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公开(公告)号：US06962813B2
公开(公告)日：2005-11-08
申请号：US10153437
申请日：2002-05-21
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及特异性结合铜绿假单胞菌粘液样多糖的肽，特别是人单克隆抗体。 本发明进一步提供了在诊断，预防和治疗铜绿假单胞菌感染和相关病症（例如囊性纤维化）中使用这些肽的方法。 本发明的一些抗体增强了对铜绿假单胞菌的多个粘液样菌株的调理吞噬性杀伤。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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公开(公告)号：US20060153856A1
公开(公告)日：2006-07-13
申请号：US11171085
申请日：2005-06-29
申请人： Gerald Pier , Michael Preston , Lisa Cavacini , Marshall Posner
发明人： Gerald Pier , Michael Preston , Lisa Cavacini , Marshall Posner
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
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公开(公告)号：US20060115486A1
公开(公告)日：2006-06-01
申请号：US11111688
申请日：2005-04-21
IPC分类号： A61K39/40
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
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公开(公告)号：US20060235206A1
公开(公告)日：2006-10-19
申请号：US11471857
申请日：2006-06-21
申请人： Gerald Pier , Michael Preston , Lisa Cavacini , Marshall Posner
发明人： Gerald Pier , Michael Preston , Lisa Cavacini , Marshall Posner
IPC分类号： C07K16/12
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
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公开(公告)号：US07119172B2
公开(公告)日：2006-10-10
申请号：US10440522
申请日：2003-05-16
IPC分类号： C07K14/00 , C07K16/00 , G01N33/53 , A61K39/395
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
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