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公开(公告)号：US07537590B2
公开(公告)日：2009-05-26
申请号：US11194157
申请日：2005-08-01
IPC分类号： A61K9/22
CPC分类号： A61K9/703 , A61F2013/00642 , A61K9/0009 , A61K9/0021 , A61K9/0097 , A61K9/7084 , A61K9/7092 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.
摘要翻译： 提供了用于向有需要的患者透皮施用药剂的装置和方法。 该装置包括衬底，衬底中的多个分立贮存器，储存在储存器中的一个或多个药剂，防止药剂从储存器中流出直到期望的离散贮存器盖，用于致动释放一个 或更多的药剂从一个或多个储存器中分解或渗透储存器盖，用于将装置固定到患者皮肤的装置，以及用于在药物释放之后将药剂运送到皮肤的装置 水库 在另一个实施方案中，该装置适用于代替药物递送或除药物递送之外的诊断感测。
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公开(公告)号：US06887669B1
公开(公告)日：2005-05-03
申请号：US09542445
申请日：2000-04-04
IPC分类号： G01N33/53 , G01N33/58 , G01N33/94 , G01N1/00 , G01N1/18 , G01N33/531 , G01N33/561
CPC分类号： G01N33/9493 , G01N33/53 , G01N33/5306 , G01N33/94 , Y10S435/961 , Y10S435/962 , Y10S436/825 , Y10T436/25 , Y10T436/25375
摘要： The present invention relates to a method for releasing a ligand from a complex of the ligand with an endogenous protein using a releasing agent.
摘要翻译： 本发明涉及使用脱模剂从配体与内源蛋白质的配合物中释放配体的方法。
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公开(公告)号：US06171801B2
公开(公告)日：2001-01-09
申请号：US08896244
申请日：1997-07-17
IPC分类号： G01N3353
CPC分类号： G01N33/9493 , G01N33/53 , G01N33/5306 , G01N33/94 , Y10S435/961 , Y10S435/962 , Y10S436/825 , Y10T436/25 , Y10T436/25375
摘要： One aspect of the present invention relates to a method for releasing a ligand from a complex thereof. The method comprises contacting a medium suspected of containing such complex with an effective amount of a compound effective in releasing the ligand. Another aspect of the present invention is an improvement in a method for the determination of an analyte that is a member of a specific binding pair in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a compound of the invention in an amount sufficient to enhance the accuracy of the determination. The invention has particular application to a method for releasing mycophenolic acid from a complex thereof. The method provides an improvement in a method for the determination of mycophenolic acid in a sample suspected of containing mycophenolic acid. The present invention also provides assay reagents as well as packaged kits useful for performing the methods of the invention.
摘要翻译： 本发明的一个方面涉及从其络合物中释放配体的方法。 该方法包括将怀疑含有此类复合物的培养基与有效释放配体有效量的化合物接触。 本发明的另一方面是在怀疑含有这些分析物的样品中测定作为特异性结合对成员的分析物的方法的改进。 该方法包括以下步骤：（a）在测定介质中提供样品和分析物的结合配偶体，和（b）检测结合配偶体与分析物的结合。 改进包括在测定培养基中包含足以提高测定精度的本发明化合物。 本发明特别适用于从其复合物中释放霉酚酸的方法。 该方法提供了在怀疑含有霉酚酸的样品中测定霉酚酸的方法的改进。 本发明还提供测定试剂以及用于实施本发明方法的包装试剂盒。
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公开(公告)号：US6159698A
公开(公告)日：2000-12-12
申请号：US895856
申请日：1997-07-17
IPC分类号： G01N33/53 , G01N33/564 , G01N33/94 , G01N1/00 , G01N33/531 , G01N33/543
CPC分类号： G01N33/9493 , G01N33/5306 , G01N33/94 , Y10S435/961 , Y10S435/975 , Y10S436/825 , Y10T436/25
摘要： One aspect of the present invention relates to assays for the detection of mycophenolic acid. The method comprises including in an assay medium suspected of containing mycophenolic acid a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. Another aspect of the present invention is an improvement in a method for the determination of mycophenolic acid in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in combination in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. The present invention also provides assay reagents as well as packaged kits useful for performing the methods of the invention.
