公开(公告)号：US20070040619A1

公开(公告)日：2007-02-22

申请号：US11209117

申请日：2005-08-22

申请人： Dale McQuirk ,  Michael Berens

发明人： Dale McQuirk ,  Michael Berens

IPC分类号： H03B5/12 ,  H03L7/099

CPC分类号： H01L27/101 ,  H03B2201/0266 ,  H03J2200/10

摘要： A programmable capacitor array does not require separate switching transistors because the capacitors themselves have a switchable capacitance, which capacitors are made in the manner of regular N channel transistors with their source/drains connected to each other. When a logic low is applied to the gate, the capacitance is relatively low and the capacitance is what is commonly called parasitic capacitance. The capacitance increases significantly when a logic high is applied to the gate because the logic high has the effect of inverting the channel. Thus, the capacitor array is made of transistors that themselves have switchable capacitance operated so that no separate switching transistors are required. This allows for construction of an array of unit capacitors to achieve monotonic operation and good linearity using conventional manufacturing of N channel transistors while achieving significant area savings and reduced power consumption.

摘要翻译： 可编程电容器阵列不需要单独的开关晶体管，因为电容器本身具有可切换电容，这些电容器以其源极/漏极相互连接的常规N沟道晶体管的方式制成。 当逻辑低电平施加到栅极时，电容相对较低，电容通常称为寄生电容。 当逻辑高电平施加到栅极时，电容显着增加，因为逻辑高电平具有反相通道的作用。 因此，电容器阵列由其自身具有可切换电容操作的晶体管制成，使得不需要单独的开关晶体管。 这允许使用N沟道晶体管的常规制造来实现单元电容器阵列以实现单调操作和良好的线性度，同时实现显着的面积节省和降低的功耗。

公开(公告)号：US07391278B2

公开(公告)日：2008-06-24

申请号：US11461120

申请日：2006-07-31

申请人： Michael Berens

发明人： Michael Berens

IPC分类号： H03B5/36

CPC分类号： H03F1/3205 ,  H03B5/364 ,  H03F1/0261 ,  H03F1/301 ,  H03F3/345 ,  H03F2200/114 ,  H03F2200/357 ,  H03F2200/42

摘要： Embodiments of the invention provide a low-power, high-gain amplifier for a crystal oscillator. In some embodiments, the oscillator amplifier circuit comprises two NMOS transistors stacked in series with a PMOS transistor. In various embodiments, each of the NMOS transistors is diode-connected through a resistor and has the input signal capacitively coupled onto its control terminal. The stacked amplifier raises the DC level of the amplified oscillatory signal and can support a substantial oscillation amplitude without clipping.

公开(公告)号：US20070132519A1

公开(公告)日：2007-06-14

申请号：US11297884

申请日：2005-12-09

申请人： Michael Berens ,  James Feddeler

发明人： Michael Berens ,  James Feddeler

IPC分类号： H03B5/32

CPC分类号： H03B5/366

摘要： An integrated circuit has an internal oscillator circuit for being connected to an external frequency source such as a crystal or a ceramic resonator. The internal oscillator circuit has an inverting amplifier across the frequency source terminals to establish an oscillation there. One terminal of the frequency source is coupled to one input of the comparator and to a second input of the comparator through a low pass filter. Coupling the output of the low pass filter to the second input of the comparator is for preventing a DC offset from developing between the two inputs of the comparator. The other terminal of the frequency source is coupled to the second input of the comparator through a high pass filter. The high pass filter provides the comparator with a larger voltage differential to increase noise margin. Noise margin is further improved by allowing an increase in hysteresis in the comparator.

摘要翻译： 集成电路具有用于连接到外部频率源（例如晶体或陶瓷谐振器）的内部振荡器电路。 内部振荡器电路具有跨频率源端子的反相放大器，以在那里建立振荡。 频率源的一个端子通过低通滤波器耦合到比较器的一个输入端和比较器的第二输入端。 将低通滤波器的输出耦合到比较器的第二输入端，用于防止在比较器的两个输入端之间产生直流偏移。 频率源的另一个端子通过高通滤波器耦合到比较器的第二输入端。 高通滤波器为比较器提供更大的电压差，以增加噪声容限。 通过允许比较器中的滞后增加来进一步改善噪声容限。

公开(公告)号：US20130237444A1

公开(公告)日：2013-09-12

申请号：US13798003

申请日：2013-03-12

申请人： Michael Berens ,  Jeff Kiefer ,  Seunghan Kim

发明人： Michael Berens ,  Jeff Kiefer ,  Seunghan Kim

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： This disclosure provides a glioblastoma biomarker profile comprising glioblastoma associated genetic aberrations. The profile is indicative of a cellular and physiological characteristic of a sample from a subject. The disclosure further provides methods for profiling glioblastoma cellular and physiological characteristics including subtype, survival and drug response.

摘要翻译： 本公开提供了包含胶质母细胞瘤相关遗传畸变的成胶质细胞瘤生物标志物概况。 该曲线表示来自受试者的样品的细胞和生理特性。 本公开进一步提供了形成胶质母细胞瘤细胞和生理特征的方法，包括亚型，存活和药物反应。

公开(公告)号：US07372342B2

公开(公告)日：2008-05-13

申请号：US11461155

申请日：2006-07-31

申请人： Michael Berens

发明人： Michael Berens

IPC分类号： H03B5/36

CPC分类号： H03B5/36 ,  H03K5/084

摘要： A high-performance crystal oscillator providing effective bias resistors with low power consumption and minimal substrate surface area. In various embodiments of the invention, a switched-capacitor resistor is operably coupled to circuit components, such as an oscillation source, a current source, an input buffer, or an amplifier to provide a bias resistance.

