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1.发明授权Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system 有权用于成像，诊断和/或治疗中枢神经系统疾病的化合物公开(公告)号：US09314540B2
公开(公告)日：2016-04-19
申请号：US13880847
申请日：2011-10-17
申请人： Andrea Thiele , Georg Kettschau , Tobias Heinrich , Lutz Lehmann , Christer Halldin , Sangram Nag , Andrea Varrone , Balazs Gulyas
发明人： Andrea Thiele , Georg Kettschau , Tobias Heinrich , Lutz Lehmann , Christer Halldin , Sangram Nag , Andrea Varrone , Balazs Gulyas
IPC分类号： C07C211/29 , A61K51/04 , C07B59/00
CPC分类号： A61K51/04 , C07B59/001 , C07C211/29
摘要： This invention relates to novel compounds suitable as precursors for the preparation of certain 18F labelled positron emission tomography (PET) tracers. Furthermore the invention relates to the preparation of such precursor molecules and to the preparation of PET tracers by 18F labelling of such precursors.
摘要翻译： 本发明涉及适用于制备某些18F标记的正电子发射断层扫描（PET）示踪剂的前体的新化合物。 此外，本发明涉及这种前体分子的制备以及通过对这些前体进行18F标记的PET示踪剂的制备。
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2.发明申请COMPOUNDS FOR USE IN IMAGING, DIAGNOSING AND/OR TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM 审中-公开用于成像，诊断和/或治疗中枢神经系统疾病的化合物公开(公告)号：US20140193338A1
公开(公告)日：2014-07-10
申请号：US14006325
申请日：2012-03-20
申请人： Andrea Thiele , Georg Kettschau , Tobias Heinrich , Lutz Lehmann , Christer Halldin , Sangram Nag , Andrea Varrone , Balazs Gulyas
发明人： Andrea Thiele , Georg Kettschau , Tobias Heinrich , Lutz Lehmann , Christer Halldin , Sangram Nag , Andrea Varrone , Balazs Gulyas
IPC分类号： A61K49/00 , C07C211/42
CPC分类号： A61K49/0004 , A61K51/04 , A61K51/0406 , C07B2200/05 , C07C211/41 , C07C211/42 , C07C307/02 , C07C2602/08 , C07D291/08
摘要： This invention relates to novel compounds suitable for labelling by 18F and the corresponding 18F labelled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).
摘要翻译： 本发明涉及适用于通过18F和相应的18F标记的化合物本身，相应的18F-氟化的类似物及其作为参考标准物的用途，制备这些化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂，及其用途 的这种化合物，用于通过正电子发射断层扫描（PET）进行诊断成像的组合物或试剂盒。
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3.发明申请COMPOUNDS FOR USE IN IMAGING, DIAGNOSING AND/OR TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM 有权用于成像，诊断和/或治疗中枢神经系统疾病的化合物公开(公告)号：US20130336890A1
公开(公告)日：2013-12-19
申请号：US13880847
申请日：2011-10-17
申请人： Andrea Thiele , Georg Kettschau , Tobias Heinrich , Lutz Lehmann , Christer Halldin , Sangram Nag , Andrea Varrone , Balazs Gulyas
发明人： Andrea Thiele , Georg Kettschau , Tobias Heinrich , Lutz Lehmann , Christer Halldin , Sangram Nag , Andrea Varrone , Balazs Gulyas
IPC分类号： C07C211/29 , A61K51/04
CPC分类号： A61K51/04 , C07B59/001 , C07C211/29
摘要： This invention relates to novel compounds suitable as precursors for the preparation of certain 18F labelled positron emission tomography (PET) tracers. Furthermore the invention relates to the preparation of such precursor molecules and to the preparation of PET tracers by 18F labelling of such precursors.
