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    Circulation active 4-aminoaryldihydropryidine lactones
    1.
    发明授权
    Circulation active 4-aminoaryldihydropryidine lactones 失效
    循环活性4-氨基芳基二氢化丙酸内酯

    公开(公告)号：US5162338A

    公开(公告)日：1992-11-10

    申请号：US782748

    申请日：1991-10-18

    申请人： Siegfried Goldmann ,  Matthias Schramm ,  Rainer Gross ,  Gunther Thomas ,  Martin Bechem ,  Michael Kayser

    发明人： Siegfried Goldmann ,  Matthias Schramm ,  Rainer Gross ,  Gunther Thomas ,  Martin Bechem ,  Michael Kayser

    IPC分类号： C07D491/04 ,  C07D491/048

    CPC分类号： C07D491/04

    摘要： 4 Aminoaryldihydropyridines of the formula ##STR1## in which R.sup.1 is hydrogen or an organic radical, preferably methyl or ethyl,R.sup.2 is hydrogen, C.sub.1 -C.sub.5 - alkyl, --CN, --NH.sub.2, --CH.sub.2 or --CH.sub.2 OH, preferably methyl,R.sup.3 is hydrogen or alkyl, preferably hydrogen,Y is --CO-- or --SO.sub.2 --, andR.sup.4 is an organic radical, orY-R.sup.4 is hydrogen,and physiologically acceptable salts thereof, are circulation-active and effective for improving myocardial contractility, for raising blood pressure, for lowering blood sugar, for reducing mucosal swelling and for controlling the salt and fluid balance.

    摘要翻译： 4，其中R 1是氢或有机基团，优选甲基或乙基的氨基芳基二氢吡啶，其中R 2是氢，C 1 -C 5 - 烷基，-CN，-NH 2，-CH 2或-CH 2 OH，优选甲基，R 3是 氢或烷基，优选氢，Y是-CO-或-SO 2 - ，并且R 4是有机基团，或Y-R 4是氢，并且其生理上可接受的盐是循环活性的并且对于提高心肌收缩力是有效的，用于提高 血压降低血糖，减少粘膜肿胀和控制盐和液体平衡。

    Circulation-active substituted 5-nitro-1,4-dihydropyridines
    2.
    发明授权
    Circulation-active substituted 5-nitro-1,4-dihydropyridines 失效
    循环活性取代的5-硝基-1,4-二氢吡啶

    公开(公告)号：US4876254A

    公开(公告)日：1989-10-24

    申请号：US179102

    申请日：1988-04-08

    申请人： Gerhard Franckowiak ,  Michael Kayser ,  Matthias Schramm ,  Gunther Thomas ,  Rainer Gross ,  elisabeth Perzborn ,  Friedel Seuter

    发明人： Gerhard Franckowiak ,  Michael Kayser ,  Matthias Schramm ,  Gunther Thomas ,  Rainer Gross ,  elisabeth Perzborn ,  Friedel Seuter

    IPC分类号： A61K31/50 ,  A61K31/505 ,  A61P9/00 ,  C07D211/90 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    CPC分类号： C07D401/12 ,  C07D211/90 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

    摘要： For the treatment of circulation disorders, the novel 5-nitro-1,4-dihydropyridines of the formula ##STR1## in which R represents C.sub.6 -C.sub.14 -aryl which can be mono- to pentasubstituted by identical or different substituents from the series comprising halogen, nitro, cyano, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, trifluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylthio and benzyl, benzyloxy or benzylthio optionally substituted by nitro, cyano, trifluoromethyl, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, orrepresents a heterocycle from the series pyrryl, thienyl, furyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidyl, quinolyl, benzoxadiazolyl, chromenyl or thiochromenyl optionally mono- to tetrasubstituted by halogen, phenyl or C.sub.1 -C.sub.4 -alkyl orrepresents straight-chain, branched or cyclic alkyl with up to 14 carbon atoms,and their physiologically acceptable salts.

