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公开(公告)号：US20250162942A1
公开(公告)日：2025-05-22
申请号：US18406058
申请日：2024-01-05
Applicant: Massachusetts Institute of Technology
Inventor： Yet-Ming Chiang , Camden Hunt , Jacqueline Prawira , Benjamin Mowbray
IPC: C04B22/12
Abstract: Disclosed herein are silicates and/or salts and methods of production and uses thereof. For example, methods of producing an amorphous silicate and/or a salt from materials comprising silicates are disclosed. As another example, use of silicates and/or salts in the formation of cementitious materials is also disclosed.
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公开(公告)号：US20250154513A1
公开(公告)日：2025-05-15
申请号：US18927790
申请日：2024-10-25
Applicant: Massachusetts Institute of Technology
Inventor： Pranam Chatterjee , Noah Michael Jakimo , Joseph M. Jacobson
Abstract: Applications of a Streptococcus Cas9 ortholog from Streptococcus macacae (Smac Cas9), possessing minimal adenine-rich PAM specificity, include an isolated Streptococcus macacae Cas9 protein or transgene expression thereof, a CRISPR-associated DNA endonuclease with PAM interacting domain amino acid sequences that are at least 80% identical to that of the isolated Streptococcus macacae Cas9 protein, and an isolated, engineered Streptococcus pyogenes Cas9 (Spy Cas9) protein with a PID as either the PID amino acid composition of the isolated Streptococcus macacae Cas9 (Smac Cas9) protein or of a CRISPR-associated DNA endonuclease with PID amino acid sequences that are at least 80% identical to that of the isolated Streptococcus macacae Cas9 protein. A method for altering expression of at least one gene product employs Streptococcus macacae Cas9 endonucleases in complex with guide RNA, for specific recognition and activity on a DNA target immediately upstream of either an “NAA” or “NA” or “NAAN” PAM sequence.
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公开(公告)号：US20250152451A1
公开(公告)日：2025-05-15
申请号：US18837046
申请日：2023-05-16
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Emily Alexis KAMIENSKI , Haruhiko Harry ASADA , Karen L. CHEN
IPC: A61H3/00
Abstract: Systems and devices are disclosed for mobility assistance of users with instability or reduced mobility when walking. The mobility device can be a garment (e.g., pants, shorts) that includes a wearable harness embedded or otherwise associated with the garment in a manner that allows the garment to be worn without the harness being outwardly noticeable. The garment can be worn in conjunction with being connected to a walker or other mobility aid vehicle, as well as in everyday use. The harness associated with the garment provides support for the user while a majority of the harness is invisible from outside the garment. A connector can be utilized in conjunction with the same to help manage the connection between the harness and the mobility aid vehicle. The connector can include the ability to mitigate or stop a fall in response to parameters detected by sensors associated with the garment or system.
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公开(公告)号：US12297506B2
公开(公告)日：2025-05-13
申请号：US17688985
申请日：2022-03-08
Applicant: Massachusetts Institute of Technology
IPC: C12Q1/6886 , A61K31/7125 , C12N15/113 , C12Q1/6811 , C12Q1/6897
Abstract: Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. The cell state classifiers of the present disclosure are designed to incorporate multiple genetic circuits integrated together by transcriptional or translational control. Multiple inputs can be sensed simultaneously by coupling their detection to different portions of the genetic circuit such that the output molecule is produced only when the correct input profile of miRNAs is detected. The genetic circuits and cell state classifiers may be used in various applications (e.g., therapeutic or diagnostic applications).
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公开(公告)号：US12296127B2
公开(公告)日：2025-05-13
申请号：US18125810
申请日：2023-03-24
Applicant: Massachusetts Institute of Technology
Inventor： Michael J. Cima , Heejin Lee
IPC: A61M31/00 , A61K9/00 , A61K31/167 , A61M25/01
Abstract: An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.
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Patent Agency Ranking
公开(公告)号：US20250148354A1
公开(公告)日：2025-05-08
申请号：US18503166
申请日：2023-11-06
Inventor： Abhin Shah , Maohao Shen , Jongha Ryu , Subhro Das , Prasanna Sattigeri , Yuheng Bu , Gregory Wornell
IPC: G06N20/00
Abstract: A computer-implemented method and system for generating a predictive model include a computation engine learning a predictive model having missing or crippled data. A processor applies a formulated problem of missing or crippled data based learning to the predictive model. The computation engine reduces one or more tasks associated with the predictive model to a quadratically constrained quadratic problem (QCQP). The computation engine characterizes one or more solutions associated with the QCQP, where each of the one or more solutions is a loss function value.
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公开(公告)号：US12293871B2
公开(公告)日：2025-05-06
申请号：US18476886
申请日：2023-09-28
Inventor： Brian Labombard , Robert S. Granetz , James Irby , Rui Vieira , William Beck , Daniel Brunner , Jeffrey Doody , Martin Greenwald , Zachary Hartwig , Philip Michael , Robert Mumgaard , Alexey Radovinsky , Shunichi Shiraiwa , Brandon N. Sorbom , John Wright , Lihua Zhou
Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.
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公开(公告)号：US20250139336A1
公开(公告)日：2025-05-01
申请号：US18836071
申请日：2023-02-06
Applicant: NANYANG TECHNOLOGICAL UNIVERSITY , BROWN UNIVERSITY , Massachusetts Institute of Technology
Inventor： Subra SURESH , George Em KARNIADAKIS , Enrui ZHANG , Ming DAO
Abstract: Methods involving physics-informed deep learning to help solve inverse problems of solid materials/structures related to unknown geometry include (1) identifying and characterizing unknown materials/structures and defects with accuracy and predictive capability and limited non-destructive measurements, and/or (2) designing geometrical features and parameters of solid materials and structures to achieve optimized and/or improved performance.
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公开(公告)号：US20250136869A1
公开(公告)日：2025-05-01
申请号：US18927122
申请日：2024-10-25
Applicant: Massachusetts Institute of Technology
Inventor： Jack Forman , Ozgun Kilic Afsar , Sarah Nicita , Rosalie Hsin-Ju Lin , Cedric Honnet , Neil Gershenfeld , Hiroshi Ishii
Abstract: Liquid Crystal Elastomer (LCE) fibers, an apparatus for manufacturing, and a method for using the apparatus are provided. LCE fibers formed from each of a plurality of resin recipes can undergo reversible temperature driven actuation of the fiber. Each of the resin recipes forms a fiber having a different actuation temperature. The apparatus includes: an extrusion device, a drawing bobbin, a coating basin, a collector bobbin, a first plurality of curing devices, and a second plurality of curing devices, to transform a resin recipe into a LCE fiber. In operation, the extrusion device extrudes the resin through to the first plurality of curing devices for a partial cure. Once in contact with drawing bobbin the resin is coated in a fluid, and then pull through the second plurality of curing devices for a final cure by collector bobbin, where it can be collected and post-processed.
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公开(公告)号：US20250136759A1
公开(公告)日：2025-05-01
申请号：US18836707
申请日：2023-02-09
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Michael S. STRANO , Yuwen ZENG , Ge ZHANG
Abstract: Structural variants of 2D polymers and composites thereof are described.
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