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公开(公告)号：US07432364B2
公开(公告)日：2008-10-07
申请号：US11504527
申请日：2006-08-14
申请人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US20070160614A1
公开(公告)日：2007-07-12
申请号：US11504527
申请日：2006-08-14
申请人： Clark Pan , Andreas Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/40
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US06750202B1
公开(公告)日：2004-06-15
申请号：US09830741
申请日：2001-06-21
IPC分类号： C07K506
摘要： The invention relates to a method of treating a fibrotic disease, comprising administering to a mammal an effective amount of a phospinate-peptide analog of the general formula (I).
摘要翻译： 本发明涉及一种治疗纤维化疾病的方法，包括向哺乳动物施用有效量的通式（I）的磷酸 - 肽类似物。
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公开(公告)号：US20110262429A1
公开(公告)日：2011-10-27
申请号：US13174510
申请日：2011-06-30
申请人： CLARK PAN , ANDREAS M. KNORR , MICHAEL SCHAUER , CLAUDIA HIRTH-DIETRICH , SABINE KRAFT , BARBARA KREBS
发明人： CLARK PAN , ANDREAS M. KNORR , MICHAEL SCHAUER , CLAUDIA HIRTH-DIETRICH , SABINE KRAFT , BARBARA KREBS
IPC分类号： A61K39/395 , A61P9/00 , A61P1/16 , A61P35/00 , A61P11/00
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US07993849B2
公开(公告)日：2011-08-09
申请号：US12195286
申请日：2008-08-20
申请人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US20090017037A1
公开(公告)日：2009-01-15
申请号：US12195286
申请日：2008-08-20
申请人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US07091323B2
公开(公告)日：2006-08-15
申请号：US10128520
申请日：2002-04-24
申请人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
IPC分类号： A61K39/395 , C12P21/08 , C07K16/40
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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8.发明授权Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors 失效吡咯（2.1a）二氢异喹啉及其作为磷酸二酯酶10a抑制剂的用途公开(公告)号：US06930114B2
公开(公告)日：2005-08-16
申请号：US10451707
申请日：2001-12-04
申请人： Maria Theresia Niewöhner , Marcus Bauser , Jens-Kerim Ergüden , Dietmar Flubacher , Paul Naab , Thorsten-Oliver Repp , Jürgen Stoltefuss , Nils Burkhardt , Andrea Sewing , Michael Schauer , Karl-Heinz Schlemmer , Olaf Weber , Stephen J. Boyer , Mark Miglarese
发明人： Ulrich Niewöhner
IPC分类号： A61K31/4745 , A61P35/00 , A61P43/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer.
摘要翻译： 本发明涉及吡咯并[2.1-a]二氢异喹啉，它们是磷酸二酯酶10a的抑制剂，可用于抗癌。
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