摘要翻译： 本发明的一个方面涉及检测霉酚酸的测定法。 该方法包括在疑似含有霉酚酸的测定介质中包含用于从内源蛋白质与复合物释放霉酚酸的释放剂。 本发明的另一方面是在怀疑含有这些分析物的样品中测定霉酚酸的方法的改进。 该方法包括以下步骤：（a）在测定介质中组合提供样品和分析物的结合配偶体，和（b）检测结合配偶体与分析物的结合。 该改进包括在测定培养基中包括用于从与内源蛋白质的复合物中释放霉酚酸的释放剂。 本发明还提供测定试剂以及用于实施本发明方法的包装试剂盒。
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5.发明申请公开(公告)号：US20070275035A1
公开(公告)日：2007-11-29
申请号：US11753330
申请日：2007-05-24
CPC分类号： A61K9/0097 , A61K9/0024 , A61M31/002
摘要： Implantable medical devices and methods of use are provided for controlled drug delivery. The devices may include an elongated body dimensioned to facilitate minimally invasive and complete implantation into a patient, wherein the elongated body portion comprises a first, closed end portion, a second closed end portion and an intermediate portion disposed between and connected to the first closed end portion and the second closed end portion; two or more discrete reservoirs disposed in the elongated body portion, each reservoir having one or more openings; a drug formulation, which comprises at least one drug, disposed in the two more discrete reservoirs; and reservoir caps closing off the one or more openings of each reservoir, wherein release of the drug in vivo is controlled at least in part by the in vivo disintegration or permeabilization of the discrete reservoir caps.
摘要翻译： 为可控制的药物输送提供可植入的医疗装置和使用方法。 所述装置可以包括细长的主体，其尺寸适于促进对患者的微创和完全植入，其中所述细长主体部分包括第一封闭端部，第二封闭端部和设置在所述第一闭合端之间并连接到所述第一闭合端 部分和第二封闭端部; 设置在细长主体部分中的两个或更多个离散储存器，每个储存器具有一个或多个开口; 一种药物制剂，其包含设置在两个更离散的储存器中的至少一种药物; 并且储存器盖封闭每个储存器的一个或多个开口，其中药物在体内的释放至少部分地通过离散储器盖的体内分解或透化来控制。
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6.发明授权Protein purification on immobilized metal affinity resins effected by elution using a weak ligand 失效蛋白质纯化对弱化配体的溶解影响的固定金属亲和性树脂
公开(公告)号：US5169936A
公开(公告)日：1992-12-08
申请号：US338991
申请日：1989-04-14
IPC分类号： C07K14/00 , B01D15/38 , C07K1/00 , C07K1/20 , C07K1/22 , C07K14/42 , C07K14/52 , C07K14/555 , C07K14/575 , C07K14/58 , C07K14/61 , C07K14/65 , C07K14/705 , C07K14/73 , C07K14/76 , C07K16/00
CPC分类号： B01D15/3828 , C07K1/22 , C07K14/70514
摘要： A process for the purification of proteins from solutions containing contaminants of similar net charge and molecular weight is provided, comprising contacting a solution containing the desired protein with an immobilized metal affinity chromatography resin in a buffer containing a low concentration of a weak ligand for the chelant of the resin. The adsorbed protein is then eluted using a buffer having a high concentration of the same weak ligand, e.g., Tris. Particularly preferred features employ agarose-iminodiacetic acid resins having copper cations and are especially useful in obtaining preparations of homogeneous, stable rsT4 proteins.
摘要翻译： 提供了一种从含有类似净电荷和分子量的污染物的溶液中提纯蛋白质的方法，包括将含有所需蛋白质的溶液与固定的金属亲和层析树脂在含有低浓度的弱配体螯合剂的缓冲液 的树脂。 然后使用具有高浓度相同弱配体例如Tris的缓冲液洗脱吸附的蛋白质。 特别优选的特征是使用具有铜阳离子的琼脂二亚氨基二乙酸树脂，并且特别可用于获得均匀稳定的rsT4蛋白质的制备。
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7.发明申请Solid drug formulation and device for storage and controlled delivery thereof 审中-公开固体药物制剂及其储存和控制递送装置公开(公告)号：US20100119604A1
公开(公告)日：2010-05-13
申请号：US12612828
申请日：2009-11-05
IPC分类号： A61K9/00
CPC分类号： A61K9/0097 , A61K9/0009 , A61K9/0024 , A61K38/09
摘要： Devices and methods are provided for the storage and controlled release of a solid form of a drug. The device comprises a body portion; one or more reservoirs located in and defined by the body portion; a solid matrix which comprises a drug and which is contained in each of the one or more reservoirs; and one or more excipient materials dispersed throughout pores or interstices within the solid matrix and substantially filling any space not otherwise occupied by the solid matrix within each of the one or more reservoirs, wherein the excipient material enhances stability of the drug while stored in the one or more reservoirs or enhances release of the drug from each reservoir. In an alternative embodiment, the device provides for the storage and controlled exposure of a chemical sensor material.
