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1.发明授权Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors 失效糜蛋白酶超家族的丝氨酸蛋白酶突变体对其同源抑制剂的抑制具有抗性
公开(公告)号：US5304482A
公开(公告)日：1994-04-19
申请号：US589554
申请日：1990-09-28
IPC分类号： A61K38/46 , A61K31/00 , A61K38/00 , A61K38/48 , A61P7/00 , A61P7/02 , A61P9/10 , C07H21/04 , C07K14/005 , C07K14/195 , C07K14/47 , C07K14/81 , C12N1/21 , C12N9/04 , C12N9/50 , C12N9/64 , C12N9/72 , C12N9/76 , C12N9/99 , C12N15/09 , C12N15/10 , C12N15/57 , C12N15/58 , C12N15/71 , C12N15/85 , C12R1/19 , C12R1/91 , C12N15/00
CPC分类号： C12N9/6459 , C07K14/8132 , C12N15/102 , C12N15/71 , C12N15/85 , C12N9/50 , C12N9/6427 , C12Y304/21069 , A61K38/00 , C12N2800/108 , C12N2830/00 , C12N2830/55
摘要： The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
摘要翻译： 本发明涉及对其抑制作用有抑制作用的糜蛋白酶超家族的丝氨酸蛋白酶突变体及其编码基因。 本发明还涉及抑制本发明的丝氨酸蛋白酶突变体的丝氨酸蛋白酶抑制剂突变体和编码本发明的丝氨酸蛋白酶突变体的基因。 丝氨酸蛋白酶突变体和丝氨酸蛋白酶抑制剂突变体可用作例如药理学试剂。
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公开(公告)号：US5728564A
公开(公告)日：1998-03-17
申请号：US651055
申请日：1996-05-21
申请人： Joseph F. Sambrook , Edwin L. Madison , Elizabeth J. Goldsmith , Maryjane H. Gething , Robert D. Gerard
发明人： Joseph F. Sambrook , Edwin L. Madison , Elizabeth J. Goldsmith , Maryjane H. Gething , Robert D. Gerard
IPC分类号： A61K38/46 , A61K31/00 , A61K38/00 , A61P7/00 , A61P7/02 , A61P9/10 , C07H21/04 , C07K14/005 , C07K14/195 , C07K14/47 , C07K14/81 , C12N9/04 , C12N9/50 , C12N9/64 , C12N9/72 , C12N9/76 , C12N9/99 , C12N15/09 , C12N15/10 , C12N15/57 , C12N15/58 , C12N15/71 , C12N15/85 , C12R1/91 , C12N15/00
CPC分类号： C12N9/6459 , C07K14/8132 , C12N15/102 , C12N15/71 , C12N15/85 , C12N9/50 , C12N9/6427 , C12Y304/21069 , A61K38/00 , C12N2800/108 , C12N2830/00 , C12N2830/55
摘要： The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
摘要翻译： 本发明涉及对其抑制作用有抑制作用的糜蛋白酶超家族的丝氨酸蛋白酶突变体及其编码基因。 本发明还涉及抑制本发明的丝氨酸蛋白酶突变体的丝氨酸蛋白酶抑制剂突变体和编码本发明的丝氨酸蛋白酶突变体的基因。 丝氨酸蛋白酶，突变体和丝氨酸蛋白酶抑制剂突变体可用作例如药理学试剂。
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3.发明授权Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same 失效糜蛋白酶超家族的丝氨酸蛋白酶突变体对其同源抑制剂的抑制和编码相同的丝氨酸蛋白酶抑制剂突变体的基因和编码相同基因的基因具有抗性
公开(公告)号：US5550042A
公开(公告)日：1996-08-27
申请号：US434748
申请日：1989-11-13
申请人： Joseph F. Sambrook , Edwin L. Madison , Elizabeth J. Goldsmith , Maryjane H. Gething , Robert D. Gerard
