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公开(公告)号：US06528624B1
公开(公告)日：2003-03-04
申请号：US09282846
申请日：1999-03-31
IPC分类号： C12P2108
CPC分类号： C07K16/4291 , A61K38/00 , A61K47/6849 , A61K47/6873 , C07K16/00 , C07K16/22 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at one or more of amino acid positions 270, 322, 326, 327, 329, 331, 333 or 334 of the human IgG Fc region. Such variants display altered effector function. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be altered in the variant polypeptide. The application also discloses a variant of a parent polypeptide comprising a human IgG Fc region, which variant has a better binding affinity for human C1q than the parent polypeptide.
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公开(公告)号：US06194551B1
公开(公告)日：2001-02-27
申请号：US09282505
申请日：1999-03-31
IPC分类号： C07K1400
CPC分类号： C07K16/2896 , A61K47/6873 , C07K16/00 , C07K2317/21 , C07K2317/734
摘要： A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at amino acid position 329, or at two or all of amino acid positions 329, 331 and 322 of the human IgG Fc region. Such variants display altered effector function. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be reduced or abolished in the variant polypeptide. The application also describes an immune complex and an assay for determining binding of an analyte, such as an Fc region-containing polypeptide, to a receptor.
摘要翻译： 描述了包含人IgG Fc区的多肽的变体，该变体包含人IgG Fc区的氨基酸位置329或氨基酸位置329,331和322的氨基酸取代。 这些变体显示改变的效应子功能。 例如，可以在变体多肽中减少或消除C1q结合和/或补体依赖性细胞毒性（CDC）活性。 本申请还描述了免疫复合物和用于确定分析物（例如含Fc区域的多肽）与受体结合的测定法。
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公开(公告)号：US07741072B2
公开(公告)日：2010-06-22
申请号：US11871335
申请日：2007-10-12
CPC分类号： C07K16/4291 , A61K38/00 , A61K47/6849 , A61K47/6873 , C07K16/00 , C07K16/22 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at one or more of amino acid positions 270, 322, 326, 327, 329, 331, 333 or 334 of the human IgG Fc region. Such variants display altered effector function. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be altered in the variant polypeptide. The application also discloses a variant of a parent polypeptide comprising a human IgG Fc region, which variant has a better binding affinity for human C1q than the parent polypeptide.
摘要翻译： 描述了包含人IgG Fc区的多肽的变体，该变体包含人IgG Fc区的氨基酸位置270,322,326,327,329,331,333或334的氨基酸取代 。 这些变体显示改变的效应子功能。 例如，可以在变体多肽中改变C1q结合和/或补体依赖性细胞毒性（CDC）活性。 本申请还公开了包含人IgG Fc区的亲本多肽的变体，该变体与亲本多肽具有比人C1q更好的结合亲和力。
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公开(公告)号：US20080138338A1
公开(公告)日：2008-06-12
申请号：US11871335
申请日：2007-10-12
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , C12P21/04
CPC分类号： C07K16/4291 , A61K38/00 , A61K47/6849 , A61K47/6873 , C07K16/00 , C07K16/22 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at one or more of amino acid positions 270, 322, 326, 327, 329, 331, 333 or 334 of the human IgG Fc region. Such variants display altered effector function. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be altered in the variant polypeptide. The application also discloses a variant of a parent polypeptide comprising a human IgG Fc region, which variant has a better binding affinity for human C1q than the parent polypeptide.
摘要翻译： 描述了包含人IgG Fc区的多肽的变体，该变体包含人IgG Fc区的氨基酸位置270,322,326,327,329,331,333或334的氨基酸取代 。 这些变体显示改变的效应子功能。 例如，可以在变体多肽中改变C1q结合和/或补体依赖性细胞毒性（CDC）活性。 本申请还公开了包含人IgG Fc区的亲本多肽的变体，该变体与亲本多肽具有比人C1q更好的结合亲和力。
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公开(公告)号：US07364731B2
公开(公告)日：2008-04-29
申请号：US11429362
申请日：2006-05-05
IPC分类号： C07K16/00 , C12P21/08 , A61K39/40 , A61K39/395
CPC分类号： C07K16/4291 , A61K38/00 , A61K47/6849 , A61K47/6873 , C07K16/00 , C07K16/22 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at one or more of amino acid positions 270, 322, 326,327, 329, 331, 333 or 334 of the human IgG Fc region. Such variants display altered effector function. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be altered in the variant polypeptide. The application also discloses a variant of a parent polypeptide comprising a human IgG Fc region, which variant has a better binding affinity for human C1q than the parent polypeptide.