摘要翻译： 本发明涉及适用于制备某些18F标记的正电子发射断层扫描（PET）示踪剂的前体的新化合物。 此外，本发明涉及这种前体分子的制备以及通过对这些前体进行18F标记的PET示踪剂的制备。
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公开(公告)号：US08557776B2
公开(公告)日：2013-10-15
申请号：US11851910
申请日：2007-09-07
申请人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Tania Karramkam , Simon Ametamey
发明人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Tania Karramkam , Simon Ametamey
CPC分类号： C07K14/6555 , A61K51/088 , C07K14/57545
摘要： The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.
摘要翻译： 本发明涉及适用于或已经用18F放射性标记的新化合物，制备这种化合物的方法和用于诊断成像的这些化合物的用途。 这些标记的化合物由式II表征，其中取代基G，Q，L，Y和U具有如说明书和权利要求书中所定义的含义。
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公开(公告)号：US20110097269A1
公开(公告)日：2011-04-28
申请号：US12881224
申请日：2010-11-12
申请人： Lutz LEHMANN , Axel Rother
发明人： Lutz LEHMANN , Axel Rother
IPC分类号： A61K51/04 , C07C233/88 , C07C303/26 , C07C231/12 , A61K49/00 , C07D309/12 , C07F7/18 , B65D85/00
CPC分类号： C07D309/12 , A61K51/04 , C07C233/88 , C07C309/66 , C07C2601/14 , C07F7/1804
摘要： The present invention relates to phenyloxyaniline derivatives, to methods of their production and to uses thereof.
摘要翻译： 本发明涉及苯氧基苯胺衍生物，其制备方法及其应用。
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![[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION](/abs-image/US/2010/08/26/US20100217011A1/abs.jpg.150x150.jpg)
6.发明申请[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION 审中-公开[F-18] -L-氨基酸，[F-18] -L-谷氨酰胺，其衍生物及其用途及其制备方法公开(公告)号：US20100217011A1
公开(公告)日：2010-08-26
申请号：US12513112
申请日：2007-10-30
申请人： Ludger Dinkelborg , Matthias Friebe , Nikolaevna Raisa Krasikowa , Yuri Belokon , Fedorovna Olga Kuznetsova , Keith Graham , Lutz Lehmann , Mathias Berndt
发明人： Ludger Dinkelborg , Matthias Friebe , Nikolaevna Raisa Krasikowa , Yuri Belokon , Fedorovna Olga Kuznetsova , Keith Graham , Lutz Lehmann , Mathias Berndt
IPC分类号： C07F15/04 , C07D207/24 , C07D207/16 , C07C229/24 , C07C227/16
CPC分类号： A61K51/0402 , C07B59/001 , C07B2200/05 , C07C227/16 , C07C229/24 , C07C251/24 , C07C271/22 , C07C309/66 , C07C309/73 , C07D207/16 , C07D207/26 , C07D207/28 , C07F15/045
摘要： The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.
摘要翻译： 描述了[F-18]标记的L-谷氨酸[F-18] - 标记的L-谷氨酸酯，式（I）所示的衍生物及其用途的化合物和合成。
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公开(公告)号：US20150011773A1
公开(公告)日：2015-01-08
申请号：US14115471
申请日：2012-04-30
申请人： Mathias Berndt , Andre Muller , Heribert Schmitt-Willich , Timo Stellfeld , Georg Kettschau , Thomas Brumby , Keith Graham , Lutz Lehmann , Jorma Hassfeld , Martin Kruger
发明人： Mathias Berndt , Andre Muller , Heribert Schmitt-Willich , Timo Stellfeld , Georg Kettschau , Thomas Brumby , Keith Graham , Lutz Lehmann , Jorma Hassfeld , Martin Kruger
IPC分类号： C07D249/06 , C07D213/69 , C07C271/22 , C07C229/24 , C07D213/65 , C07C309/73
CPC分类号： C07D249/06 , A61K51/0406 , C07B59/00 , C07B2200/05 , C07C229/24 , C07C229/36 , C07C229/42 , C07C271/22 , C07C309/73 , C07C2601/04 , C07D213/55 , C07D213/61 , C07D213/65 , C07D213/69 , C07D319/06
摘要： This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).