    摘要翻译： 对于循环障碍的治疗，式“IMAGE”的新的5-硝基-1,4-二氢吡啶类，其中R代表C6-C14-芳基，其可以由包含卤素的系列的相同或不同的取代基单取代或五取代 硝基，氰基，C 1 -C 6烷基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷硫基，三氟甲基，三氟甲氧基，二氟甲氧基，三氟甲硫基和苄基，任选被硝基，氰基， 或C 1 -C 4 - 烷氧基，或代表吡啶基，噻吩基，呋喃基，吡唑基，咪唑基，恶唑基，噻唑基，吡啶基，哒嗪基，嘧啶基，喹啉基，苯并二唑基， 被卤素，苯基或C 1 -C 4烷基四取代，或代表具有至多14个碳原子的直链，支链或环状烷基，及其生理上可接受的盐。

    [4-(6-Oxo-1,4,5,6-tetrahydro-3-pyridazinyl) anilino hexyl 1,4-dihydro-2,6 Di methyl 5 nitro 4 aryl pyridine 3-carboxylates
    8.
    发明授权
    [4-(6-Oxo-1,4,5,6-tetrahydro-3-pyridazinyl) anilino hexyl 1,4-dihydro-2,6 Di methyl 5 nitro 4 aryl pyridine 3-carboxylates 失效
    [4-（6-氧代-1,4,5,6-四氢-3-哒嗪基）苯胺基己基1,4-二氢-2,6-二甲基-5-硝基4芳基吡啶3-羧酸酯

    公开(公告)号：US4898865A

    公开(公告)日：1990-02-06

    申请号：US218759

    申请日：1988-07-13

    申请人： Gerhard Franckowiak ,  Martin Bechem ,  Michael Kayser ,  Rainer Gross ,  Matthias Schramm ,  Friedel Seuter ,  Elisabeth Perzborn ,  Gunther Thomas

    发明人： Gerhard Franckowiak ,  Martin Bechem ,  Michael Kayser ,  Rainer Gross ,  Matthias Schramm ,  Friedel Seuter ,  Elisabeth Perzborn ,  Gunther Thomas

    IPC分类号： A61K31/50 ,  A61P3/00 ,  A61P3/08 ,  A61P9/00 ,  C07D237/04 ,  C07D401/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    CPC分类号： C07D401/12 ,  C07D237/04

    摘要： Circulation active nitrodihydropyridines of the formula ##STR1## in which R represents aryl which has 6 to 12 carbon atoms and can be substituted up to 4 times, identically or differently, by halogen, nitro, cyano, alkyl, alkoxy, alkylthio, in each case having up to 6 carbon atoms, trifluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylthio, difluoromethylenedioxy, trifluoroethylenedioxy or tetrafluoroethylenedioxy or by benzyl, benzyloxy or benzylthio, each of which is optionally substituted by halogen, nitro, cyano, trifuoromethyl, alkyl having up to 4 carbon atoms or alkoxy having up to 4 carbon atoms, or represents a heterocycle which is optionally substituted by halogen, phenyl or alkyl having up to 4 carbon atoms and is from the group consisting of pyrryl, thienyl, furyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, pyridyl, pyrimidyl, pyridazinyl, quinolyl, benzoxadiazolyl, chromenyl or thiochromenyl, andn represents a number from 1 to 12,and physiologically acceptable salts thereof.

    摘要翻译： 具有式“IMAGE”的循环活性硝基二氢吡啶，其中R表示具有6至12个碳原子并且可以相同或不同地被卤素，硝基，氰基，烷基，烷氧基，烷硫基取代至多4次的芳基， 具有至多6个碳原子，三氟甲基，三氟甲氧基，二氟甲氧基，三氟甲硫基，二氟亚甲二氧基，三氟亚乙二氧基或四氟亚乙二氧基或苄基，苄氧基或苄硫基，其各自任选被卤素，硝基，氰基，三氟甲基，具有至多4个碳原子的烷基 或具有至多4个碳原子的烷氧基，或表示任选被卤素，苯基或具有至多4个碳原子的烷基取代的杂环，并且是由吡咯基，噻吩基，呋喃基，吡唑基，咪唑基，恶唑基，噻唑基， 吡啶基，嘧啶基，哒嗪基，喹啉基，苯并二唑基，苯并二唑基，色烯基或硫代色烯基，n表示1〜12的数，生理学上可接受的 其盐。