摘要翻译： 提供低功耗和最小衬底表面积的有效偏置电阻的高性能晶体振荡器。 在本发明的各种实施例中，开关电容电阻器可操作地耦合到电路部件，例如振荡源，电流源，输入缓冲器或放大器以提供偏置电阻。

公开(公告)号：US20080042770A1

公开(公告)日：2008-02-21

申请号：US11461155

申请日：2006-07-31

申请人： Michael Berens

发明人： Michael Berens

IPC分类号： H03L7/099

CPC分类号： H03B5/36 ,  H03K5/084

摘要： A high-performance crystal oscillator providing effective bias resistors with low power consumption and minimal substrate surface area. In various embodiments of the invention, a switched-capacitor resistor is operably coupled to circuit components, such as an oscillation source, a current source, an input buffer, or an amplifier to provide a bias resistance.

摘要翻译： 提供低功耗和最小衬底表面积的有效偏置电阻的高性能晶体振荡器。 在本发明的各种实施例中，开关电容电阻器可操作地耦合到电路部件，例如振荡源，电流源，输入缓冲器或放大器以提供偏置电阻。

公开(公告)号：US20070080740A1

公开(公告)日：2007-04-12

申请号：US11244515

申请日：2005-10-06

申请人： Michael Berens ,  James Feddeler ,  Dale McQuirk

发明人： Michael Berens ,  James Feddeler ,  Dale McQuirk

IPC分类号： G05F1/10

CPC分类号： G05F3/30

摘要： A reference circuit provides a reference voltage and a reference current that are both temperature and a power supply voltage independent. The reference circuit includes a bandgap reference circuit, a current source, and a resistor. The bandgap reference circuit provides a feedback voltage to control the current source and thereby generate a temperature independent voltage and a PTAT (proportional to absolute temperature) current. A resistor having a positive temperature coefficient is coupled to the feedback controlled current source to provide a CTAT (complementary to absolute temperature) current. The CTAT current is summed directly into the feedback controlled current source to produce a reference current that is substantially constant over a range of temperatures.

摘要翻译： 参考电路提供了温度和电源电压无关的参考电压和参考电流。 参考电路包括带隙参考电路，电流源和电阻器。 带隙参考电路提供反馈电压以控制电流源，从而产生与温度无关的电压和PTAT（与绝对温度成比例）的电流。 具有正温度系数的电阻器耦合到反馈控制电流源以提供CTAT（与绝对温度互补）电流。 CTAT电流直接与反馈控制的电流源相加，以产生在一定温度范围内基本恒定的参考电流。

公开(公告)号：US20080042769A1

公开(公告)日：2008-02-21

申请号：US11461120

申请日：2006-07-31

申请人： Michael Berens

发明人： Michael Berens

IPC分类号： H03L7/099

CPC分类号： H03F1/3205 ,  H03B5/364 ,  H03F1/0261 ,  H03F1/301 ,  H03F3/345 ,  H03F2200/114 ,  H03F2200/357 ,  H03F2200/42

摘要： Embodiments of the invention provide a low-power, high-gain amplifier for a crystal oscillator. In some embodiments, the oscillator amplifier circuit comprises two NMOS transistors stacked in series with a PMOS transistor. In various embodiments, each of the NMOS transistors is diode-connected through a resistor and has the input signal capacitively coupled onto its control terminal. The stacked amplifier raises the DC level of the amplified oscillatory signal and can support a substantial oscillation amplitude without clipping.

摘要翻译： 本发明的实施例提供了一种用于晶体振荡器的低功率高增益放大器。 在一些实施例中，振荡器放大器电路包括与PMOS晶体管串联堆叠的两个NMOS晶体管。 在各种实施例中，每个NMOS晶体管通过电阻二极管连接，并且具有电容耦合到其控制端上的输入信号。 堆叠放大器提高放大的振荡信号的直流电平，并且可以支持实质的振荡幅度而不会削波。

公开(公告)号：US20060128742A1

公开(公告)日：2006-06-15

申请号：US11345132

申请日：2006-02-01

申请人： David Edwards ,  Michael Berens ,  Christian Beaudry

发明人： David Edwards ,  Michael Berens ,  Christian Beaudry

IPC分类号： A61K31/4745

CPC分类号： G01N33/5011 ,  A61K31/00 ,  A61K31/192 ,  A61K31/215 ,  A61K31/381 ,  A61K31/4745 ,  A61K31/549 ,  A61K38/193 ,  A61K39/00 ,  A61K45/06 ,  G01N2500/10 ,  A61K2300/00

摘要： Methods for treating an individual having cancer are provided. The method may include administering a cell migration inhibitor and a chemotherapeutic agent to the individual to inhibit migration of cancer cell. Inhibiting cell migration may increase cell division. In this manner, the cell migration inhibitor and the chemotherapeutic agent in combination may have increased efficacy compared to the chemotherapeutic agent alone due to the increased cell division. The cell migration inhibitor may include any of the inhibitors described herein. For example, the cell migration inhibitor may be an organic molecule having a molecular weight of less than about 700, a monoclonal antibody, or a natural product.

摘要翻译： 提供了治疗患有癌症的个体的方法。 该方法可以包括向个体施用细胞迁移抑制剂和化学治疗剂以抑制癌细胞的迁移。 抑制细胞迁移可能增加细胞分裂。 以这种方式，由于细胞分裂增加，细胞迁移抑制剂和化学治疗剂的组合可能与单独的化学治疗剂相比具有增加的功效。 细胞迁移抑制剂可以包括本文所述的任何抑制剂。 例如，细胞迁移抑制剂可以是分子量小于约700的有机分子，单克隆抗体或天然产物。