公开(公告)号：US20230028114A1

公开(公告)日：2023-01-26

申请号：US17753803

申请日：2020-09-15

Applicant: Holger MONENSCHEIN ,  Sean MURPHY ,  Scott OLSEN ,  Natasha O'ROURKE ,  Holly REICHARD ,  Melinda DAVIS ,  Betty LAM ,  TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Holger MONENSCHEIN ,  Sean MURPHY ,  Scott OLSEN ,  Natasha O'ROURKE ,  Holly REICHARD ,  Melinda DAVIS ,  Betty LAM

IPC: A61K31/5025 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (1) and pharmaceutically acceptable salts thereof, wherein α, β, n, R4, R5, R6, R8, R9, R10, R11, X1, X2, X3 and X7 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions comprising them, and to their use for treating diseases, disorders, and conditions associated with GPR139.

公开(公告)号：US10455904B2

公开(公告)日：2019-10-29

申请号：US15927748

申请日：2018-03-21

Applicant: Melinda Davis ,  David Boobar

Inventor： Melinda Davis ,  David Boobar

IPC: A44B11/25 ,  B60N2/28

Abstract: A seat buckle that accommodates different types and styles of child seats. The standard platform can be used across a variety of baby to child seats. The belt has a button on the front, with a safety mechanism on the back that must be articulated to enable activation of the belt buckle. The buckle may take the configuration of an adapter allows a parent to install the safety buckle for a child seat. Adapter on a pre-existing seat. The belt ideally configured for a “Y” style buckle where straps extend over each shoulder and a single strap passes between the legs of the child. This allows the safety to pass or be blocked between the two belt buckle components of the shoulder straps. This also accommodates most of the buckles that are being produced.

公开(公告)号：US20180279724A1

公开(公告)日：2018-10-04

申请号：US15927748

申请日：2018-03-21

Applicant: Melinda Davis ,  David Boobar

Inventor： Melinda Davis ,  David Boobar

IPC: A44B11/25 ,  B60N2/28

CPC classification number: A44B11/2573 ,  A44B11/2511 ,  A44B11/2534 ,  A44B11/2549 ,  A44B11/2561 ,  B60N2/2812 ,  B60N2002/2815

Abstract: Improvements child or baby seat are disclosed. The improvements include a common design that accommodates different types and styles of child seats. The standard platform can be used across a variety of baby to child seats. The belt has a button on the front, with a safety mechanism on the back that must be articulated to enable activation of the belt buckle. The buckle may take4 the configuration of an adapter allows a parent to install the safety buckle for a child seat. Adapter on a pre-existing seat. The belt ideally configured for a “Y” style buckle where straps extend over each shoulder and a single strap passes between the legs of the child. This allows the safety to pass or be blocked between the two belt buckle components of the shoulder straps. This also accommodates most of the buckles that are being produced.

公开(公告)号：US20150224113A1

公开(公告)日：2015-08-13

申请号：US14693110

申请日：2015-04-22

Applicant: Jason W. Brown ,  Melinda Davis ,  Anthony Ivetac ,  Benjamin Jones ,  Andre A. Kiryanov ,  Jon Kuehler ,  Marion Lanier ,  Joanne Miura ,  Sean Murphy ,  Xiaolun Wang

Inventor： Jason W. Brown ,  Melinda Davis ,  Anthony Ivetac ,  Benjamin Jones ,  Andre A. Kiryanov ,  Jon Kuehler ,  Marion Lanier ,  Joanne Miura ,  Sean Murphy ,  Xiaolun Wang

IPC: A61K31/5513 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/444 ,  A61K31/4545

CPC classification number: C07D401/14 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/5513 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D491/10 ,  C07D491/107

Abstract: The present invention provides a method of treating acute heart failure by administering a compound of the formula: or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供了通过给予下式化合物或其药学上可接受的盐治疗急性心力衰竭的方法。