发明人： Joseph F. Sambrook , Edwin L. Madison , Elizabeth J. Goldsmith , Maryjane H. Gething , Robert D. Gerard
IPC分类号： A61K38/46 , A61K31/00 , A61K38/00 , A61P7/00 , A61P7/02 , A61P9/10 , C07H21/04 , C07K14/005 , C07K14/195 , C07K14/47 , C07K14/81 , C12N9/04 , C12N9/50 , C12N9/64 , C12N9/72 , C12N9/76 , C12N9/99 , C12N15/09 , C12N15/10 , C12N15/57 , C12N15/58 , C12N15/71 , C12N15/85 , C12R1/91 , C12N15/01 , C12N15/63
CPC分类号： C12N9/6459 , C07K14/8132 , C12N15/102 , C12N15/71 , C12N15/85 , C12N9/50 , C12N9/6427 , C12Y304/21069 , A61K38/00 , C12N2800/108 , C12N2830/00 , C12N2830/55
摘要： The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
摘要翻译： 本发明涉及对其抑制作用有抑制作用的糜蛋白酶超家族的丝氨酸蛋白酶突变体及其编码基因。 本发明还涉及抑制本发明的丝氨酸蛋白酶突变体的丝氨酸蛋白酶抑制剂突变体和编码本发明的丝氨酸蛋白酶突变体的基因。 丝氨酸蛋白酶，突变体和丝氨酸蛋白酶抑制剂突变体可用作例如药理学试剂。
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公开(公告)号：US5866413A
公开(公告)日：1999-02-02
申请号：US978627
申请日：1997-11-25
申请人： Joseph F. Sambrook , Edwin L. Madison , Elizabeth J. Goldsmith , Maryjane H. Gething , Robert D. Gerard
发明人： Joseph F. Sambrook , Edwin L. Madison , Elizabeth J. Goldsmith , Maryjane H. Gething , Robert D. Gerard
CPC分类号： C12N9/6424
摘要： The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
摘要翻译： 本发明涉及对其抑制作用有抑制作用的糜蛋白酶超家族的丝氨酸蛋白酶突变体及其编码基因。 本发明还涉及抑制本发明的丝氨酸蛋白酶突变体的丝氨酸蛋白酶抑制剂突变体和编码本发明的丝氨酸蛋白酶突变体的基因。 丝氨酸蛋白酶，突变体和丝氨酸蛋白酶抑制剂突变体可用作例如药理学试剂。
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5.发明授权Genes encoding serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors 失效编码糜蛋白酶超家族的丝氨酸蛋白酶突变体的基因对其同源抑制剂的抑制具有抗性
公开(公告)号：US5486602A
公开(公告)日：1996-01-23
申请号：US168366
申请日：1993-12-17
IPC分类号： A61K38/46 , A61K31/00 , A61K38/00 , A61K38/48 , A61P7/00 , A61P7/02 , A61P9/10 , C07H21/04 , C07K14/005 , C07K14/195 , C07K14/47 , C07K14/81 , C12N1/21 , C12N9/04 , C12N9/50 , C12N9/64 , C12N9/72 , C12N9/76 , C12N9/99 , C12N15/09 , C12N15/10 , C12N15/57 , C12N15/58 , C12N15/71 , C12N15/85 , C12R1/19 , C12R1/91
CPC分类号： C12N9/6459 , C07K14/8132 , C12N15/102 , C12N15/71 , C12N15/85 , C12N9/50 , C12N9/6427 , C12Y304/21069 , A61K38/00 , C12N2800/108 , C12N2830/00 , C12N2830/55
摘要： The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
摘要翻译： 本发明涉及对其抑制作用有抑制作用的糜蛋白酶超家族的丝氨酸蛋白酶突变体及其编码基因。 本发明还涉及抑制本发明的丝氨酸蛋白酶突变体的丝氨酸蛋白酶抑制剂突变体和编码本发明的丝氨酸蛋白酶突变体的基因。 丝氨酸蛋白酶突变体和丝氨酸蛋白酶抑制剂突变体可用作例如药理学试剂。
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