer involves delivering a surface active agent to an organism, where the surface active agent selectively partitions to and kills cancer cells as opposed to healthy cells. The surface active agent can be an ionic or a non-ionic surfactant with a HLB of less than 29 or a mixture of surface active agents with a HLB of less than 40, where the hydrophobic portion is a lesser fraction of the surface active agent than the hydrophilic portion. A fluorescence method of detecting and locating cancer cells in an organism involves delivering a surface active agent, where the surface active agent includes a fluorescence moiety that upon selective partitioning of the surface active agent to the cancer cells and irradiation by a radiation source to excite the fluorescence moiety, a fluorescence emission is observed permitting the detection and location of the cancerous tissue by local volumes of relatively high intensity emission.

    摘要翻译： 用于治疗癌症的方法涉及将表面活性剂递送到生物体，其中与健康细胞相反，表面活性剂选择性地分隔并杀死癌细胞。 表面活性剂可以是HLB小于29的离子或非离子表面活性剂或HLB小于40的表面活性剂的混合物，其中疏水部分是表面活性剂的较少部分， 亲水部分。 检测和定位生物体内的癌细胞的荧光方法包括递送表面活性剂，其中表面活性剂包括荧光部分，当将表面活性剂选择性分配到癌细胞时，通过辐射源照射以激发 观察到荧光发射，允许通过相当高强度发射的局部体积检测和定位癌组织。

    Neem oil microemulsion without cosurfactants or alcohols and a process to form the same
    2.
    发明授权
    Neem oil microemulsion without cosurfactants or alcohols and a process to form the same 失效
    没有辅助表面活性剂或醇的楝树油微乳液和形成它们的方法

    公开(公告)号：US06703034B2

    公开(公告)日：2004-03-09

    申请号：US10016243

    申请日：2001-12-10

    申请人： Balraj S. Parmar ,  Manoj Varshney ,  Dinesh O. Shah

    发明人： Balraj S. Parmar ,  Manoj Varshney ,  Dinesh O. Shah

    IPC分类号： A01N2504

    CPC分类号： B01F17/0028 ,  B01F17/0085 ,  Y10S514/938

    摘要： A method of forming an oil in water microemulsion includes the steps of providing at least one non-ionic ethoxylated surfactant, providing an oil and mixing the surfactant and the oil to form a microemulsion. The surfactant can be selected from the group of alkyl phenol ethoxylates, where the alkyl group contains 8 to 12 carbons and the ethoxylate contains an average of 4 to 12 ethoxylate groups. The surfactant can be a nonyl phenol ethoxylate. An oil in water microemulsion includes at least one non-ionic ethoxylated surfactant and at least one oil. The surfactant can be a single surfactant or a mixed surfactant. The oil can be derived from at least one tree, preferably from as the Neem Tree.

    摘要翻译： 在水微乳液中形成油的方法包括提供至少一种非离子乙氧基化表面活性剂，提供油并混合表面活性剂和油形成微乳液的步骤。 表面活性剂可以选自烷基酚乙氧基化物，其中烷基含有8至12个碳，乙氧基化物平均含有4至12个乙氧基化物基团。 表面活性剂可以是壬基苯酚乙氧基化物。 水包油微乳液包括至少一种非离子乙氧基化表面活性剂和至少一种油。 表面活性剂可以是单一表面活性剂或混合表面活性剂。 油可以衍生自至少一棵树，最好从Neem Tree得到。

    Micelles and Nanoemulsions for Preventive and Reactive Treatment of Atherosclerosis
    7.
    发明申请
    Micelles and Nanoemulsions for Preventive and Reactive Treatment of Atherosclerosis 审中-公开
    胶束和纳米乳剂用于动脉粥样硬化的预防和反应性治疗

    公开(公告)号：US20080311207A1

    公开(公告)日：2008-12-18

    申请号：US11662157

    申请日：2005-09-08

    申请人： Manoj Varshney ,  Dinesh O. Shah

    发明人： Manoj Varshney ,  Dinesh O. Shah

    IPC分类号： A61K9/14

    CPC分类号： A61K9/1075

    摘要： The subject invention is directed to microemulsion-based (ME) nanoparticles and methods of using same. The ME nanoparticles of the subject invention encompass self-assemblies of oil in water emulsions in the presence of at least two emulsifiers. One of the emulsifiers is a salt of a fatty acid, and the combined concentration of the at least two emulsifiers is sufficiently large to produce micelles, wherein the oil droplets are the hydrophobic core of the micelles. The subject invention also contemplates methods of modifying lipids, high density lipoprotein (HDL), and low density lipoprotein (LDL) in blood by contacting the blood with the ME nanoparticles of the subject invention. Another aspect concerns methods for treating atherosclerosis by administering the ME nanoparticles of the subject invention to a patient in need thereof.

    摘要翻译： 本发明涉及基于微乳液的（ME）纳米颗粒及其使用方法。 本发明的ME纳米颗粒包括在至少两种乳化剂存在下的水包油乳液的自组装。 乳化剂之一是脂肪酸的盐，并且至少两种乳化剂的组合浓度足够大以产生胶束，其中油滴是胶束的疏水核心。 本发明还考虑通过使血液与本发明的ME纳米颗粒接触来改变血液中脂质，高密度脂蛋白（HDL）和低密度脂蛋白（LDL）的方法。 另一方面涉及通过将本发明的ME纳米颗粒给予有需要的患者来治疗动脉粥样硬化的方法。