摘要翻译： 描述了包含人IgG Fc区的多肽的变体，该变体包含在人IgG Fc区的氨基酸位置270,322,326,327,329,331,333或334的一个或多个氨基酸取代。 这些变体显示改变的效应子功能。 例如，可以在变体多肽中改变C1q结合和/或补体依赖性细胞毒性（CDC）活性。 本申请还公开了包含人IgG Fc区的亲本多肽的变体，该变体与亲本多肽具有比人C1q更好的结合亲和力。
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公开(公告)号：US07297775B2
公开(公告)日：2007-11-20
申请号：US10292869
申请日：2002-11-12
CPC分类号： C07K16/4291 , A61K38/00 , A61K47/6849 , A61K47/6873 , C07K16/00 , C07K16/22 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at one or more of amino acid positions 270, 322, 326, 327, 329, 331, 333 or 334 of the human IgG Fc region. Such variants display altered effector function. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be altered in the variant polypeptide. The application also discloses a variant of a parent polypeptide comprising a human IgG Fc region, which variant has a better binding affinity for human C1q than the parent polypeptide.
摘要翻译： 描述了包含人IgG Fc区的多肽的变体，该变体包含人IgG Fc区的氨基酸位置270,322,326,327,329,331,333或334的氨基酸取代 。 这些变体显示改变的效应子功能。 例如，可以在变体多肽中改变C1q结合和/或补体依赖性细胞毒性（CDC）活性。 本申请还公开了包含人IgG Fc区的亲本多肽的变体，该变体与亲本多肽具有比人C1q更好的结合亲和力。
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公开(公告)号：US06538124B1
公开(公告)日：2003-03-25
申请号：US09680145
申请日：2000-10-03
IPC分类号： C07H2104
CPC分类号： C07K16/2896 , A61K47/6873 , C07K16/00 , C07K2317/21 , C07K2317/734
摘要： Isolated nucleic acid, vectors and host cells encoding antibody or immunoadhesin variants, as well as a process for producing the variants. The variants comprise a human IgG Fc region with amino acid substitution(s) therein, and display altered C1q binding function.
摘要翻译： 分离的核酸，载体和编码抗体或免疫粘附素变体的宿主细胞，以及产生变体的方法。 变体包含其中具有氨基酸取代的人IgG Fc区，并显示改变的C1q结合功能。
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公开(公告)号：US06242195B1
公开(公告)日：2001-06-05
申请号：US09054255
申请日：1998-04-02
申请人： Esohe Ekinaduese Idusogie , Michael George Mulkerrin , Leonard G. Presta , Robert Laird Shields
发明人： Esohe Ekinaduese Idusogie , Michael George Mulkerrin , Leonard G. Presta , Robert Laird Shields
IPC分类号： G01N3353
CPC分类号： C07K16/2896 , A61K38/00 , A61K47/6849 , A61K47/6873 , C07K16/22 , C07K16/4291 , C07K2317/71 , C07K2317/734 , C07K2319/00
摘要： A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at amino acid position 329, or at two or all of amino acid positions 329, 331 and 322 of the human IgG Fc region. Such variants display altered effector function. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be reduced or abolished in the variant polypeptide. The application also describes an immune complex and an assay for determining binding of an analyte, such as an Fc region-containing polypeptide, to a receptor.
摘要翻译： 描述了包含人IgG Fc区的多肽的变体，该变体包含人IgG Fc区的氨基酸位置329或氨基酸位置329,331和322的氨基酸取代。 这些变体显示改变的效应子功能。 例如，可以在变体多肽中减少或消除C1q结合和/或补体依赖性细胞毒性（CDC）活性。 本申请还描述了免疫复合物和用于确定分析物（例如含Fc区域的多肽）与受体结合的测定法。
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