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公开(公告)号:US20080176891A1
公开(公告)日:2008-07-24
申请号:US11858144
申请日:2007-09-20
申请人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号: A61K31/437 , C07D221/04 , A61P29/00 , A61P19/02 , A61P11/06
CPC分类号: C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof.The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及根据式(I)的化合物及其盐。 本发明的化合物是激酶活性的抑制剂,特别是IKK2活性。
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2.PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译: 吡咯啉化合物,其制备方法及其作为药物的用途公开(公告)号:US20100179139A1
公开(公告)日:2010-07-15
申请号:US12602619
申请日:2008-05-29
申请人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号: A61K31/437 , C07D471/04 , A61K31/506 , A61K31/541 , A61P11/02 , A61P11/06 , A61P11/00 , A61P29/00 , A61P19/10 , A61P31/18 , A61P25/00 , A61P3/10 , A61P9/10 , A61P25/28 , A61P35/00
CPC分类号: C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof.The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及根据式(I)的化合物及其盐。 本发明的化合物是激酶活性的抑制剂,特别是IKK2活性。
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3.PYRROLO[2,3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS 1KK2 INHIBITORS 审中-公开
标题翻译: 作为1KK2抑制剂的吡咯并[2,3-B]吡啶-4-基 - 苯甲酰胺化合物公开(公告)号:US20100035917A1
公开(公告)日:2010-02-11
申请号:US12442012
申请日:2007-09-20
申请人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号: A61K31/437 , C07D471/04
CPC分类号: C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to Formula (1) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular 1KK2 activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及根据式(1)的化合物及其盐。 本发明的化合物是激酶活性的抑制剂,特别是1KK2的活性。
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公开(公告)号:US20080146606A1
公开(公告)日:2008-06-19
申请号:US11858143
申请日:2007-09-20
申请人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
发明人: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC分类号: A61K31/437 , C07D221/04 , A61P11/06 , A61P19/02 , A61P29/00
CPC分类号: C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof.The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
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5.4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases 有权
标题翻译: 可用作PI3激酶抑制剂的4-甲酰胺吲唑衍生物公开(公告)号:US08163743B2
公开(公告)日:2012-04-24
申请号:US12994246
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Christian Alan Paul Smethurst , Yoshiaki Washio
IPC分类号: C07D231/56 , C07D401/04 , A61K31/416 , A61K31/4439 , A61P11/00
CPC分类号: C07D231/56
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of P13-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是P13-激酶活性的抑制剂。
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公开(公告)号:US20060040965A1
公开(公告)日:2006-02-23
申请号:US11169313
申请日:2005-06-29
申请人: Christopher Farthing , Paul Faulder , Alexander Frenkel , Martin Harrison , Xianyun Jiao , Frank Kayser , David Kopecky , Jinqian Liu , Sarah Lively , Rajiv Sharma , Stephen Shuttleworth
发明人: Christopher Farthing , Paul Faulder , Alexander Frenkel , Martin Harrison , Xianyun Jiao , Frank Kayser , David Kopecky , Jinqian Liu , Sarah Lively , Rajiv Sharma , Stephen Shuttleworth
IPC分类号: A61K31/519 , C07D487/02
CPC分类号: C07D487/04
摘要: Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided herein.
摘要翻译: 描述了调节ACK1和LCK的作用的化合物以及用于治疗ACK1和LCK介导的疾病的相关组合物方法。 在一个方面,化合物具有一般结构:其中本文提供取代基的值。
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公开(公告)号:US08765743B2
公开(公告)日:2014-07-01
申请号:US12994253
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/4439 , A61K31/5377 , A61K31/4545 , A61K31/496 , C07D401/14 , C07D413/14 , C07D405/14 , C07D471/04
CPC分类号: C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要: The invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及式(I)的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20120238571A1
公开(公告)日:2012-09-20
申请号:US13513079
申请日:2010-12-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Christian Alan Paul Smethurst
IPC分类号: C07D417/14 , A61K31/437 , A61K31/4439 , A61K31/427 , C07D413/14 , C07D471/04 , A61P11/00 , A61P37/08 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/28 , A61P1/18 , A61P13/12 , A61P35/00 , A61P15/00 , A61P41/00 , A61P25/00 , A61P11/06 , A61P19/02 , A61P1/00 , A61P9/10 , A61K31/5377
CPC分类号: C07D417/14 , C07D417/12 , C07D471/04
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20120238559A1
公开(公告)日:2012-09-20
申请号:US13513048
申请日:2010-12-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/4439 , A61P37/08 , A61P37/06 , A61P29/00 , A61P9/00 , A61P25/28 , A61P13/12 , A61P7/02 , A61P35/00 , A61P15/00 , A61P9/10 , A61P19/02 , A61P11/06 , C07D401/14 , C07D471/04 , A61K31/437 , C07D413/14 , A61K31/422 , C07D403/14 , A61K31/416 , C07D417/14 , A61K31/427 , C07D491/048 , A61K31/4355 , A61K31/5377 , A61K31/541 , A61K31/4545 , A61P11/00
CPC分类号: C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号:US20110178063A1
公开(公告)日:2011-07-21
申请号:US12994250
申请日:2009-06-03
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号: A61K31/553 , C07D413/14 , A61K31/5377 , C07D417/14 , A61K31/541 , A61K31/5386 , C07D401/14 , A61K31/454 , A61K31/427 , A61K31/496 , A61K31/4439 , C07D471/04 , A61K31/4985 , C07D487/04 , A61K31/519 , A61P11/00 , A61P37/08 , A61P9/00 , A61P19/02 , A61P25/28 , A61P1/00 , A61P7/02 , A61P29/00
CPC分类号: C07D231/56
摘要: The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译: 本发明涉及某些新的式(I)化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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