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公开(公告)号：US20090004693A1
公开(公告)日：2009-01-01
申请号：US11629882
申请日：2005-06-16
申请人： Cornelis Maria Sagt , Noel Nicolaas Maria Elisabeth Peij , Linda De Lange , Martina Beishuizen , Serge Petrus Donkers
发明人： Cornelis Maria Sagt , Noel Nicolaas Maria Elisabeth Peij , Linda De Lange , Martina Beishuizen , Serge Petrus Donkers
CPC分类号： C07K14/395
摘要： The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity to secrete a polypeptide of interest.
摘要翻译： 本发明涉及具有对应于SEC61多肽的至少一种活性的活性的多肽，编码这些多肽的多核苷酸及其在制备适合于产生感兴趣多肽的宿主细胞中的用途。 这样的宿主细胞可能具有增加的分泌感兴趣的多肽的能力。
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2.发明授权Recombinant host cell with deficiency in non-ribosomal peptide synthase production 有权具有非核糖体肽合成酶生产缺陷的重组宿主细胞公开(公告)号：US08945898B2
公开(公告)日：2015-02-03
申请号：US13806128
申请日：2011-07-01
申请人： Noel Nicolaas Maria Elisabeth Van Peij , Marcus Hans , Martina Beishuizen , Dick Schipper , Robertus Antonius Mijndert Van Der Hoeven , Olaf Leonardus Schouten
发明人： Noel Nicolaas Maria Elisabeth Van Peij , Marcus Hans , Martina Beishuizen , Dick Schipper , Robertus Antonius Mijndert Van Der Hoeven , Olaf Leonardus Schouten
摘要： The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.
摘要翻译： 本发明涉及通过微生物发酵生产感兴趣的化合物的方法，其中使用的微生物宿主细胞在其基因组中已被修饰，从而导致至少一种非核糖体肽合成酶的产生缺陷 。 本发明还涉及在其基因组中已被修饰的微生物宿主细胞，从而导致至少一种非核糖体肽合酶的产生缺陷。 本发明还涉及目的化合物。
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公开(公告)号：US20130144034A1
公开(公告)日：2013-06-06
申请号：US13806128
申请日：2011-07-01
申请人： Noel Nicolaas Maria Elisabeth Van Peij , Marcus Hans , Martina Beishuizen , Dick Schipper , Robertus Antonius Mijndert Van Der Hoeven , Olaf Leonardus Schouten
发明人： Noel Nicolaas Maria Elisabeth Van Peij , Marcus Hans , Martina Beishuizen , Dick Schipper , Robertus Antonius Mijndert Van Der Hoeven , Olaf Leonardus Schouten
IPC分类号： C12P21/02
摘要： The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.
摘要翻译： 本发明涉及通过微生物发酵生产感兴趣的化合物的方法，其中使用的微生物宿主细胞在其基因组中已被修饰，从而导致至少一种非核糖体肽合成酶的产生缺陷 。 本发明还涉及在其基因组中已被修饰的微生物宿主细胞，从而导致至少一种非核糖体肽合酶的产生缺陷。 本发明还涉及目的化合物。
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公开(公告)号：US07968312B2
公开(公告)日：2011-06-28
申请号：US11629882
申请日：2005-06-16
申请人： Cornelis Maria Jacobus Sagt , Nöel Nicolaas Maria Elisabeth Van Peij , Linda De Lange , Martina Beishuizen , Serge Petrus Donkers
发明人： Cornelis Maria Jacobus Sagt , Nöel Nicolaas Maria Elisabeth Van Peij , Linda De Lange , Martina Beishuizen , Serge Petrus Donkers
CPC分类号： C07K14/395
摘要： The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity to secrete a polypeptide of interest.
摘要翻译： 本发明涉及具有对应于SEC61多肽的至少一种活性的活性的多肽，编码这些多肽的多核苷酸及其在制备适合于产生感兴趣多肽的宿主细胞中的用途。 这样的宿主细胞可能具有增加的分泌感兴趣的多肽的能力。
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