公开(公告)号：US5252560A

公开(公告)日：1993-10-12

申请号：US905933

申请日：1992-06-29

申请人： Peter L. Myers ,  Andrew B. McElroy ,  Michael Gregson ,  Peter J. Brown ,  Howard G. Davies ,  David H. Drewry ,  Michael A. Foley

发明人： Peter L. Myers ,  Andrew B. McElroy ,  Michael Gregson ,  Peter J. Brown ,  Howard G. Davies ,  David H. Drewry ,  Michael A. Foley

IPC分类号： A61K38/55 ,  A61K38/00 ,  A61P1/02 ,  A61P17/00 ,  A61P19/10 ,  A61P25/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D209/48 ,  C07D209/66 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  A61K37/02 ,  C07D413/12

CPC分类号： C07K5/0222 ,  A61K38/00

摘要： Compounds are described of the formula ##STR1## wherein: R.sup.1 is C.sub.3-6 alkyl or C.sub.1-3 alkylthioC.sub.1-3 alkyl;R.sup.2 is an optionally substituted C.sub.1-6 alkyl or C.sub.1-6 alkoxy group, aryl, heteroaryl, arylC.sub.1-4 alkyl, heteroarylC.sub.1-4 alkyl or a side-chain of a natural .alpha.-amino acid;R.sup.3 is hydrogen, C.sub.1-6 alkyl, CHR.sup.4 COR.sup.5 (where R.sup.4 is a side-chain of a natural .alpha.-amino acid and R.sup.5 is hydroxyl, C.sub.1-6 alkoxy or NHR.sup.6 where R.sup.6 represents a hydrogen atom or a C.sub.1-6 alkyl group) or a group (CH.sub.2).sub.n X (where n is 1 to 6 and X is hydroxyl, C.sub.1-4 alkoxy, heteroaryl or a group NR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are each hydrogen or C.sub.1-6 alkyl or the group NR.sup.7 R.sup.8 forms a 5 to 7 membered cyclic amine); andHet is an optionally substituted cyclic imide where the cyclic imide ring system has the formula (i), (ii) or (iii) ##STR2## in which A, B, C and D are each CH or 1 or 2 of A, B, C and D represents N and the others represent CH, and E and F may each independently represent CH or N; and physiologically acceptable salts and solvates thereof.These compounds inhibit metalloproteases involved in tissue degradation. Compounds of the invention may be formulated for use in a variety of conditions involving tissue degradation including arthropathy, dermatological conditions, bone resorption, inflammatory diseases, tumour invasion and multiple sclerosis and related diseases involving myelin degradation, and in the promotion of wound healing.

公开(公告)号：US5326760A

公开(公告)日：1994-07-05

申请号：US31439

申请日：1993-03-15

申请人： Andrew B. McElroy ,  Peter J. Brown ,  David H. Drewry ,  James M. Salovich ,  Frank J. Schoenen

发明人： Andrew B. McElroy ,  Peter J. Brown ,  David H. Drewry ,  James M. Salovich ,  Frank J. Schoenen

IPC分类号： C07C237/06 ,  C07D209/48 ,  C07D209/66 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D487/04 ,  C07F7/18 ,  A61K31/395 ,  A61K31/40

CPC分类号： C07D209/48 ,  C07C237/06 ,  C07D209/66 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D487/04 ,  C07F7/1852 ,  C07F7/1856

摘要： Aminobutanoic acids of the following formula (I): ##STR1## where R.sup.1 -R.sup.5 are a variety of substituents, novel intermediates, a pharmaceutical composition for treating inflammatory diseases, demyelinating diseases, and tumor metastasis, methods for such treatment and processes for preparing compounds of formula (I).

摘要翻译： 下式（I）的氨基丁酸：其中R1-R5是多种取代基，新型中间体，用于治疗炎性疾病，脱髓鞘疾病和肿瘤转移的药物组合物，其用于治疗和治疗的方法 用于制备式（I）的化合物。

公开(公告)号：US4898949A

公开(公告)日：1990-02-06

申请号：US151512

申请日：1988-02-18

申请人： John J. Wright ,  Sing-Yuen Sit ,  Neelakantan Balasubramanian ,  Peter J. Brown

发明人： John J. Wright ,  Sing-Yuen Sit ,  Neelakantan Balasubramanian ,  Peter J. Brown