摘要翻译： 提供了用于药物的固体形式的储存和控制释放的装置和方法。 该装置包括主体部分; 一个或多个储存器，位于主体部分中并由主体部分限定; 固体基质，其包含药物并且包含在所述一个或多个储存器中的每一个中; 以及分散在固体基质内的整个孔或间隙中的一种或多种赋形剂材料，并且基本上填充一个或多个储存器内的每一个中不另外占据固体基质的任何空间，其中赋形剂材料增强药物的稳定性，同时储存在一个 或更多的储存器或增强药物从每个储存器的释放。 在替代实施例中，该装置提供化学传感器材料的存储和受控曝光。
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公开(公告)号：US20090234214A1
公开(公告)日：2009-09-17
申请号：US12471973
申请日：2009-05-26
IPC分类号： A61B5/145
CPC分类号： A61K9/703 , A61F2013/00642 , A61K9/0009 , A61K9/0021 , A61K9/0097 , A61K9/7084 , A61K9/7092 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： Devices and methods are provided for transdermal diagnostic sensing, alone or in combination with transdermal drug delivery. The device includes a substrate having a plurality of discrete reservoirs, each reservoir having at least one opening; contents disposed in the reservoirs, the contents of each reservoir including a diagnostic agent or a sensor for measuring an analyte; at least one discrete reservoir cap which cover said at least one opening; control means for disintegrating or permeabilizing the reservoir cap; means for transporting an analyte from the skin to said sensors and/or for transporting said diagnostic agent to the skin following release of said diagnostic agents from said reservoir; and means for securing the device to the skin of a patient.
摘要翻译： 提供了用于透皮诊断感测的装置和方法，单独或与透皮药物递送组合。 该装置包括具有多个分立储存器的基板，每个储存器具有至少一个开口; 设置在储存器中的内容物，每个储存器的内容物包括用于测量分析物的诊断剂或传感器; 至少一个分开的储存器盖，其覆盖所述至少一个开口; 用于使储存器盖分解或渗透的控制装置; 用于将分析物从皮肤运送到所述传感器和/或用于在从所述储存器释放所述诊断剂之后将所述诊断剂运输到皮肤的装置; 以及用于将装置固定到患者皮肤的装置。
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公开(公告)号：US5187107A
公开(公告)日：1993-02-16
申请号：US722034
申请日：1991-06-27
申请人： Michael I. Watkins , Clifford R. Bartlett , Edward T. Liang , John M. Pocekay , Mark A. Staples
发明人： Michael I. Watkins , Clifford R. Bartlett , Edward T. Liang , John M. Pocekay , Mark A. Staples
IPC分类号： G01N33/53 , G01N33/531 , G01N33/82
CPC分类号： G01N33/82 , Y10T436/25 , Y10T436/25125
摘要： Denaturing agents used to pretreat test samples for immunoassays are neutralized and deactivated by the addition of a treatment agent which is a combination of a buffering agent in acid form and an agent for converting the sulfhydryl groups of the denaturing agents to a non-active form such as disulfides or alkylthio groups. The treatment agent serves this function without having sufficient denaturing activity by itself to interfere with subsequent steps of the assay procedure. Also disclosed is a protocol for a vitamin B.sub.12 assay which involves a sequential rather than competitive binding of the B.sub.12 with excess intrinsic factor followed by the binding of excess enzyme-labeled B.sub.12 to any remaining intrinsic and immobilizing such intrinsic factor on a solid phase. Various problems associated with B.sub.12 assays are avoided by this technique.
摘要翻译： 用于预处理试验样品用于免疫测定的变性剂通过加入处理剂中和和失活，所述处理剂是酸形式的缓冲剂和用于将变性剂的巯基转化成非活性形式的试剂 作为二硫化物或烷硫基。 治疗剂不具有足够的变性活性来干扰随后的测定程序步骤而起作用。 还公开了一种用于维生素B12测定的方案，其涉及B12与过量内在因子的顺序而非竞争性结合，然后将过量的酶标记的B12与任何残留的内在和固定在固相上的固有因子结合。 通过这种技术避免了与B12测定相关的各种问题。
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