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11 条记录 (耗时 0.036 秒)

    Syn isomers of cephalosporins having .alpha.-hydroximino- or .alpha.-acyloxyiminoacylamido groups at position-7
    4.
    发明授权
    Syn isomers of cephalosporins having .alpha.-hydroximino- or .alpha.-acyloxyiminoacylamido groups at position-7 失效
    在7-位上具有{60-羟肟基 - 或{6-氰酰氧基亚氨酰基酰胺基的头孢菌素的Syn异构体

    公开(公告)号：US4024134A

    公开(公告)日：1977-05-17

    申请号：US554014

    申请日：1975-02-28

    申请人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

    发明人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

    IPC分类号： C07C259/02 ,  C07D307/54 ,  C07D333/24 ,  C07D501/20

    CPC分类号： C07C259/02 ,  C07D307/54 ,  C07D333/24

    摘要： The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

    摘要翻译： 本发明提供了新的抗生素化合物，它们是7β-酰基酰胺基头孢-3-烯-4-羧酸及其无毒衍生物，和6β-酰基氨基青蒿素-3-羧酸及其无毒衍生物，其特征在于 酰胺基具有结构

    Penicillin antibiotics
    6.
    发明授权
    Penicillin antibiotics 失效
    青霉素抗生素

    公开(公告)号：US3991046A

    公开(公告)日：1976-11-09

    申请号：US612262

    申请日：1975-09-11

    申请人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

    发明人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

    IPC分类号： C07D307/54 ,  C07D333/24 ,  C07D499/68

    CPC分类号： C07D307/54 ,  C07D333/24

    摘要： The invention provides novel antibiotic compounds which are 6.beta.-acylamidopenam-3-carboxylic acids and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##EQU1## WHERE R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

    摘要翻译： 本发明提供了6β-酰基氨基青蒿素-3-羧酸及其无毒衍生物的新型抗生素化合物，其特征在于酰氨基具有结构R。 C 。 CONH PARALLEL NOROR R是氢原子或有机基团，R a是氢原子或酰基。 这些化合物是顺式异构体，或作为含有至少75％的顺式异构体的混合物存在。 这些抗生素化合物对革兰氏阳性和革兰氏阴性生物体的一系列革兰氏阴性菌具有很高的抗菌活性，与各种革兰氏阴性生物产生的β-内酰胺酶具有特别高的稳定性。 本发明还涉及化合物的给药。

    Cephalosporin antibiotics
    9.
    发明授权
    Cephalosporin antibiotics 失效
    头孢菌素类抗生素

    公开(公告)号：US4267320A

    公开(公告)日：1981-05-12

    申请号：US061260

    申请日：1979-07-27

    申请人： Michael Gregson ,  Richard B. Sykes

    发明人： Michael Gregson ,  Richard B. Sykes

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B57/00 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/30 ,  C07D501/34 ,  C07D501/60

    CPC分类号： C07D501/34

    摘要： The invention provides novel antibiotic cefuroxime esters of the formula ##STR1## (wherein R.sup.1 is a primary or secondary alkyl group containing 1 to 4 carbon atoms and R.sup.2 is a primary or secondary alkyl group containing 1 to 6 carbon atoms provided that at least one of the groups R.sup.1 and R.sup.2 is methyl). These compounds are useful as orally administrable broad spectrum antibiotics.

    摘要翻译： 本发明提供了新颖的式（IMAGE）抗生素头孢呋辛酯（其中R 1是含有1至4个碳原子的伯或仲烷基，R 2是含有1至6个碳原子的伯或仲烷基，条件是至少有一个 基团R 1和R 2是甲基）。 这些化合物可用作口服给药的广谱抗生素。

    Syn isomers of cephalosporins having .alpha.-hydroximino- or .alpha.-acyloxyiminoacylamido groups at position-7
    10.
    发明授权
    Syn isomers of cephalosporins having .alpha.-hydroximino- or .alpha.-acyloxyiminoacylamido groups at position-7 失效
    在7位具有α-羟肟基 - 或α-酰氧基亚氨基酰氨基的头孢菌素的同分异构体

    公开(公告)号：US4209616A

    公开(公告)日：1980-06-24

    申请号：US951761

    申请日：1978-10-16

    申请人： Michael Gregson ,  Martin C. Cook ,  Gordon I. Gregory

    发明人： Michael Gregson ,  Martin C. Cook ,  Gordon I. Gregory

    IPC分类号： C07C259/02 ,  C07D307/54 ,  C07D333/24 ,  C07D501/26 ,  C07D501/20

    CPC分类号： C07D307/54 ,  C07C259/02 ,  C07D333/24

    摘要： The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

    摘要翻译： 本发明提供了新的抗生素化合物，它们是7β-酰基酰胺基头孢-3-烯-4-羧酸及其无毒衍生物，和6β-酰基氨基青蒿素-3-羧酸及其无毒衍生物，其特征在于 酰胺基具有结构