CHIP AND METHOD FOR DETECTING GLYCOSYLATED HEMOGLOBIN
    2.
    发明申请
    CHIP AND METHOD FOR DETECTING GLYCOSYLATED HEMOGLOBIN 审中-公开
    用于检测糖苷化HEMOGLOBIN的芯片和方法

    公开(公告)号:US20130210035A1

    公开(公告)日:2013-08-15

    申请号:US13585983

    申请日:2012-08-15

    IPC分类号: G01N33/66

    CPC分类号: G01N33/66 G01N33/723

    摘要: The present invention relates to a chip and a method for detecting HbA1c. The detection chip comprises: a substrate; and a biomolecular layer disposed on the substrate, wherein the biomolecular layer comprises a first anti-hemoglobin antibody. The biomolecular layer can bind both the glycosylated hemoglobin and the hemoglobin in the blood sample. The method for detecting HbA1c of the present invention comprises the use of a bio-detection layer that comprises anti-glycosylated hemoglobin antibody and a second hemoglobin antibody with different epitope to differentiate the glycosylated hemoglobin from the total hemoglobin. Thus, the relative amount of glycosylated hemoglobin to hemoglobin can be detected by using the detection chip and the detection method of the present invention.

    摘要翻译: 本发明涉及一种用于检测HbA1c的芯片和方法。 检测芯片包括:基板; 以及设置在所述基板上的生物分子层,其中所述生物分子层包含第一抗血红蛋白抗体。 生物分子层可以结合血液样品中的糖基化血红蛋白和血红蛋白。 检测本发明的HbA1c的方法包括使用包含抗糖基化血红蛋白抗体的生物检测层和具有不同表位的第二血红蛋白抗体,以将糖基化血红蛋白与总血红蛋白分离。 因此,可以通过使用本发明的检测芯片和检测方法来检测糖基化血红蛋白与血红蛋白的相对量。