摘要翻译： 本发明涉及适用于通过18F和相应的18F标记的化合物本身或其相应的18F-氟化的类似物进行标记的新化合物及其作为参考标准物的用途，制备此类化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒，以及 这些化合物，组合物或试剂盒用于通过正电子发射断层扫描（PET）进行诊断成像的用途。
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公开(公告)号：US20140150259A1
公开(公告)日：2014-06-05
申请号：US14128300
申请日：2012-06-18
申请人： Lutz Lehmann , Wolfgang Wimmer , Stefan Wimmer
发明人： Lutz Lehmann , Wolfgang Wimmer , Stefan Wimmer
IPC分类号： H01R43/01
CPC分类号： H01R43/01 , H01R4/203 , H01R4/2495 , H01R13/5205 , H01R43/0207 , Y10T29/49174
摘要： A method for assembling cables includes sliding a housing and a sleeve accommodated in the housing onto a cable in such a manner that the sleeve surrounds at least a portion of the cable. The housing is made of an electrically non-conductive material, the sleeve is made of an electrically conductive material and includes a cutting edge pointing radially inward, and the cable includes a conducting element and an insulation surrounding the conducting element. The method further includes magnetically forming the sleeve by applying a magnetic field to the sleeve through the housing, such that the sleeve is pressed against the insulation and the cutting edge penetrates the insulation completely and contacts the conducting element.
摘要翻译： 一种用于组装电缆的方法包括将容纳在壳体中的壳体和套筒滑动到电缆上，使得套筒围绕电缆的至少一部分。 壳体由不导电材料制成，套管由导电材料制成，并且包括径向向内指向的切割边缘，并且电缆包括导电元件和围绕导电元件的绝缘体。 该方法还包括通过通过壳体向套筒施加磁场来磁性地形成套筒，使得套筒被压靠在绝缘体上，并且切割刃完全穿透绝缘体并与导电元件接触。
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公开(公告)号：US20140134873A1
公开(公告)日：2014-05-15
申请号：US14128405
申请日：2012-06-18
申请人： Lutz Lehmann
发明人： Lutz Lehmann
CPC分类号： H01R4/20 , H01R4/2495 , H01R4/26 , H01R4/5083 , H01R9/03 , H01R43/0207 , H01R43/20 , Y10T29/49174
摘要： A line includes a cable, a sleeve, and a contact member. The cable includes a conductive member including a plurality of strands. The sleeve at least partially surrounds the strands. The contact member includes a core disposed between the strands and contacting with the strands, and a fastening portion at least partially surrounded by the sleeve. An outer surface of the fastening portion connects with an area of the sleeve.
摘要翻译： 线包括电缆，套筒和接触构件。 电缆包括包括多个绞线的导电构件。 套筒至少部分地包围股线。 接触构件包括设置在股线之间并与股线接触的芯部以及至少部分地被套筒包围的紧固部分。 紧固部的外表面与套筒的区域连接。
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10.发明申请Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic Acid and Derivatives Thereof, Process for their Production and Use for the Production of Pharmaceutical Agents 审中-公开对映体纯（4S，8S） - 和（4R，8R）-4-对硝基苄基-8-甲基-3,6,9-三氮杂-3 N，6N，9N-三羧甲基-1,11-十一烷二酸和衍生物 其生产和使用药剂的生产过程公开(公告)号：US20120064002A1
公开(公告)日：2012-03-15
申请号：US13076837
申请日：2011-03-31
IPC分类号： A61K51/00 , C07C229/28 , C07C331/28 , C07K16/00
CPC分类号： A61K51/1093 , A61K51/0497 , C07B2200/05 , C07B2200/07
摘要： Enantiomer-pure compounds of general formulas VIIa and VIIb in whichA stands for a group —COO—, and Z and R have different meanings, as well as use thereof are described.
摘要翻译： 对映体纯的通式VIIa和VIIb的化合物，其中A代表基团-COO-，Z和R具有不同的含义及其用途。
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