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1.发明申请公开(公告)号：US20120022166A1
公开(公告)日：2012-01-26
申请号：US13190269
申请日：2011-07-25
申请人： Michael S. McGrath
发明人： Michael S. McGrath
IPC分类号： A61K31/155 , A61P13/12 , A61P9/10
CPC分类号： G01N33/56972 , A61K31/13 , A61K31/131 , A61K31/155 , G01N33/5055 , G01N33/6896 , G01N2800/2821
摘要： Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.
摘要翻译： 提供了在巨噬细胞相关疾病患病或有风险的个体中调节巨噬细胞增殖的方法。 该方法采用多胺类似物，或其盐或被保护的衍生物。 巨噬细胞增殖已涉及许多严重疾病，包括艾滋病（HIV）相关性痴呆，艾滋病相关性非霍奇金淋巴瘤和阿尔茨海默病。 本发明还提供了帮助诊断和监测与巨噬细胞相关的非HIV相关性痴呆，特别是阿尔茨海默病的治疗的方法。 本发明还提供了延迟巨噬细胞相关非HIV相关性痴呆（包括阿尔茨海默病）发展的方法，其需要施用调节巨噬细胞增殖的药剂。
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公开(公告)号：US20110053186A1
公开(公告)日：2011-03-03
申请号：US12900361
申请日：2010-10-07
申请人： Michael S. McGrath
发明人： Michael S. McGrath
IPC分类号： G01N33/53
CPC分类号： A61K33/20 , A61K9/0019 , A61K33/00 , A61K33/40 , A61K47/02 , Y10S514/879 , Y10S514/885
摘要： The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy.
摘要翻译： 本发明的特征在于通过施用有效降低血液免疫细胞活化的量的亚氯酸盐来治疗受试者中巨噬细胞相关神经变性疾病如肌萎缩性侧索硬化（ALS），阿尔茨海默病（AD）或多发性硬化症（MS）的方法。 本发明还具有通过评估治疗前后的免疫细胞活化来监测治疗的方法。
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3.发明授权公开(公告)号：US07087648B1
公开(公告)日：2006-08-08
申请号：US09179383
申请日：1998-10-26
申请人： Michael S. McGrath
发明人： Michael S. McGrath
IPC分类号： A61K31/13 , A61K31/655
CPC分类号： G01N33/56972 , A61K31/13 , A61K31/131 , A61K31/155 , G01N33/5055 , G01N33/6896 , G01N2800/2821
摘要： Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.
摘要翻译： 提供了在巨噬细胞相关疾病患病或有风险的个体中调节巨噬细胞增殖的方法。 该方法采用多胺类似物，或其盐或被保护的衍生物。 巨噬细胞增殖已涉及许多严重疾病，包括艾滋病（HIV）相关性痴呆，艾滋病相关性非霍奇金淋巴瘤和阿尔茨海默病。 本发明还提供了帮助诊断和监测与巨噬细胞相关的非HIV相关性痴呆，特别是阿尔茨海默病的治疗的方法。 本发明还提供了延迟巨噬细胞相关非HIV相关性痴呆（包括阿尔茨海默病）发展的方法，其需要施用调节巨噬细胞增殖的药剂。
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4.发明授权公开(公告)号：US06537523B1
公开(公告)日：2003-03-25
申请号：US08975532
申请日：1997-11-20
IPC分类号： A61K4900
CPC分类号： C12Q1/703 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/5055 , Y10S435/81
摘要： The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
摘要翻译： 前癌和癌组织中克隆巨噬细胞的存在代表了由于HIV整合或其他遗传突变而发生巨噬细胞的克隆扩张的疾病的早期阶段。 克隆扩张的巨噬细胞诱导周围组织的增殖导致癌性肿瘤生长。 本发明提供用于诊断前癌和癌组织中巨噬细胞的HIV和非HIV相关克隆扩增的方法和试剂盒。 本发明还提供了治疗由克隆巨噬细胞扩增和周围组织的增殖诱导的癌症的方法。
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公开(公告)号：US5580715A
公开(公告)日：1996-12-03
申请号：US286745
申请日：1994-08-05
CPC分类号： C12Q1/703 , C12Q1/6886 , G01N33/5055 , C12Q2600/112 , C12Q2600/136 , Y10S435/81
摘要： The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.
摘要翻译： 前癌和癌组织中克隆巨噬细胞的存在代表了由于HIV整合或其他遗传突变而发生巨噬细胞的克隆扩张的疾病的早期阶段。 克隆扩张的巨噬细胞诱导周围组织的增殖导致癌性肿瘤生长。 本发明提供用于诊断前癌和癌组织中巨噬细胞的HIV和非HIV相关克隆扩增的方法和试剂盒。 本发明还提供了治疗由克隆巨噬细胞扩增和周围组织的增殖诱导的癌症的方法。
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公开(公告)号：US08029826B2
公开(公告)日：2011-10-04
申请号：US11378987
申请日：2006-03-17
申请人： Michael S. McGrath
发明人： Michael S. McGrath
CPC分类号： A61K33/20 , A61K9/0019 , A61K33/00 , A61K33/40 , A61K47/02 , Y10S514/879 , Y10S514/885
摘要： The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy.
