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公开(公告)号：US06962813B2
公开(公告)日：2005-11-08
申请号：US10153437
申请日：2002-05-21
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及特异性结合铜绿假单胞菌粘液样多糖的肽，特别是人单克隆抗体。 本发明进一步提供了在诊断，预防和治疗铜绿假单胞菌感染和相关病症（例如囊性纤维化）中使用这些肽的方法。 本发明的一些抗体增强了对铜绿假单胞菌的多个粘液样菌株的调理吞噬性杀伤。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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公开(公告)号：US07119172B2
公开(公告)日：2006-10-10
申请号：US10440522
申请日：2003-05-16
IPC分类号： C07K14/00 , C07K16/00 , G01N33/53 , A61K39/395
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
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公开(公告)号：US07230087B2
公开(公告)日：2007-06-12
申请号：US11171085
申请日：2005-06-29
IPC分类号： C07K16/00 , A61K39/395 , A61K39/40 , G01N33/53
CPC分类号： C07K16/1214 , A61K39/00 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及特异性结合铜绿假单胞菌粘液样多糖的肽，特别是人单克隆抗体。 本发明进一步提供了在诊断，预防和治疗铜绿假单胞菌感染和相关病症（例如囊性纤维化）中使用这些肽的方法。 本发明的一些抗体增强了对铜绿假单胞菌的多个粘液样菌株的调理吞噬性杀伤。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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4.发明授权Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof 有权聚-N-乙酰氨基葡萄糖（PNAG / dPNAG）结合肽及其使用方法公开(公告)号：US08435515B2
公开(公告)日：2013-05-07
申请号：US13334807
申请日：2011-12-22
IPC分类号： A61K38/00 , A61K39/395 , A61K39/40 , C07K1/00 , C07K16/00
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。 本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。 本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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5.发明申请POLY-N-ACETYL GLUCOSAMINE (PNAG/dPNAG)-BINDING PEPTIDES AND METHODS OF USE THEREOF 有权聚N-乙酰葡萄糖胺（PNAG / dPNAG）联蛋白及其使用方法公开(公告)号：US20120201833A1
公开(公告)日：2012-08-09
申请号：US13334807
申请日：2011-12-22
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。 本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。 本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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公开(公告)号：US08410249B2
公开(公告)日：2013-04-02
申请号：US13334869
申请日：2011-12-22
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
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7.发明申请POLY-N-ACETYL GLUCOSAMINE (PNAG/dPNAG)-BINDING PEPTIDES AND METHODS OF USE THEREOF 有权聚N-乙酰葡萄糖胺（PNAG / dPNAG）联蛋白及其使用方法公开(公告)号：US20110002932A1
公开(公告)日：2011-01-06
申请号：US12824510
申请日：2010-06-28
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。 本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。 本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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8.发明授权Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof 有权聚-N-乙酰氨基葡萄糖（PNAG / dPNAG）结合肽及其使用方法公开(公告)号：US07786255B2
公开(公告)日：2010-08-31
申请号：US11111688
申请日：2005-04-21
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。 本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。 本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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9.发明授权Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof 有权聚-N-乙酰氨基葡萄糖（PNAG / dPNAG）结合肽及其使用方法公开(公告)号：US08252894B2
公开(公告)日：2012-08-28
申请号：US13103532
申请日：2011-05-09
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译： 本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。 本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。 本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。 还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。
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公开(公告)号：US20120201834A1
公开(公告)日：2012-08-09
申请号：US13334869
申请日：2011-12-22
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
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