IPC分类号： A61K31/41 ,  A61P3/06 ,  C02F11/00 ,  C07D257/04 ,  C07D405/06 ,  C07F9/6524

CPC分类号： C07D257/04 ,  C07D405/06 ,  C07F9/6524

摘要： This invention provides novel tetrazole intermediates of the formula ##STR1## wherein R.sup.1 and R.sup.4 each are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl;R.sup.2,R.sup.3,R.sup.5 and R.sup.6 each are independently hydrogen, halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy;B is hydrogen, C.sub.1-4 alkoxycarbonyl, CH.sub.2 Y or CH.sub.2 Z;Y is hydrogen, hydroxyl or X;Z is ##STR2## X is bromo, chloro or iodo; R.sup.10 is C.sub.1-4 alkyl; andR.sup.11 is phenyl which is unsubstituted or substituted by one or two C.sub.1-4 alkyl or chloro substituents.and processes thereof which are useful for the preparation of antihypercholesterolemic agents.

摘要翻译： 本发明提供了式（Ia）的新型四唑中间体，其中R 1和R 4各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基或三氟甲基; R2，R3，R5和R6各自独立地为氢，卤素，C1-4烷基或C1-4烷氧基; B是氢，C 1-4烷氧基羰基，CH 2 Y或CH 2 Z; Y是氢，羟基或X; Z是X，Y是溴，氯或碘; R 10是C 1-4烷基; 并且R 11是未被取代或被一个或两个C 1-4烷基或氯取代基取代的苯基。 及其制备抗高胆固醇血症药物的方法。

公开(公告)号：US06799225B2

公开(公告)日：2004-09-28

申请号：US09778511

申请日：2001-02-06

申请人： G. Byron Sands ,  Peter J. Brown ,  Don A. Dykes ,  Andrew L. Love ,  Kevin W. Eyres

发明人： G. Byron Sands ,  Peter J. Brown ,  Don A. Dykes ,  Andrew L. Love ,  Kevin W. Eyres

IPC分类号： G06F1314

CPC分类号： G06F13/105

摘要： A computer system implements a standard modem without the use of a microcontroller. Instead, a digital signal processor is provided on an expansion card, but with direct links to the computer system itself. The code usually implemented in the microcontroller is instead implemented as a virtual modem controller to be called by the operating system of the computer itself. Further, this virtual modem controller includes a virtualized UART, that appears to the operating system software as a hardware UART, with entry points for calls to replace input/output instructions. In this way, standard device driver code written to execute input/output operations is easily converted to operate with the “virtualized” UART.

摘要翻译： 计算机系统在不使用微控制器的情况下实现标准调制解调器。 相反，在扩展卡上提供数字信号处理器，而是直接连接到计算机系统本身。 通常在微控制器中实现的代码被实现为由计算机本身的操作系统调用的虚拟调制解调器控制器。 此外，该虚拟调制解调器控制器包括虚拟化UART，其作为硬件UART在操作系统软件中出现，具有用于替换输入/输出指令的调用的入口点。 以这种方式，写入执行输入/输出操作的标准设备驱动程序代码很容易转换为使用“虚拟化”UART进行操作。

公开(公告)号：US5089948A

公开(公告)日：1992-02-18

申请号：US546117

申请日：1990-06-29

申请人： Peter J. Brown ,  Suresh Hariharan

发明人： Peter J. Brown ,  Suresh Hariharan

IPC分类号： H03K17/795

CPC分类号： H03K17/7955 ,  Y10S323/902

摘要： An electrically isolated high speed optical switching arrangement for use as a computer over-voltage sensing circuit utilizing first and second optoisolator devices, the first having an input, a first signal from the output of a bus sensing circuitry which provides two complementary outputs, with the output voltage of the optoisolator controlling power-down circuitry for the computer in response to an over-voltage condition. A second control optoisolator has its output in parallel with a resistor in the base to emitter path of the first optoisolator. The complementary signal of the bus-sensing circuitry provides the input to the second optoisolator. During normal power conditions, the first optoisolator is conductive and the second is non-conductive. As an over-voltage condition occurs, the second optoisolator is driven into conduction, thereby effectively providing a shunt across the resistor of the first optoisolator while the first optoisolator is shut off to instantaneously terminate conduction of the first optoisolator and provide an output signal to the power-down circuitry for shutting down the power in response to the over-voltage condition.

