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公开(公告)号：US10308660B2
公开(公告)日：2019-06-04
申请号：US15736989
申请日：2016-06-15
申请人： Zhuoliang Chen , Jorge Garcia Fortanet , Matthew J. LaMarche , Martin Sendzik , Victoriano Tamez, Jr. , Bing Yu
发明人： Zhuoliang Chen , Jorge Garcia Fortanet , Matthew J. LaMarche , Martin Sendzik , Victoriano Tamez, Jr. , Bing Yu
IPC分类号： C07D401/04 , C07D491/107 , C07D401/14 , A61P35/00
摘要： The present invention relates to compounds of formula I: in which X1, X2, X3, Y1, Y2, Y3, R1, R2, R3a, R4a, R4b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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公开(公告)号：US10093646B2
公开(公告)日：2018-10-09
申请号：US15110498
申请日：2015-01-16
申请人： Christine Hiu-Tung Chen , Zhuoliang Chen , Jorge Garcia Fortanet , Denise Grunenfelder , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Travis Matthew Stams , Sarah Williams
发明人： Christine Hiu-Tung Chen , Zhuoliang Chen , Jorge Garcia Fortanet , Denise Grunenfelder , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Travis Matthew Stams , Sarah Williams
IPC分类号： C07D401/04 , C07D409/14 , C07D471/04 , C07D403/04 , C07D401/14 , C07D487/04
摘要： The present invention relates to compounds of formula I: in which m, Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a and R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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公开(公告)号：US10077276B2
公开(公告)日：2018-09-18
申请号：US15110511
申请日：2015-01-16
申请人： Christine Hiu-Tung Chen , Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Troy Douglas Smith , Sarah Williams , John William Giraldes , Martin Sendzik , Bakary-Barry Toure
发明人： Christine Hiu-Tung Chen , Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Troy Douglas Smith , Sarah Williams , John William Giraldes , Martin Sendzik , Bakary-Barry Toure
IPC分类号： C07D498/10 , C07D241/18 , C07D241/20 , C07D401/04 , C07D403/04 , C07D471/10 , C07D491/107 , C07D495/10 , C07D401/14
摘要： The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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公开(公告)号：US20180251471A1
公开(公告)日：2018-09-06
申请号：US15736989
申请日：2016-06-15
申请人： Zhuoliang CHEN , Jorge Garcia FORTANET , Matthew J. LAMARCHE , Martin SENDZIK , Victoriano TAMEZ, JR. , Bing YU
发明人： Zhuoliang Chen , Jorge Garcia Fortanet , Matthew J. LaMarche , Martin Sendzik , Victoriano Tamez, JR. , Bing Yu
IPC分类号： C07D491/107 , C07D401/14 , C07D401/04 , A61P35/00
CPC分类号： C07D491/107 , A61P35/00 , C07D401/04 , C07D401/14
摘要： The present invention relates to compounds of formula I: in which X1, X2, X3, Y1, Y2, Y3, R1, R2, R3a, R4a, R4b, R5a, R5b, R6a and R6b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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公开(公告)号：US09938295B2
公开(公告)日：2018-04-10
申请号：US15110511
申请日：2015-01-16
申请人： Christine Hiu-Tung Chen , Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Troy Douglas Smith , Sarah Williams , John William Giraldes , Martin Sendzik , Bakary-Barry Toure
发明人： Christine Hiu-Tung Chen , Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Troy Douglas Smith , Sarah Williams , John William Giraldes , Martin Sendzik , Bakary-Barry Toure
IPC分类号： C07D498/10 , C07D241/18 , C07D241/20 , C07D401/04 , C07D401/14 , C07D403/04 , C07D471/10 , C07D491/107 , C07D495/10
摘要： The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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公开(公告)号：US08426356B2
公开(公告)日：2013-04-23
申请号：US12333602
申请日：2008-12-12
IPC分类号： A61K31/437
CPC分类号： C07K5/06139 , A61K38/00 , A61K38/05 , A61K45/06 , C07D417/04 , Y02A50/473
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善疾病，特别是细菌感染的有机化合物。
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公开(公告)号：US20100267757A1
公开(公告)日：2010-10-21
申请号：US12828737
申请日：2010-07-01
IPC分类号： A61K31/437 , A61P3/04 , A61P17/10 , C07D513/22
CPC分类号： C07K5/06139 , A61K38/00 , Y02A50/473
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善疾病的有机化合物。
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8.发明授权Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof 有权多羟基二烯基内酯的合成技术和中间体及其模拟物公开(公告)号：US07723536B2
公开(公告)日：2010-05-25
申请号：US12072730
申请日：2008-02-28
申请人： Amos B. Smith, III , Thomas J. Beauchamp , Matthew J. LaMarche , Yuping Qiu , Michael D. Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi
发明人： Amos B. Smith, III , Thomas J. Beauchamp , Matthew J. LaMarche , Yuping Qiu , Michael D. Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi
CPC分类号： C07C271/12 , C07B2200/07 , C07D213/30 , C07D263/22 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D339/08 , C07D407/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/1804 , C07F7/1892 , C07F9/5428 , C07F9/5442
摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
摘要翻译： 提供了可用于制备含内酯化合物如discodermolide的合成方法和中间体以及模拟discodermolide的化学或生物活性的化合物。
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公开(公告)号：US20100093615A1
公开(公告)日：2010-04-15
申请号：US12519872
申请日：2007-12-19
CPC分类号： C12P17/185 , C07D513/22 , C12R1/01
摘要： This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and derivatives thereof, and to methods for obtaining such compounds.
摘要翻译： 本发明涉及一种新的抗生素化合物，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。
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10.发明申请公开(公告)号：US20180362496A1
公开(公告)日：2018-12-20
申请号：US16117674
申请日：2018-08-30
申请人： Christine Hiu-Tung Chen , Zhuoliang Chen , Jorge Garcia Fortanet , Denise Grunenfelder , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Travis Matthew Stams , Sarah Williams
发明人： Christine Hiu-Tung Chen , Zhuoliang Chen , Jorge Garcia Fortanet , Denise Grunenfelder , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Travis Matthew Stams , Sarah Williams
IPC分类号： C07D401/04 , C07D401/14 , C07D241/26 , C07D471/04 , C07D409/14 , C07D239/48 , C07D487/04 , C07D403/04 , C07D249/14
摘要： The present invention relates to compounds of formula I: in which m, Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a and R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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