摘要翻译： 本发明的特征在于通过施用有效降低血液免疫细胞活化的量的亚氯酸盐来治疗受试者中巨噬细胞相关神经变性疾病如肌萎缩性侧索硬化（ALS），阿尔茨海默病（AD）或多发性硬化症（MS）的方法。 本发明还具有通过评估治疗前后的免疫细胞活化来监测治疗的方法。
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7.发明授权公开(公告)号：US08008353B2
公开(公告)日：2011-08-30
申请号：US11022153
申请日：2004-12-22
申请人： Michael S. McGrath
发明人： Michael S. McGrath
IPC分类号： A61K31/155
CPC分类号： G01N33/56972 , A61K31/13 , A61K31/131 , A61K31/155 , G01N33/5055 , G01N33/6896 , G01N2800/2821
摘要： Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.
摘要翻译： 提供了在巨噬细胞相关疾病患病或有风险的个体中调节巨噬细胞增殖的方法。 该方法采用多胺类似物，或其盐或被保护的衍生物。 巨噬细胞增殖已涉及许多严重疾病，包括艾滋病（HIV）相关性痴呆，艾滋病相关性非霍奇金淋巴瘤和阿尔茨海默病。 本发明还提供了帮助诊断和监测与巨噬细胞相关的非HIV相关性痴呆，特别是阿尔茨海默病的治疗的方法。 本发明还提供了延迟巨噬细胞相关非HIV相关性痴呆（包括阿尔茨海默病）发展的方法，其需要施用调节巨噬细胞增殖的药剂。
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公开(公告)号：US20110091418A1
公开(公告)日：2011-04-21
申请号：US12974126
申请日：2010-12-21
IPC分类号： A61K38/20 , A61K31/155 , A61K31/132 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/513 , A61K31/655 , A61K31/4439 , A61K31/427 , A61K39/395 , A61K38/19 , A61P31/12 , A61P31/18
CPC分类号： A61K31/13 , A61K31/155 , A61K45/06 , A61K2300/00
摘要： Methods for treating viral infections using polyamine analogs, including mitoguazone (MGBG), are provided. In these methods, polyamine analogs destroy macrophages that act as viral reservoirs, facilitating the destruction of the viruses that dwell within the macrophages. Examples of viral infections that may be treated with the present methods include, but are not limited to, infections from human immunodeficiency viruses. These methods differ from previous methods of treatment using polyamine analogs, wherein the polyamine analogs were administered only as anti-tumor agents.
摘要翻译： 提供了使用多胺类似物（包括丝裂霉素（MGBG））治疗病毒感染的方法。 在这些方法中，多胺类似物破坏充当病毒储库的巨噬细胞，有助于破坏巨噬细胞内的病毒。 可以用本发明方法治疗的病毒感染的实例包括但不限于人免疫缺陷病毒的感染。 这些方法与先前使用多胺类似物的治疗方法不同，其中多胺类似物仅作为抗肿瘤剂施用。
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公开(公告)号：US07105183B2
公开(公告)日：2006-09-12
申请号：US11042816
申请日：2005-01-24
申请人： Michael S. McGrath
发明人： Michael S. McGrath
CPC分类号： A61K33/20 , A61K9/0019 , A61K33/00 , A61K33/40 , A61K47/02 , Y10S514/879 , Y10S514/885
摘要： The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy.
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公开(公告)号：US6149918A
公开(公告)日：2000-11-21
申请号：US529881
申请日：1995-09-18
IPC分类号： A61K39/245 , C07K16/08 , C12N7/00 , A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K39/245 , C07K16/085 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , C12N2710/16021 , C12N2710/16034 , C12N2710/16434
摘要： A human lymphoma cell line containing a human herpesvirus type 8 (HHV-8) capable of in vitro growth and which produces HHV-8 virus particles upon induction of lytic viral growth is provided. Virus produced by the cell line of the invention is useful for the production of antibodies to an HHV-8 virus particle, viral protein, or viral peptide. Methods of screening a biological sample for the presence of HHV-8 virus particles, viral protein, or viral peptide from a human suspected of being infected with HHV-8 are provided as are methods of screening a biological sample of the human for antibodies to HHV-8.
摘要翻译： 提供了含有能够体外生长并在诱导溶解病毒生长时产生HHV-8病毒颗粒的人疱疹病毒8型（HHV-8）的人类淋巴瘤细胞系。 由本发明的细胞系产生的病毒可用于产生针对HHV-8病毒颗粒，病毒蛋白或病毒肽的抗体。 提供了从怀疑被HHV-8感染的人中筛选生物样品中存在HHV-8病毒颗粒，病毒蛋白或病毒肽的方法，例如筛选人的生物学样品用于HHV抗体的方法 -8。
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