MIXTURE OF AT LEAST TWO FUSION PROTEINS, THE PRODUCTION THEREOF AND THE USE OF THE SAME
    1.
    发明申请
    MIXTURE OF AT LEAST TWO FUSION PROTEINS, THE PRODUCTION THEREOF AND THE USE OF THE SAME 有权
    至少两种融合蛋白的混合物,其生产及其使用

    公开(公告)号:US20120015819A1

    公开(公告)日:2012-01-19

    申请号:US13222272

    申请日:2011-08-31

    申请人: Matthias PASCHKE

    发明人: Matthias PASCHKE

    IPC分类号: C40B10/00 C40B30/04

    摘要: The present invention concerns a protein mixture comprising at least a first fusion protein comprising a protein or protein fragment, and an interaction domain and a protein translocation sequence, which effects that the fusion protein upon expression in a bacterium is translocated through the cytoplasmic membrane in an essentially unfolded state and at least a second fusion protein comprising a protein or protein fragment, and an interaction domain and a protein translocation sequence which effects that the fusion protein is translocated through the cytoplasmic membrane upon expression in a bacterium in an essentially folded state, wherein the interaction domain of the first protein can bind to those of the second protein.

    摘要翻译: 本发明涉及包含至少包含蛋白质或蛋白质片段的第一融合蛋白以及相互作用结构域和蛋白质易位序列的蛋白质混合物,所述互作用结构域和蛋白质易位序列影响在细菌中表达时的融合蛋白通过细胞质膜被转位 基本上解折叠状态,以及至少第二融合蛋白,其包含蛋白质或蛋白质片段,以及相互作用结构域和蛋白质易位序列,其在基本折叠状态下在细菌中表达时影响融合蛋白被转位穿过细胞质膜,其中 第一蛋白质的相互作用结构域可以结合第二蛋白质的相互作用结构域。

    Mixture of at least two fusion proteins, the production thereof and the use of the same
    2.
    发明授权
    Mixture of at least two fusion proteins, the production thereof and the use of the same 有权
    至少两种融合蛋白的混合物,其生产和使用它们

    公开(公告)号:US08629088B2

    公开(公告)日:2014-01-14

    申请号:US13222272

    申请日:2011-08-31

    申请人: Matthias Paschke

    发明人: Matthias Paschke

    摘要: The present invention concerns a protein mixture comprising at least a first fusion protein comprising a protein or protein fragment, and an interaction domain and a protein translocation sequence, which effects that the fusion protein upon expression in a bacterium is translocated through the cytoplasmic membrane in an essentially unfolded state and at least a second fusion protein comprising a protein or protein fragment, and an interaction domain and a protein translocation sequence which effects that the fusion protein is translocated through the cytoplasmic membrane upon expression in a bacterium in an essentially folded state, wherein the interaction domain of the first protein can bind to those of the second protein.

    摘要翻译: 本发明涉及包含至少包含蛋白质或蛋白质片段的第一融合蛋白以及相互作用结构域和蛋白质易位序列的蛋白质混合物,所述互作用结构域和蛋白质易位序列影响在细菌中表达时的融合蛋白通过细胞质膜被转位 基本上解折叠状态,以及至少第二融合蛋白,其包含蛋白质或蛋白质片段,以及相互作用结构域和蛋白质易位序列,其在基本折叠状态下在细菌中表达时影响融合蛋白被转位穿过细胞质膜,其中 第一蛋白质的相互作用结构域可以结合第二蛋白质的相互作用结构域。

    Mixture of at Least Two Fusion Proteins as Well as Their Production and Use
    3.
    发明申请
    Mixture of at Least Two Fusion Proteins as Well as Their Production and Use 审中-公开
    最少两种融合蛋白的混合物及其生产和使用

    公开(公告)号:US20080287304A1

    公开(公告)日:2008-11-20

    申请号:US10537588

    申请日:2003-12-04

    申请人: Matthias Paschke

    发明人: Matthias Paschke

    摘要: The present invention concerns a protein mixture comprising at least a first fusion protein comprising a protein or protein fragment, and an interaction domain and a protein translocation sequence, which effects that the fusion protein upon expression in a bacterium is translocated through the cytoplasmic membrane in an essentially unfolded state and at least a second fusion protein comprising a protein or protein fragment, and an interaction domain and a protein translocation sequence which effects that the fusion protein is translocated through the cytoplasmic membrane upon expression in a bacterium in an essentially folded state, wherein the interaction domain of the first protein can bind to those of the second protein.

    摘要翻译: 本发明涉及包含至少包含蛋白质或蛋白质片段的第一融合蛋白以及相互作用结构域和蛋白质易位序列的蛋白质混合物,所述互作用结构域和蛋白质易位序列影响在细菌中表达时的融合蛋白通过细胞质膜被转位 基本上解折叠状态,以及至少第二融合蛋白,其包含蛋白质或蛋白质片段,以及相互作用结构域和蛋白质易位序列,其在基本折叠状态下在细菌中表达时影响融合蛋白被转位穿过细胞质膜,其中 第一蛋白质的相互作用结构域可以结合第二蛋白质的相互作用结构域。