摘要翻译： 一种电隔离的高速光开关装置，用作利用第一和第二光隔离器装置的计算机过电压感测电路，第一和第二光隔离器装置具有输入，来自总线感测电路的输出的第一信号，其提供两个互补输出， 响应于过电压条件，计算机的控制断电电路的光隔离器的输出电压。 第二控制光隔离器的输出与第一光隔离器的基极到发射极路径中的电阻并联。 总线感测电路的互补信号为第二光隔离器提供输入。 在正常功率条件下，第一个光隔离器是导电的，第二个是非导通的。 当发生过电压状态时，第二光隔离器被驱动导通，由此有效地在第一光隔离器的电阻器之间提供并联，同时第一光隔离器被切断以瞬时终止第一光隔离器的导通，并向第一光隔离器提供输出信号 断电电路，用于响应过电压条件关闭电源。

公开(公告)号：US06779064B2

公开(公告)日：2004-08-17

申请号：US10057404

申请日：2002-01-24

申请人： Michael E. McGowen ,  William C. Edwards ,  Peter J. Brown ,  Craig M. Belusar

发明人： Michael E. McGowen ,  William C. Edwards ,  Peter J. Brown ,  Craig M. Belusar

IPC分类号： G06F1300

CPC分类号： H04L67/1097 ,  G06F3/0601 ,  G06F9/4411 ,  G06F11/2005 ,  G06F11/2007 ,  G06F11/2092 ,  G06F2003/0692

摘要： A system and method for enabling multi-path functionality between a host bus adapter (HBA) in a host computer of a storage system and at least one storage device is disclosed. The host computer includes a processor and associated memory, and an operating system including a PnP manager that maintains a logical device stack for the storage device. An HBA-specific filter driver intercepts responses from the underlying HBA driver to specified PnP requests. These responses are modified to prevent standard Microsoft operating system SCSI class device drivers from being loaded for devices attached to the HBA. Instead, the modified responses cause a multi-path SCSI class device driver to be loaded. The filter driver also monitors the status of the paths to a device and, upon request, provides status information to the multi-path SCSI class device driver. The multi-path SCSI class driver may use this status information to decide whether to make a particular path a primary path. The actions required to make a path a primary path may be performed by the filter driver, e.g., through a function call to the filter driver initiated by the multi-path SCSI driver.

摘要翻译： 公开了一种用于在存储系统的主计算机中的主机总线适配器（HBA）和至少一个存储设备之间实现多路径功能的系统和方法。 主机包括处理器和相关联的存储器，以及包括维护存储设备的逻辑设备堆栈的PnP管理器的操作系统。 HBA特定的过滤器驱动程序拦截从基础HBA驱动程序到指定的PnP请求的响应。 修改这些响应以防止为连接到HBA的设备加载标准的Microsoft操作系统SCSI类设备驱动程序。 相反，修改的响应会导致加载多路径SCSI类设备驱动程序。 过滤器驱动程序还监视设备路径的状态，并根据请求向多路径SCSI类设备驱动程序提供状态信息。 多路径SCSI类驱动程序可以使用该状态信息来决定是否使特定路径成为主路径。 使路径成为主路径所需的动作可以由过滤器驱动器执行，例如通过对由多路径SCSI驱动器发起的过滤器驱动程序的函数调用来执行。

公开(公告)号：US5864710A

公开(公告)日：1999-01-26

申请号：US685310

申请日：1996-07-22

申请人： G. Byron Sands ,  Peter J. Brown ,  Don A. Dykes ,  Andrew L. Love ,  Kevin W. Eyres

发明人： G. Byron Sands ,  Peter J. Brown ,  Don A. Dykes ,  Andrew L. Love ,  Kevin W. Eyres

IPC分类号： G06F13/10 ,  G06F13/00

CPC分类号： G06F13/105

摘要： A computer system implements a standard modem without the use of a microcontroller. Instead, a digital signal processor is provided on an expansion card, but with direct links to the computer system itself. The code usually implemented in the microcontroller is instead implemented as a virtual modem controller to be called by the operating system of the computer itself. Further, this virtual modem controller includes a virtualized UART, that appears to the operating system software as a hardware UART, with entry points for calls to replace input/output instructions. In this way, standard device driver code written to execute input/output operations is easily converted to operate with the "virtualized" UART.

