公开(公告)号：US20070276138A1

公开(公告)日：2007-11-29

申请号：US11637223

申请日：2006-12-11

申请人： Dawn Brooks ,  Alan Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne Reifel-Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Martin ,  Maria Gonzales Garcia ,  Alicia Torrado ,  Rafael Crespo ,  Carlos Lamas-Peteira ,  Robert Ardecky ,  Maria Finger

发明人： Dawn Brooks ,  Alan Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne Reifel-Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Martin ,  Maria Gonzales Garcia ,  Alicia Torrado ,  Rafael Crespo ,  Carlos Lamas-Peteira ,  Robert Ardecky ,  Maria Finger

IPC分类号： C07D265/30 ,  C07C233/87 ,  C07D207/02 ,  C07D209/04 ,  C07D209/32 ,  C07D211/40 ,  C07D277/62 ,  C07D307/87 ,  C07D317/06 ,  C07D333/76 ,  C07D333/08 ,  C07D333/02 ,  C07D317/70 ,  C07D311/30 ,  C07D307/02 ,  C07D215/20 ,  C07D217/02 ,  C07D233/02 ,  C07D241/04 ,  C07D257/04

CPC分类号： C07D209/48 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C217/20 ,  C07C217/84 ,  C07C217/92 ,  C07C219/10 ,  C07C233/25 ,  C07C233/29 ,  C07C233/60 ,  C07C233/75 ,  C07C235/56 ,  C07C235/64 ,  C07C239/12 ,  C07C255/54 ,  C07C2601/08 ,  C07D209/08 ,  C07D213/30 ,  C07D215/14 ,  C07D217/02 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D257/04 ,  C07D277/64 ,  C07D295/096 ,  C07D295/112 ,  C07D295/185 ,  C07D307/79 ,  C07D307/83 ,  C07D307/91 ,  C07D307/93 ,  C07D311/30 ,  C07D317/20 ,  C07D317/22 ,  C07D317/54 ,  C07D317/64 ,  C07D333/16 ,  C07D333/76 ,  C07D335/02

摘要： Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W. R1 is —(CH2)n—CH(OR2)—(CH2)mE, —(CH)═C(OR2)—(CH2)mE, —(CH2)n—CH(Y)—(CH2)mE or —(CH)═C(Y)—(CH2)mE; wherein E is COOR3, C1-C3-alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is —H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or —C(S)NR5R6. R3 is —H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is —O—, —CH2—, —CH2CH2— or —CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.