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公开(公告)号：US20120123119A1
公开(公告)日：2012-05-17
申请号：US13355231
申请日：2012-01-20
IPC分类号： C07D473/18
CPC分类号： C07D473/00 , C07D473/18 , Y02P20/55
摘要： Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3—C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H.
摘要翻译： 用于制备和处理下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，R 1和R 2中的另一个是-C（O）C 3 -C 21饱和或 单不饱和，任选取代的烷基和R 3是OH或H.
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2.发明申请INDENTIFICATION OF COMPOUNDS THAT INHIBIT REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS 审中-公开抑制人类免疫缺陷病毒复制化合物的鉴定公开(公告)号：US20090170953A1
公开(公告)日：2009-07-02
申请号：US11929695
申请日：2007-10-30
IPC分类号： A61K31/164 , C12N7/04 , A61P31/18
CPC分类号： C07C237/06 , A61K31/164 , B01D15/34 , B01D15/362
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
摘要翻译： 本发明涉及发现抑制人类免疫缺陷病毒（HIV）复制的新一类化合物以及鉴定这些化合物的方法。 更具体地，已经发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺抑制人血清中HIV的复制。 实施方案包括鉴定修饰的抑制HIV的甘氨酰胺化合物的方法，分离和合成修饰的甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
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公开(公告)号：US08124609B2
公开(公告)日：2012-02-28
申请号：US12245553
申请日：2008-10-03
IPC分类号： A61K31/522
CPC分类号： C07D473/00 , C07D473/18 , Y02P20/55
摘要： Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H.
摘要翻译： 用于制备和处理下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，R 1和R 2中的另一个是-C（O）C 3 -C 21饱和或 单不饱和，任选取代的烷基和R 3是OH或H.
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公开(公告)号：US07432274B2
公开(公告)日：2008-10-07
申请号：US10741615
申请日：2003-12-19
IPC分类号： A61K31/522 , C07D473/00
CPC分类号： C07D473/00 , C07D473/18
摘要： Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H.
摘要翻译： 用于制备和使用下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，而另一个 R 1和R 2的饱和或单不饱和的C（O）C 3 -C 21 - 任选取代的烷基，R 3是OH或H.
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公开(公告)号：US20070270487A1
公开(公告)日：2007-11-22
申请号：US11749856
申请日：2007-05-17
申请人： Martin Hedberg , Marita Hogberg , Weimin Tong
发明人： Martin Hedberg , Marita Hogberg , Weimin Tong
IPC分类号： A61K31/165 , A61K31/325 , A61K31/137
CPC分类号： C07C255/41 , C07C209/48 , C07C215/28 , C07C231/06 , C07C233/73 , C07C253/30 , C07C271/16
摘要： The present invention relates to a novel process suitable for large-scale production of phenyl propane derivatives as well as to novel intermediates in the process.
摘要翻译： 本发明涉及一种适用于大规模生产苯基丙烷衍生物的新方法以及该方法中的新型中间体。
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公开(公告)号：US07148243B2
公开(公告)日：2006-12-12
申请号：US10243118
申请日：2002-09-12
申请人： Christer Sahlberg , Rolf Noreen , Marita Hogberg , Per Engelhardt
发明人： Christer Sahlberg , Rolf Noreen , Marita Hogberg , Per Engelhardt
IPC分类号： A61K31/44 , C07D213/84
CPC分类号： C07D213/75 , C07D213/85 , Y02P20/55
摘要： Compounds of the formula I: wherein Rx is cyano or bromo; R1 is halo; R2 is C114 C3 alkyl, and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals.
摘要翻译： 式I化合物：其中R x是氰基或溴; R 1是卤素; R 2是C 1 -C 14烷基，其药学上可接受的盐和前药具有作为抗逆转录病毒药物的活性。
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公开(公告)号：US20060183748A1
公开(公告)日：2006-08-17
申请号：US11410633
申请日：2006-04-25
IPC分类号： A61K31/513 , A61K31/4965 , A61K31/495
CPC分类号： A61K31/164 , A61K31/495 , A61K31/4965 , A61K31/513 , A61K31/53 , C07C237/06
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
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8.发明申请Identification of compounds that inhibit replication of human immunodeficiency virus 审中-公开鉴定抑制人类免疫缺陷病毒复制的化合物公开(公告)号：US20060188920A1
公开(公告)日：2006-08-24
申请号：US11409671
申请日：2006-04-24
CPC分类号： C07C237/06 , A61K31/164 , B01D15/34 , B01D15/362
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
摘要翻译： 本发明涉及发现抑制人类免疫缺陷病毒（HIV）复制的新一类化合物以及鉴定这些化合物的方法。 更具体地，已经发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺抑制人血清中HIV的复制。 实施方案包括鉴定修饰的抑制HIV的甘氨酰胺化合物的方法，分离和合成修饰的甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
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公开(公告)号：US20090076041A1
公开(公告)日：2009-03-19
申请号：US12245553
申请日：2008-10-03
IPC分类号： A61K31/522 , A61P31/18 , A61P31/12
CPC分类号： C07D473/00 , C07D473/18 , Y02P20/55
摘要： Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H.
摘要翻译： 用于制备和处理下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，R 1和R 2中的另一个是-C（O）C 3 -C 21饱和或 单不饱和，任选取代的烷基和R 3是OH或H.
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10.发明申请Identification of compounds that inhibit replication of human immunodeficiency virus 审中-公开鉴定抑制人类免疫缺陷病毒复制的化合物公开(公告)号：US20050096319A1
公开(公告)日：2005-05-05
申请号：US10920831
申请日：2004-08-18
申请人： Jan Balzarini , Anders Vahlne , Marita Hogberg , Weimin Tong
发明人： Jan Balzarini , Anders Vahlne , Marita Hogberg , Weimin Tong
IPC分类号： A61K31/164 , C07C237/06 , C07C409/40 , A61K31/53 , A61K31/445 , A61K31/495 , A61K31/513
CPC分类号： A61K31/164 , A61K31/495 , A61K31/4965 , A61K31/513 , A61K31/53 , C07C237/06
摘要： The present invention relates to the discovery of a novel class of compounds that inhibit the replication of human immunodeficiency virus (HIV) and approaches to identify these compounds. More specifically, it has been found that enzymatically prepared alpha-hydroxyglycinamide and synthetically prepared alpha-hydroxyglycinamide inhibit the replication of HIV in human serum. Embodiments include methods to identify modified glycinamide compounds that inhibit HIV, methods to isolate and synthesize modified glycinamide compounds, and therapeutic compositions comprising these compounds.
摘要翻译： 本发明涉及发现抑制人类免疫缺陷病毒（HIV）复制的新一类化合物以及鉴定这些化合物的方法。 更具体地，已经发现酶制备的α-羟基甘氨酰胺和合成制备的α-羟基甘氨酰胺抑制人血清中HIV的复制。 实施方案包括鉴定修饰的抑制HIV的甘氨酰胺化合物的方法，分离和合成修饰的甘氨酰胺化合物的方法，以及包含这些化合物的治疗组合物。
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