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公开(公告)号：US20070160614A1
公开(公告)日：2007-07-12
申请号：US11504527
申请日：2006-08-14
申请人： Clark Pan , Andreas Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/40
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US07993849B2
公开(公告)日：2011-08-09
申请号：US12195286
申请日：2008-08-20
申请人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US20090017037A1
公开(公告)日：2009-01-15
申请号：US12195286
申请日：2008-08-20
申请人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US07091323B2
公开(公告)日：2006-08-15
申请号：US10128520
申请日：2002-04-24
申请人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
IPC分类号： A61K39/395 , C12P21/08 , C07K16/40
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US07432364B2
公开(公告)日：2008-10-07
申请号：US11504527
申请日：2006-08-14
申请人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas M. Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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公开(公告)号：US10189856B2
公开(公告)日：2019-01-29
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： A61K31/437 , A61K31/197 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D495/04 , C07D471/04 , A61K31/426 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D487/04
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
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7.发明申请Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc). 审中-公开使用sGC刺激剂，sGC激活剂，单独使用和与PDE5抑制剂的组合治疗系统性硬化症（SSc）。公开(公告)号：US20140038956A1
公开(公告)日：2014-02-06
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： C07D495/04 , C07C229/38 , C07D333/34 , C07D261/10 , C07D401/04 , C07D417/06 , C07D277/30 , C07D487/04 , A61K31/5377 , A61K31/506 , A61K31/197 , A61K31/4439 , A61K31/427 , A61K31/426 , A61K31/519 , A61K45/06 , C07D471/04
CPC分类号： C07D495/04 , A61K31/197 , A61K31/426 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
摘要翻译： 单独使用sGC刺激剂，sGC激活剂或与PDE5抑制剂联合用于预防和治疗纤维化疾病，如系统性硬化症，硬皮病和伴随的内脏纤维化。
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公开(公告)号：US07700653B2
公开(公告)日：2010-04-20
申请号：US11210131
申请日：2005-08-22
申请人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/195
CPC分类号： C07C229/38 , A61K31/197
摘要： This invention relates to methods for treating cardiovascular disorders selected from heart failure, thromboembolic disorders, venous diseases, and fibriotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) wherein the several variables are as defined in the specification and claims.
摘要翻译： 本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括施用有效量的式（I）化合物，其中若干变量如上所定义 在说明书和权利要求中。
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公开(公告)号：US20060111444A1
公开(公告)日：2006-05-25
申请号：US11210131
申请日：2005-08-22
申请人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/195
CPC分类号： C07C229/38 , A61K31/197
摘要： This invention relates to methods for treating cardiovascular disorders selected from heart failure, thromboembolic disorders, venous diseases, and fibriotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) wherein the several variables are as defined in the specification and claims.
摘要翻译： 本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括施用有效量的式（I）化合物，其中若干变量如上所定义 在说明书和权利要求中。
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公开(公告)号：US20050288366A1
公开(公告)日：2005-12-29
申请号：US11209517
申请日：2005-08-22
申请人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61P1/16 , A61K31/195 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/08 , A61P15/08 , A61P15/10 , A61P15/12 , A61P25/04 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P29/00 , A61P29/02 , A61P43/00 , C07B61/00 , C07C227/02 , C07C229/38 , C07C253/30 , C07C255/54 , A61K31/277
CPC分类号： C07C229/38 , C07C2601/14
摘要： This invention relates to methods for treating cardiovascular disorder selected from heart failure, thromboembolic disorders, venous diseases, and fibrotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) in which the several variables are as defined in the specification and claims.
摘要翻译： 本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括给予有效量的式（I）化合物，其中几个变量为 在说明书和权利要求中限定。
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