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    Compositions and methods for detecting small RNAs, and uses thereof
    1.
    发明授权
    Compositions and methods for detecting small RNAs, and uses thereof 有权
    用于检测小RNA的组合物和方法及其用途

    公开(公告)号：US08399222B2

    公开(公告)日：2013-03-19

    申请号：US12625609

    申请日：2009-11-25

    申请人： Amara Siva ,  Mark Alan Reynolds

    发明人： Amara Siva ,  Mark Alan Reynolds

    IPC分类号： C12P19/34 ,  C12Q1/68

    CPC分类号： C12Q1/6876 ,  C12Q1/6853 ,  C12Q2600/178 ,  C12Q2565/537 ,  C12Q2565/525 ,  C12Q2537/143 ,  C12Q2525/301

    摘要： Compositions and methods are provided for the detection of small RNA target nucleic acids, preferably miRNA target nucleic acids, wherein the compositions and methods provide for sensitive and specific detection of the target nucleic acids. The compositions and methods include using one or more of a first amplification oligomer that is preferably an extender primer, a target capture oligomer that is preferably at least partially double stranded, a promoter primer/provider, a reverse primer that is preferably a universal primer and a detection probe. The compositions and methods are useful for diagnostics, prognostics, monitoring the effectiveness of treatment and/or determining a treatment.

    摘要翻译： 提供组合物和方法用于检测小RNA靶核酸，优选miRNA靶核酸，其中组合物和方法提供对靶核酸的敏感和特异性检测。 组合物和方法包括使用一种或多种优选扩增引物的第一扩增寡聚物，优选至少部分双链的靶捕获低聚物，启动子引物/提供者，优选通用引物的反向引物和 检测探针。 组合物和方法可用于诊断，预后，监测治疗的有效性和/或确定治疗。

    Biological stimulant foaming application
    2.
    发明申请
    Biological stimulant foaming application 审中-公开
    生物兴奋剂发泡应用

    公开(公告)号：US20110135504A1

    公开(公告)日：2011-06-09

    申请号：US12927337

    申请日：2010-11-12

    申请人： Mark Alan Reynolds

    发明人： Mark Alan Reynolds

    IPC分类号： F04F5/00

    CPC分类号： F04F5/00

    摘要： In conclusion, our claim is the process of introducing biological stimulants as manufactured by various entities through a compressed air foaming procedure. This process includes the use of a typical hydraulic jet cleaner truck to which a specialized foam generating system is integrated. The foam generating system consists of a solution pump through which the chemical agent is mixed into a stream of compressed air to create a foam, which, when used to apply within a pipe, is then ejected from the terminus of a specialized nozzle as described in paragraph 0009 above. When used for structural applications other than pipe, the foam may be applied by the foaming system without utilization of the hydraulic jet cleaner or via a portable independent foam generating system instead. The use of a hydraulic jet cleaner itself is a significantly unique concept in applying these forms of chemicals as they are generally just poured or sprayed onto the target area or down a drain.

    摘要翻译： 总之，我们的主张是通过压缩空气发泡程序引入各种实体制造的生物兴奋剂的过程。 该过程包括使用典型的液压喷射清洁器卡车，其中集成了专门的泡沫发生系统。 泡沫发生系统由溶液泵组成，化学试剂通过该溶液泵混合成压缩空气流以产生泡沫，当将其用于施加在管内时，该泡沫随后从专用喷嘴的末端排出，如 上文第0009段。 当用于除管道之外的结构应用时，可以通过发泡系统施加泡沫，而不使用液压喷射清洁器或通过便携式独立泡沫发生系统。 使用液压喷射清洁机本身是应用这些形式的化学品的一个非常独特的概念，因为它们通常刚刚浇注或喷射到目标区域或排水管上。