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    Process for preparing 1-phenylpyrazoles
    10.
    发明授权
    Process for preparing 1-phenylpyrazoles 有权
    1-苯基吡唑的制备方法

    公开(公告)号：US08362271B2

    公开(公告)日：2013-01-29

    申请号：US13393624

    申请日：2010-09-03

    申请人： Maximilian Dochnahl ,  Gunter Lipowsky

    发明人： Maximilian Dochnahl ,  Gunter Lipowsky

    IPC分类号： C07D231/10

    CPC分类号： C07D231/20 ,  C07D231/14

    摘要： The present invention to a process for preparing 1-phenylpyrazoles of the formula I in which each R1 is independently selected from chlorine, fluorine, alkyl, haloalkyl, alkoxy and haloalkoxy; n is 1, 2 or 3; each R2 is independently selected from cyano, nitro, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio and alkoxycarbonyl; m is 0, 1 or 2; A is alkyl, aryl or aryl-C1-C4-alkyl, where A optionally bears 1, 2, 3 or 4 substituents comprising reacting a phenyl halide of the formula (II) with apyrazole derivative of the formula (III) in which X is chlorine, iodine or bromine; and R1, n, R2, m and A are each as defined above, in the presence of a base and a catalytic system comprising a ligand and a metal compound selected from palladium compounds, iron compounds and copper compounds.

    摘要翻译： 本发明涉及一种制备式I的1-苯基吡唑的方法，其中每个R 1独立地选自氯，氟，烷基，卤代烷基，烷氧基和卤代烷氧基; n为1,2或3; 每个R 2独立地选自氰基，硝基，卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，烷硫基和烷氧基羰基; m为0,1或2; A是烷基，芳基或芳基-C 1 -C 4 - 烷基，其中A任选地带有1,2,3或4个取代基，包括使式（II）的苯基卤与式（III）的吡咯衍生物反应，其中X为 氯，碘或溴; 在碱和催化体系的存在下，R 1，n，R 2，m和A各自如上所定义，所述催化体系包含配体和选自钯化合物，铁化合物和铜化合物的金属化合物。