摘要翻译： 计算机系统在不使用微控制器的情况下实现标准调制解调器。 相反，在扩展卡上提供数字信号处理器，而是直接连接到计算机系统本身。 通常在微控制器中实现的代码被实现为由计算机本身的操作系统调用的虚拟调制解调器控制器。 此外，该虚拟调制解调器控制器包括虚拟化UART，其作为硬件UART在操作系统软件中出现，具有用于替换输入/输出指令的调用的入口点。 以这种方式，写入执行输入/输出操作的标准设备驱动程序代码很容易转换为使用“虚拟化”UART进行操作。

公开(公告)号：US06185628B2

公开(公告)日：2001-02-06

申请号：US09237636

申请日：1999-01-26

申请人： G. Byron Sands ,  Peter J. Brown ,  Don A. Dykes ,  Andrew L. Love ,  Kevin W. Eyres

发明人： G. Byron Sands ,  Peter J. Brown ,  Don A. Dykes ,  Andrew L. Love ,  Kevin W. Eyres

IPC分类号： G06F300

CPC分类号： G06F13/105

摘要： A computer system implements a standard modem without the use of a microcontroller. Instead, a digital signal processor is provided on an expansion card, but with direct links to the computer system itself. The code usually implemented in the microcontroller is instead implemented as a virtual modem controller to be called by the operating system of the computer itself. Further, this virtual modem controller includes a virtualized UART, that appears to the operating system software as a hardware UART, with entry points for calls to replace input/output instructions. In this way, standard device driver code written to execute input/output operations is easily converted to operate with the “virtualized” UART.

摘要翻译： 计算机系统在不使用微控制器的情况下实现标准调制解调器。 相反，在扩展卡上提供数字信号处理器，而是直接连接到计算机系统本身。 通常在微控制器中实现的代码被实现为由计算机本身的操作系统调用的虚拟调制解调器控制器。 此外，该虚拟调制解调器控制器包括虚拟化UART，其作为硬件UART在操作系统软件中出现，具有用于替换输入/输出指令的调用的入口点。 以这种方式，写入执行输入/输出操作的标准设备驱动程序代码很容易转换为使用“虚拟化”UART进行操作。

公开(公告)号：US6112260A

公开(公告)日：2000-08-29

申请号：US791590

申请日：1997-01-31

申请人： Arnold R. Colterjohn ,  Peter J. Brown ,  Douglas E. Stewart

发明人： Arnold R. Colterjohn ,  Peter J. Brown ,  Douglas E. Stewart

IPC分类号： G06F13/10 ,  G06F7/02 ,  G06F13/14

CPC分类号： G06F13/105

摘要： A computer system implements a standard modem without the use of a microcontroller. Instead, a digital signal processor is provided on an expansion card, but with direct links to the computer system itself. The code usually implemented in the microcontroller is instead implemented as a virtual modem controller to be called by the operating system of the computer itself. Further, this virtual modem controller includes a virtualized UART, that appears to the operating system software as a hardware UART, and the operating system driver software need not even have its input and output instructions replaced. Instead, debug registers are provided as breakpoints whenever an input/output instruction is executed to the I/O port range at which the UART would normally appear.

摘要翻译： 计算机系统在不使用微控制器的情况下实现标准调制解调器。 相反，在扩展卡上提供数字信号处理器，而是直接连接到计算机系统本身。 通常在微控制器中实现的代码被实现为由计算机本身的操作系统调用的虚拟调制解调器控制器。 此外，该虚拟调制解调器控制器包括虚拟化UART，其作为硬件UART在操作系统软件中出现，并且操作系统驱动器软件甚至不需要更换其输入和输出指令。 相反，每当对UART通常出现的I / O端口范围执行输入/输出指令时，调试寄存器就被提供为断点。

公开(公告)号：US4269605A

公开(公告)日：1981-05-26

申请号：US52474

申请日：1979-06-27

申请人： Peter D. G. Dean ,  Peter J. Brown ,  Vasilis Bouriotis

发明人： Peter D. G. Dean ,  Peter J. Brown ,  Vasilis Bouriotis

IPC分类号： C07K14/47 ,  C07K14/805 ,  G01N33/72 ,  G01N33/66

CPC分类号： C07K14/805 ,  C07K14/47 ,  G01N33/723 ,  Y10S530/816

摘要： Glycoproteins, especially glycosylated hemoglobins, are separated from non-glycosylated proteins, by complexing with a dihydroxyboryl reactive agent. The resulting complex can be separated physically from the non-glycosylated protein, making possible the determination of glycosylated hemoglobin content of lysed blood; a reactive agent and a kit are described for use in such determination and as a monitor in the control of diabetic treatment. The invention can also be used preparatively to isolate glycoproteins.

摘要翻译： 通过与二羟基硼烷反应剂络合，糖蛋白，特别是糖基化血红蛋白与非糖基化蛋白质分离。 所得到的复合物可以与非糖基化蛋白物理分离，使得裂解血液中糖基化血红蛋白含量的测定成为可能; 描述了用于这种测定的反应剂和试剂盒以及用于控制糖尿病治疗的监测器。 本发明也可以制备性地用于分离糖蛋白。